From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol
In spite of the global reputation of ethanol as the psychopharmacologically active ingredient of alcoholic drinks, the neurobiological basis of the central effects of ethanol still presents some dark sides due to a number of unanswered questions related to both its precise mechanism of action and it...
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doaj-0db4af7b44be4f0f9e01acc6aaa049332020-11-25T03:32:03ZengSAGE PublishingJournal of Experimental Neuroscience1179-06952016-01-011010.4137/JEN.S25099From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of EthanolAlessandra T. Peana0Michela Rosas1Simona Porru2Elio Acquas3 Department of Chemistry and Pharmacy, University of Sassari, Sassari, Italy. Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy. Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy. Centre of Excellence on Neurobiology of Addiction, University of Cagliari, Cagliari, Italy.In spite of the global reputation of ethanol as the psychopharmacologically active ingredient of alcoholic drinks, the neurobiological basis of the central effects of ethanol still presents some dark sides due to a number of unanswered questions related to both its precise mechanism of action and its metabolism. Accordingly, ethanol represents the interesting example of a compound whose actions cannot be explained as simply due to the involvement of a single receptor/neurotransmitter, a scenario further complicated by the robust evidence that two main metabolites, acetaldehyde and salsolinol, exert many effects similar to those of their parent compound. The present review recapitulates, in a perspective manner, the major and most recent advances that in the last decades boosted a significant growth in the understanding on the role of ethanol metabolism, in particular, in the neurobiological basis of its central effects.https://doi.org/10.4137/JEN.S25099 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alessandra T. Peana Michela Rosas Simona Porru Elio Acquas |
spellingShingle |
Alessandra T. Peana Michela Rosas Simona Porru Elio Acquas From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol Journal of Experimental Neuroscience |
author_facet |
Alessandra T. Peana Michela Rosas Simona Porru Elio Acquas |
author_sort |
Alessandra T. Peana |
title |
From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol |
title_short |
From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol |
title_full |
From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol |
title_fullStr |
From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol |
title_full_unstemmed |
From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol |
title_sort |
from ethanol to salsolinol: role of ethanol metabolites in the effects of ethanol |
publisher |
SAGE Publishing |
series |
Journal of Experimental Neuroscience |
issn |
1179-0695 |
publishDate |
2016-01-01 |
description |
In spite of the global reputation of ethanol as the psychopharmacologically active ingredient of alcoholic drinks, the neurobiological basis of the central effects of ethanol still presents some dark sides due to a number of unanswered questions related to both its precise mechanism of action and its metabolism. Accordingly, ethanol represents the interesting example of a compound whose actions cannot be explained as simply due to the involvement of a single receptor/neurotransmitter, a scenario further complicated by the robust evidence that two main metabolites, acetaldehyde and salsolinol, exert many effects similar to those of their parent compound. The present review recapitulates, in a perspective manner, the major and most recent advances that in the last decades boosted a significant growth in the understanding on the role of ethanol metabolism, in particular, in the neurobiological basis of its central effects. |
url |
https://doi.org/10.4137/JEN.S25099 |
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1724570060661456896 |