Comparing effects of metformin and ginger rhizome extract on the pituitary - gonad function in adult female rats with polycystic ovary syndrome

• Main Authors: Mahbobeh Foroozandeh, Ebrahim Hosseini
• Format: Article
• Language: fas
• Published: Yasuj University Of Medical Sciences 2017-06-01
• Series: Armaghane Danesh Bimonthly Journal
• Subjects: Keyword: polycystic ovary; metformin; ginger rhizome; progesterone; testosterone; estrogen; FSH; LH; Rat
• Online Access: http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-724-6&slc_lang=en&sid=1
• ISSN: 1728-6514; 1728-6506

Background & aim: Polycystic Ovary Syndrome (PCOS) is one of the most common causes of infertility in women. Due to the prevalence of PCOS in worldwide, this study aimed to compare the effect of metformin with ginger on pituitary-gonad function in PCOS adult female rats was performed. Methods: In this experimental study, 72 adult female rats divided to control, sham PCOS and 7 experimental groups PCOS receiving metformin at 500mg/kg, the ginger at doses 100, 200 & 300mg/kg and ginger at doses 100, 200 & 300mg /kg with metformin at 500 mg/kg were used. All injections by gavage and for 28 days were conducted. After phlebotomizing the animals, to measure hormones FSH, LH and estrogen, progesterone and testosterone, their ovaries removed and after preparing tissue sections, follicles were counted. Data obtained by 18-SPSS software and ANOVA and Duncan were analyzed, then the significant difference of data at P> 0.05was considered. Results: The results showed that letrozole by creating PCOS causes to increase atretic follicles, testosterone, estrogen and reduce other follicles and FSH at P<0.01, and metformin and Ginger alone and together cause to reduce atretic follicles, testosterone, estrogen and increase other follicles and FSH at P<0.01. Conclusion: The results showed that metformin and Ginger alone or together cause to improve PCOS, and these improvements in both groups receiving simultaneous ginger with metformin can be seen more.