Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
Objective. Changes in the brain derived neurotrophic factor (BDNF) and glucocorticoid receptor (GR) expression in the prefrontal cortex (PFC) and hippocampus (HIP) are associated with psychiatric diseases and stress response. Chronic mild stress (CMS) may alter BDNF as well as GR levels in both the...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2021-07-01
|
| Series: | Endocrine Regulations |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/enr-2021-0016 |
| id |
doaj-0da3f6722b604d97a4296b06a4dd5406 |
|---|---|
| record_format |
Article |
| spelling |
doaj-0da3f6722b604d97a4296b06a4dd54062021-10-03T07:42:46ZengSciendoEndocrine Regulations1336-03292021-07-0155315316210.2478/enr-2021-0016Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stressOsacka Jana0Koprdova Romana1Tillinger Andrej2Pirnik Zdenko3Kiss Alexander4Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, SlovakiaInstitute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovak RepublicInstitute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, SlovakiaInstitute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, SlovakiaInstitute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, SlovakiaObjective. Changes in the brain derived neurotrophic factor (BDNF) and glucocorticoid receptor (GR) expression in the prefrontal cortex (PFC) and hippocampus (HIP) are associated with psychiatric diseases and stress response. Chronic mild stress (CMS) may alter BDNF as well as GR levels in both the PFC and the HIP. The aim of the present study was to find out whether chronic treatment with a typical antipsychotic haloperidol (HAL) and an atypical antipsychotic aripiprazole (ARI) may modify the CMS effect on the BDNF and GR expression in the above-mentioned structures.https://doi.org/10.2478/enr-2021-0016brain derived neurotrophic factorglucocorticoid receptorsc-fos-immunohisto-chemistryhaloperidolaripiprazoleprefrontal cortexhippocampusrat |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Osacka Jana Koprdova Romana Tillinger Andrej Pirnik Zdenko Kiss Alexander |
| spellingShingle |
Osacka Jana Koprdova Romana Tillinger Andrej Pirnik Zdenko Kiss Alexander Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress Endocrine Regulations brain derived neurotrophic factor glucocorticoid receptors c-fos-immunohisto-chemistry haloperidol aripiprazole prefrontal cortex hippocampus rat |
| author_facet |
Osacka Jana Koprdova Romana Tillinger Andrej Pirnik Zdenko Kiss Alexander |
| author_sort |
Osacka Jana |
| title |
Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress |
| title_short |
Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress |
| title_full |
Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress |
| title_fullStr |
Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress |
| title_full_unstemmed |
Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress |
| title_sort |
haloperidol and aripiprazole impact on the bdnf and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress |
| publisher |
Sciendo |
| series |
Endocrine Regulations |
| issn |
1336-0329 |
| publishDate |
2021-07-01 |
| description |
Objective. Changes in the brain derived neurotrophic factor (BDNF) and glucocorticoid receptor (GR) expression in the prefrontal cortex (PFC) and hippocampus (HIP) are associated with psychiatric diseases and stress response. Chronic mild stress (CMS) may alter BDNF as well as GR levels in both the PFC and the HIP. The aim of the present study was to find out whether chronic treatment with a typical antipsychotic haloperidol (HAL) and an atypical antipsychotic aripiprazole (ARI) may modify the CMS effect on the BDNF and GR expression in the above-mentioned structures. |
| topic |
brain derived neurotrophic factor glucocorticoid receptors c-fos-immunohisto-chemistry haloperidol aripiprazole prefrontal cortex hippocampus rat |
| url |
https://doi.org/10.2478/enr-2021-0016 |
| work_keys_str_mv |
AT osackajana haloperidolandaripiprazoleimpactonthebdnfandglucocorticoidreceptorlevelsintherathippocampusandprefrontalcortexeffectofthechronicmildstress AT koprdovaromana haloperidolandaripiprazoleimpactonthebdnfandglucocorticoidreceptorlevelsintherathippocampusandprefrontalcortexeffectofthechronicmildstress AT tillingerandrej haloperidolandaripiprazoleimpactonthebdnfandglucocorticoidreceptorlevelsintherathippocampusandprefrontalcortexeffectofthechronicmildstress AT pirnikzdenko haloperidolandaripiprazoleimpactonthebdnfandglucocorticoidreceptorlevelsintherathippocampusandprefrontalcortexeffectofthechronicmildstress AT kissalexander haloperidolandaripiprazoleimpactonthebdnfandglucocorticoidreceptorlevelsintherathippocampusandprefrontalcortexeffectofthechronicmildstress |
| _version_ |
1716845705649192960 |