Assessing Pemphigus Recurrence Rate using the Analysis of the Gap Times between Recurrent Events
Background and Objectives : The aim of this study was to assess the disease trajectory and recurrence rate of pemphigus based on the analysis of the gap time between successive recurrent events. In this regard, the most important associated factors with the risk of recurrence could be explained. ...
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Tehran University of Medical Sciences
2014-06-01
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doaj-0db3bf977a6b47b78ec2af8de61fabb92021-09-02T17:54:38ZfasTehran University of Medical Sciencesمجله اپیدمیولوژی ایران1735-74892228-75072014-06-0110118Assessing Pemphigus Recurrence Rate using the Analysis of the Gap Times between Recurrent EventsA Saki Malehi 0E Hajizadeh1K Ahmadi2P Mansouri3 Department of Biostatistics,Faculty of Medical Sciences, TarbiatModares University, Tehran, Iran Department of Biostatistics,Faculty of Medical Sciences, TarbiatModares University, Tehran, Iran Department of Biostatistics,Health Faculty , Jundishapur University of Medical Sciences, Ahvaz, Iran Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran Background and Objectives : The aim of this study was to assess the disease trajectory and recurrence rate of pemphigus based on the analysis of the gap time between successive recurrent events. In this regard, the most important associated factors with the risk of recurrence could be explained. Methods: This longitudinal study was performed on 112 pemphigus patients who attended the dermatology department of Imam Khomeini Hospital, Tehran, Iran, from March 2006 to January 2013. The study duration was considered from the diagnosis of the disease to December 2013. Recurrent events were analyzed based on the gap time between successive events using the multivariate time dependent frailty model. The time between two recurrent gap times was determined monthly between two successive events. Results : Decreasing the gap times between two successive events indicates that the subsequent event after the first recurrence occurs with shorter time intervals. So, the disease trajectory represents an increase in the recurrence rate over time. Based on the results of multivariate frailty model, IgG antibody's level was the only effective factor on the recurrence hazard rate of the patients. Also, this model proved that the frailty effects were time dependent frailties. Conclusion: Assessing the disease trajectory and recurrence hazard rate can be achieved through analyzing the gap time between successive recurrent events. This analysis also identifies the factors that influence the risk of subsequent recurrent events. http://irje.tums.ac.ir/browse.php?a_code=A-10-25-5058&slc_lang=en&sid=1Analysis of recurrent events Gap times Time dependent frailty models Pemphigus |
collection |
DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
A Saki Malehi E Hajizadeh K Ahmadi P Mansouri |
spellingShingle |
A Saki Malehi E Hajizadeh K Ahmadi P Mansouri Assessing Pemphigus Recurrence Rate using the Analysis of the Gap Times between Recurrent Events مجله اپیدمیولوژی ایران Analysis of recurrent events Gap times Time dependent frailty models Pemphigus |
author_facet |
A Saki Malehi E Hajizadeh K Ahmadi P Mansouri |
author_sort |
A Saki Malehi |
title |
Assessing Pemphigus Recurrence Rate using the Analysis of the Gap Times between Recurrent Events |
title_short |
Assessing Pemphigus Recurrence Rate using the Analysis of the Gap Times between Recurrent Events |
title_full |
Assessing Pemphigus Recurrence Rate using the Analysis of the Gap Times between Recurrent Events |
title_fullStr |
Assessing Pemphigus Recurrence Rate using the Analysis of the Gap Times between Recurrent Events |
title_full_unstemmed |
Assessing Pemphigus Recurrence Rate using the Analysis of the Gap Times between Recurrent Events |
title_sort |
assessing pemphigus recurrence rate using the analysis of the gap times between recurrent events |
publisher |
Tehran University of Medical Sciences |
series |
مجله اپیدمیولوژی ایران |
issn |
1735-7489 2228-7507 |
publishDate |
2014-06-01 |
description |
Background and Objectives : The aim of this study was to assess the disease trajectory and recurrence rate of pemphigus based on the analysis of the gap time between successive recurrent events. In this regard, the most important associated factors with the risk of recurrence could be explained. Methods: This longitudinal study was performed on 112 pemphigus patients who attended the dermatology department of Imam Khomeini Hospital, Tehran, Iran, from March 2006 to January 2013. The study duration was considered from the diagnosis of the disease to December 2013. Recurrent events were analyzed based on the gap time between successive events using the multivariate time dependent frailty model. The time between two recurrent gap times was determined monthly between two successive events. Results : Decreasing the gap times between two successive events indicates that the subsequent event after the first recurrence occurs with shorter time intervals. So, the disease trajectory represents an increase in the recurrence rate over time. Based on the results of multivariate frailty model, IgG antibody's level was the only effective factor on the recurrence hazard rate of the patients. Also, this model proved that the frailty effects were time dependent frailties. Conclusion: Assessing the disease trajectory and recurrence hazard rate can be achieved through analyzing the gap time between successive recurrent events. This analysis also identifies the factors that influence the risk of subsequent recurrent events. |
topic |
Analysis of recurrent events Gap times Time dependent frailty models Pemphigus |
url |
http://irje.tums.ac.ir/browse.php?a_code=A-10-25-5058&slc_lang=en&sid=1 |
work_keys_str_mv |
AT asakimalehi assessingpemphigusrecurrencerateusingtheanalysisofthegaptimesbetweenrecurrentevents AT ehajizadeh assessingpemphigusrecurrencerateusingtheanalysisofthegaptimesbetweenrecurrentevents AT kahmadi assessingpemphigusrecurrencerateusingtheanalysisofthegaptimesbetweenrecurrentevents AT pmansouri assessingpemphigusrecurrencerateusingtheanalysisofthegaptimesbetweenrecurrentevents |
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