Square-Wave Voltammetric Determination of Antihistaminic Drug Hydroxyzine in Pharmaceuticals Using a Boron-doped Diamond Electrode

• Main Authors: Jessica Scremin, Elen Romão Sartori
• Format: Article
• Language: English
• Published: Universidade Federal de Mato Grosso do Sul 2016-07-01
• Series: Orbital: The Electronic Journal of Chemistry
• Subjects: hydroxyzine determination; boron-doped diamond electrode; cathodic pretreatment; antihistaminic drug; pharmaceutical formulations
• Online Access: http://orbital.ufms.br/index.php/Chemistry/article/view/833

<p class="orbitalabstract"><span lang="EN-GB">The determination of </span><span lang="EN-US">antihistaminic</span><span lang="EN-GB"> hydroxyzine using square-wave voltammetry and a cathodically pretreated boron-doped diamond electrode is described. The obtained analytical curve was linear in the hydroxyzine concentration range 0.50 – 20.0 </span><span lang="EN-GB">m</span><span lang="EN-GB">mol L</span>^{<span lang="EN-US">–</span>}^{<span lang="EN-GB">1</span>}<span lang="EN-GB"> </span><span lang="EN-US">in 0.1 mol L^–1 HCl solution</span><span lang="EN-GB">, with a detection limit of 0.43 </span><span lang="EN-GB">m</span><span lang="EN-GB">mol L</span>^{<span lang="EN-US">–</span>}^{<span lang="EN-GB">1</span>}<span lang="EN-GB">. Addition and recovery studies in commercial tables and liquid formulations showed excellent recovery values ranging from </span><span lang="EN-US">94.3 % to 104 %</span><span lang="EN-GB">. Furthermore, t</span><span lang="EN-US">he proposed method was successfully applied in the determination of hydroxyzine in several pharmaceutical formulations and the results were in a close agreement at a 95 % confidence level with those obtained using an official potentiometric method</span><span lang="EN-GB">.</span></p><p class="orbitalabstract"> </p><p class="orbitalabstract"><span lang="EN-GB">DOI: <a href="http://dx.doi.org/10.17807/orbital.v8i3.833">http://dx.doi.org/10.17807/orbital.v8i3.833</a><br /></span></p>