Salinomycin induces autophagy in colon and breast cancer cells with concomitant generation of reactive oxygen species.

Salinomycin induces autophagy in colon and breast cancer cells with concomitant generation of reactive oxygen species.

BACKGROUND: Salinomycin is a polyether ionophore antibiotic that has recently been shown to induce cell death in human cancer cells displaying multiple mechanisms of drug resistance. The underlying mechanisms leading to cell death after salinomycin treatment have not been well characterized. We ther...

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Bibliographic Details
Main Authors: Berlinda Verdoodt, Markus Vogt, Inge Schmitz, Sven-Thorsten Liffers, Andrea Tannapfel, Alireza Mirmohammadsadegh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3446972?pdf=render

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