Rapid assessment of myocardial infarct size in rodents using multi-slice inversion recovery late gadolinium enhancement CMR at 9.4T
<p>Abstract</p> <p>Background</p> <p>Myocardial infarction (MI) can be readily assessed using late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR). Inversion recovery (IR) sequences provide the highest contrast between enhanced infarct areas and hea...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2011-09-01
|
Series: | Journal of Cardiovascular Magnetic Resonance |
Online Access: | http://www.jcmr-online.com/content/13/1/44 |
id |
doaj-0db37dbc93d64c059f6d758fe2bfb42a |
---|---|
record_format |
Article |
spelling |
doaj-0db37dbc93d64c059f6d758fe2bfb42a2020-11-25T00:09:56ZengBMCJournal of Cardiovascular Magnetic Resonance1097-66471532-429X2011-09-011314410.1186/1532-429X-13-44Rapid assessment of myocardial infarct size in rodents using multi-slice inversion recovery late gadolinium enhancement CMR at 9.4THausenloy Derek JYellon Derek MLim Shiang YCheung King KPrice Anthony NLythgoe Mark F<p>Abstract</p> <p>Background</p> <p>Myocardial infarction (MI) can be readily assessed using late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR). Inversion recovery (IR) sequences provide the highest contrast between enhanced infarct areas and healthy myocardium. Applying such methods to small animals is challenging due to rapid respiratory and cardiac rates relative to <it>T</it><sub>1 </sub>relaxation.</p> <p>Methods</p> <p>Here we present a fast and robust protocol for assessing LGE in small animals using a multi-slice IR gradient echo sequence for efficient assessment of LGE. An additional Look-Locker sequence was used to assess the optimum inversion point on an individual basis and to determine most appropriate gating points for both rat and mouse. The technique was applied to two preclinical scenarios: i) an acute (2 hour) reperfused model of MI in rats and ii) mice 2 days following non-reperfused MI.</p> <p>Results</p> <p>LGE images from all animals revealed clear areas of enhancement allowing for easy volume segmentation. Typical inversion times required to null healthy myocardium in rats were between 300-450 ms equivalent to 2-3 R-waves and ~330 ms in mice, typically 3 R-waves following inversion. Data from rats was also validated against triphenyltetrazolium chloride staining and revealed close agreement for infarct size.</p> <p>Conclusion</p> <p>The LGE protocol presented provides a reliable method for acquiring images of high contrast and quality without excessive scan times, enabling higher throughput in experimental studies requiring reliable assessment of MI.</p> http://www.jcmr-online.com/content/13/1/44 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hausenloy Derek J Yellon Derek M Lim Shiang Y Cheung King K Price Anthony N Lythgoe Mark F |
spellingShingle |
Hausenloy Derek J Yellon Derek M Lim Shiang Y Cheung King K Price Anthony N Lythgoe Mark F Rapid assessment of myocardial infarct size in rodents using multi-slice inversion recovery late gadolinium enhancement CMR at 9.4T Journal of Cardiovascular Magnetic Resonance |
author_facet |
Hausenloy Derek J Yellon Derek M Lim Shiang Y Cheung King K Price Anthony N Lythgoe Mark F |
author_sort |
Hausenloy Derek J |
title |
Rapid assessment of myocardial infarct size in rodents using multi-slice inversion recovery late gadolinium enhancement CMR at 9.4T |
title_short |
Rapid assessment of myocardial infarct size in rodents using multi-slice inversion recovery late gadolinium enhancement CMR at 9.4T |
title_full |
Rapid assessment of myocardial infarct size in rodents using multi-slice inversion recovery late gadolinium enhancement CMR at 9.4T |
title_fullStr |
Rapid assessment of myocardial infarct size in rodents using multi-slice inversion recovery late gadolinium enhancement CMR at 9.4T |
title_full_unstemmed |
Rapid assessment of myocardial infarct size in rodents using multi-slice inversion recovery late gadolinium enhancement CMR at 9.4T |
title_sort |
rapid assessment of myocardial infarct size in rodents using multi-slice inversion recovery late gadolinium enhancement cmr at 9.4t |
publisher |
BMC |
series |
Journal of Cardiovascular Magnetic Resonance |
issn |
1097-6647 1532-429X |
publishDate |
2011-09-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Myocardial infarction (MI) can be readily assessed using late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR). Inversion recovery (IR) sequences provide the highest contrast between enhanced infarct areas and healthy myocardium. Applying such methods to small animals is challenging due to rapid respiratory and cardiac rates relative to <it>T</it><sub>1 </sub>relaxation.</p> <p>Methods</p> <p>Here we present a fast and robust protocol for assessing LGE in small animals using a multi-slice IR gradient echo sequence for efficient assessment of LGE. An additional Look-Locker sequence was used to assess the optimum inversion point on an individual basis and to determine most appropriate gating points for both rat and mouse. The technique was applied to two preclinical scenarios: i) an acute (2 hour) reperfused model of MI in rats and ii) mice 2 days following non-reperfused MI.</p> <p>Results</p> <p>LGE images from all animals revealed clear areas of enhancement allowing for easy volume segmentation. Typical inversion times required to null healthy myocardium in rats were between 300-450 ms equivalent to 2-3 R-waves and ~330 ms in mice, typically 3 R-waves following inversion. Data from rats was also validated against triphenyltetrazolium chloride staining and revealed close agreement for infarct size.</p> <p>Conclusion</p> <p>The LGE protocol presented provides a reliable method for acquiring images of high contrast and quality without excessive scan times, enabling higher throughput in experimental studies requiring reliable assessment of MI.</p> |
url |
http://www.jcmr-online.com/content/13/1/44 |
work_keys_str_mv |
AT hausenloyderekj rapidassessmentofmyocardialinfarctsizeinrodentsusingmultisliceinversionrecoverylategadoliniumenhancementcmrat94t AT yellonderekm rapidassessmentofmyocardialinfarctsizeinrodentsusingmultisliceinversionrecoverylategadoliniumenhancementcmrat94t AT limshiangy rapidassessmentofmyocardialinfarctsizeinrodentsusingmultisliceinversionrecoverylategadoliniumenhancementcmrat94t AT cheungkingk rapidassessmentofmyocardialinfarctsizeinrodentsusingmultisliceinversionrecoverylategadoliniumenhancementcmrat94t AT priceanthonyn rapidassessmentofmyocardialinfarctsizeinrodentsusingmultisliceinversionrecoverylategadoliniumenhancementcmrat94t AT lythgoemarkf rapidassessmentofmyocardialinfarctsizeinrodentsusingmultisliceinversionrecoverylategadoliniumenhancementcmrat94t |
_version_ |
1725409922817982464 |