Square-Wave Voltammetric Determination of Antihistaminic Drug Hydroxyzine in Pharmaceuticals Using a Boron-doped Diamond Electrode
<p class="orbitalabstract"><span lang="EN-GB">The determination of </span><span lang="EN-US">antihistaminic</span><span lang="EN-GB"> hydroxyzine using square-wave voltammetry and a cathodically pretreated boron-doped diamon...
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Universidade Federal de Mato Grosso do Sul
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doaj-0de101cc5f03400bb68a684f9cb62fef2021-07-07T19:22:37ZengUniversidade Federal de Mato Grosso do SulOrbital: The Electronic Journal of Chemistry1984-64282016-07-018317418010.17807/orbital.v8i3.833380Square-Wave Voltammetric Determination of Antihistaminic Drug Hydroxyzine in Pharmaceuticals Using a Boron-doped Diamond ElectrodeJessica Scremin0Elen Romão Sartori1Universidade Estadual de LondrinaUniversidade Estadual de Londrina<p class="orbitalabstract"><span lang="EN-GB">The determination of </span><span lang="EN-US">antihistaminic</span><span lang="EN-GB"> hydroxyzine using square-wave voltammetry and a cathodically pretreated boron-doped diamond electrode is described. The obtained analytical curve was linear in the hydroxyzine concentration range 0.50 – 20.0 </span><span lang="EN-GB">m</span><span lang="EN-GB">mol L</span><sup><span lang="EN-US">–</span></sup><sup><span lang="EN-GB">1</span></sup><span lang="EN-GB"> </span><span lang="EN-US">in 0.1 mol L<sup>–1</sup> HCl solution</span><span lang="EN-GB">, with a detection limit of 0.43 </span><span lang="EN-GB">m</span><span lang="EN-GB">mol L</span><sup><span lang="EN-US">–</span></sup><sup><span lang="EN-GB">1</span></sup><span lang="EN-GB">. Addition and recovery studies in commercial tables and liquid formulations showed excellent recovery values ranging from </span><span lang="EN-US">94.3 % to 104 %</span><span lang="EN-GB">. Furthermore, t</span><span lang="EN-US">he proposed method was successfully applied in the determination of hydroxyzine in several pharmaceutical formulations and the results were in a close agreement at a 95 % confidence level with those obtained using an official potentiometric method</span><span lang="EN-GB">.</span></p><p class="orbitalabstract"> </p><p class="orbitalabstract"><span lang="EN-GB">DOI: <a href="http://dx.doi.org/10.17807/orbital.v8i3.833">http://dx.doi.org/10.17807/orbital.v8i3.833</a><br /></span></p>http://orbital.ufms.br/index.php/Chemistry/article/view/833hydroxyzine determinationboron-doped diamond electrodecathodic pretreatmentantihistaminic drugpharmaceutical formulations |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jessica Scremin Elen Romão Sartori |
spellingShingle |
Jessica Scremin Elen Romão Sartori Square-Wave Voltammetric Determination of Antihistaminic Drug Hydroxyzine in Pharmaceuticals Using a Boron-doped Diamond Electrode Orbital: The Electronic Journal of Chemistry hydroxyzine determination boron-doped diamond electrode cathodic pretreatment antihistaminic drug pharmaceutical formulations |
author_facet |
Jessica Scremin Elen Romão Sartori |
author_sort |
Jessica Scremin |
title |
Square-Wave Voltammetric Determination of Antihistaminic Drug Hydroxyzine in Pharmaceuticals Using a Boron-doped Diamond Electrode |
title_short |
Square-Wave Voltammetric Determination of Antihistaminic Drug Hydroxyzine in Pharmaceuticals Using a Boron-doped Diamond Electrode |
title_full |
Square-Wave Voltammetric Determination of Antihistaminic Drug Hydroxyzine in Pharmaceuticals Using a Boron-doped Diamond Electrode |
title_fullStr |
Square-Wave Voltammetric Determination of Antihistaminic Drug Hydroxyzine in Pharmaceuticals Using a Boron-doped Diamond Electrode |
title_full_unstemmed |
Square-Wave Voltammetric Determination of Antihistaminic Drug Hydroxyzine in Pharmaceuticals Using a Boron-doped Diamond Electrode |
title_sort |
square-wave voltammetric determination of antihistaminic drug hydroxyzine in pharmaceuticals using a boron-doped diamond electrode |
publisher |
Universidade Federal de Mato Grosso do Sul |
series |
Orbital: The Electronic Journal of Chemistry |
issn |
1984-6428 |
publishDate |
2016-07-01 |
description |
<p class="orbitalabstract"><span lang="EN-GB">The determination of </span><span lang="EN-US">antihistaminic</span><span lang="EN-GB"> hydroxyzine using square-wave voltammetry and a cathodically pretreated boron-doped diamond electrode is described. The obtained analytical curve was linear in the hydroxyzine concentration range 0.50 – 20.0 </span><span lang="EN-GB">m</span><span lang="EN-GB">mol L</span><sup><span lang="EN-US">–</span></sup><sup><span lang="EN-GB">1</span></sup><span lang="EN-GB"> </span><span lang="EN-US">in 0.1 mol L<sup>–1</sup> HCl solution</span><span lang="EN-GB">, with a detection limit of 0.43 </span><span lang="EN-GB">m</span><span lang="EN-GB">mol L</span><sup><span lang="EN-US">–</span></sup><sup><span lang="EN-GB">1</span></sup><span lang="EN-GB">. Addition and recovery studies in commercial tables and liquid formulations showed excellent recovery values ranging from </span><span lang="EN-US">94.3 % to 104 %</span><span lang="EN-GB">. Furthermore, t</span><span lang="EN-US">he proposed method was successfully applied in the determination of hydroxyzine in several pharmaceutical formulations and the results were in a close agreement at a 95 % confidence level with those obtained using an official potentiometric method</span><span lang="EN-GB">.</span></p><p class="orbitalabstract"> </p><p class="orbitalabstract"><span lang="EN-GB">DOI: <a href="http://dx.doi.org/10.17807/orbital.v8i3.833">http://dx.doi.org/10.17807/orbital.v8i3.833</a><br /></span></p> |
topic |
hydroxyzine determination boron-doped diamond electrode cathodic pretreatment antihistaminic drug pharmaceutical formulations |
url |
http://orbital.ufms.br/index.php/Chemistry/article/view/833 |
work_keys_str_mv |
AT jessicascremin squarewavevoltammetricdeterminationofantihistaminicdrughydroxyzineinpharmaceuticalsusingaborondopeddiamondelectrode AT elenromaosartori squarewavevoltammetricdeterminationofantihistaminicdrughydroxyzineinpharmaceuticalsusingaborondopeddiamondelectrode |
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