Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man’s Trash Is Another Man’s Treasure

Urinary bladder cancer (UBC) is the most common malignancy of the urinary tract in humans, with an estimated global prevalence of 1.1 million cases over 5 years. Because of its high rates of recurrence and resistance to chemotherapy, UBC is one of the most expensive cancers to treat, resulting in si...

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Main Authors:	Sarah Minkler, Fabrice Lucien, Michael J. Kimber, Dipak K. Sahoo, Agnes Bourgois-Mochel, Margaret Musser, Chad Johannes, Igor Frank, John Cheville, Karin Allenspach, Jonathan P. Mochel
Format:	Article
Language:	English
Published:	MDPI AG 2021-01-01
Series:	Cancers
Subjects:	bladder cancer organoids exosomes precision medicine one health
Online Access:	https://www.mdpi.com/2072-6694/13/3/422

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spelling	doaj-0dda59f830d840f6aebd71e90b828fe92021-01-24T00:01:16ZengMDPI AGCancers2072-66942021-01-011342242210.3390/cancers13030422Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man’s Trash Is Another Man’s TreasureSarah Minkler0Fabrice Lucien1Michael J. Kimber2Dipak K. Sahoo3Agnes Bourgois-Mochel4Margaret Musser5Chad Johannes6Igor Frank7John Cheville8Karin Allenspach9Jonathan P. Mochel10SMART Translational Medicine, Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250, USADepartment of Urology, Mayo Clinic, Rochester, MN 55902, USADepartment of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250, USASMART Translational Medicine, Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250, USADepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250, USADepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250, USADepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250, USADepartment of Urology, Mayo Clinic, Rochester, MN 55902, USADepartment of Urology, Mayo Clinic, Rochester, MN 55902, USASMART Translational Medicine, Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250, USASMART Translational Medicine, Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250, USAUrinary bladder cancer (UBC) is the most common malignancy of the urinary tract in humans, with an estimated global prevalence of 1.1 million cases over 5 years. Because of its high rates of recurrence and resistance to chemotherapy, UBC is one of the most expensive cancers to treat, resulting in significant health care costs. The development of innovative molecular and cellular tools is necessary to refine patient stratification and help predict response to treatment. Urine is an underused resource of biological components shed from bladder tumors, such as exfoliated cells and extracellular vesicles, that could serve as molecular fingerprints and provide valuable biological insights into tumor phenotype and mechanisms of resistance to chemotherapy. Additionally, characterization of urine-derived extracellular vesicles and cells could be used as reliable biomarkers for prediction of response to neoadjuvant therapy.https://www.mdpi.com/2072-6694/13/3/422bladder cancerorganoidsexosomesprecision medicineone health
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sarah Minkler Fabrice Lucien Michael J. Kimber Dipak K. Sahoo Agnes Bourgois-Mochel Margaret Musser Chad Johannes Igor Frank John Cheville Karin Allenspach Jonathan P. Mochel
spellingShingle	Sarah Minkler Fabrice Lucien Michael J. Kimber Dipak K. Sahoo Agnes Bourgois-Mochel Margaret Musser Chad Johannes Igor Frank John Cheville Karin Allenspach Jonathan P. Mochel Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man’s Trash Is Another Man’s Treasure Cancers bladder cancer organoids exosomes precision medicine one health
author_facet	Sarah Minkler Fabrice Lucien Michael J. Kimber Dipak K. Sahoo Agnes Bourgois-Mochel Margaret Musser Chad Johannes Igor Frank John Cheville Karin Allenspach Jonathan P. Mochel
author_sort	Sarah Minkler
title	Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man’s Trash Is Another Man’s Treasure
title_short	Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man’s Trash Is Another Man’s Treasure
title_full	Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man’s Trash Is Another Man’s Treasure
title_fullStr	Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man’s Trash Is Another Man’s Treasure
title_full_unstemmed	Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man’s Trash Is Another Man’s Treasure
title_sort	emerging roles of urine-derived components for the management of bladder cancer: one man’s trash is another man’s treasure
publisher	MDPI AG
series	Cancers
issn	2072-6694
publishDate	2021-01-01
description	Urinary bladder cancer (UBC) is the most common malignancy of the urinary tract in humans, with an estimated global prevalence of 1.1 million cases over 5 years. Because of its high rates of recurrence and resistance to chemotherapy, UBC is one of the most expensive cancers to treat, resulting in significant health care costs. The development of innovative molecular and cellular tools is necessary to refine patient stratification and help predict response to treatment. Urine is an underused resource of biological components shed from bladder tumors, such as exfoliated cells and extracellular vesicles, that could serve as molecular fingerprints and provide valuable biological insights into tumor phenotype and mechanisms of resistance to chemotherapy. Additionally, characterization of urine-derived extracellular vesicles and cells could be used as reliable biomarkers for prediction of response to neoadjuvant therapy.
topic	bladder cancer organoids exosomes precision medicine one health
url	https://www.mdpi.com/2072-6694/13/3/422
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Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man’s Trash Is Another Man’s Treasure

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