SPECTROPHOTOMETRIC STUDIES OF SANGUINARINE-Β-CYCLODEXTRIN COMPLEX FORMATION

• Main Authors: Veaceslav Boldescu, Irina Kacso, Ioan Bratu, Gheorghe Duca
• Format: Article
• Language: English
• Published: Academy of Sciences of Moldova, Institute of Chemistry 2008-06-01
• Series: Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry
• Subjects: sanguinarine; β-cyclodextrin; inclusion complex; UV-vis spectrophotometry; association constant
• Online Access: http://www.cjm.asm.md/sites/default/files/article_files/Boldescu%20Spectrophotometric.pdf

The main aim of this study was to investigate the influence of pH and the presence of hydrophilic polymer polyvinylpyrrolidone on the formation of sanguinarine-β-cyclodextrin (SANG-β-CD) inclusion complex. Spectrophotometric studies of the SANG-β-CD systems in the presence and without 0.1 % PVP at the pH 5.0 did not show any evidence of the complex formation. However, the same systems showed several obvious evidences at the pH 8.0: the hyperchromic and the hypochromic effects and the presence of the isosbestic point in the region of 200 – 210 nm. The association constants calculated by three linear methods: Benesi-Hildebrand, Scott and Scatchard, were two times higher for the systems with addition of 0.1% PVP than for the systems without it.