Human embryonic stem cells: preclinical perspectives
<p>Abstract</p> <p>Human embryonic stem cells (hESCs) have been extensively discussed in public and scientific communities for their potential in treating diseases and injuries. However, not much has been achieved in turning them into safe therapeutic agents. The hurdles in transfo...
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doaj-0de31ccb469a4643b918c3a5311d3d552020-11-25T00:13:43ZengBMCJournal of Translational Medicine1479-58762008-01-0161710.1186/1479-5876-6-7Human embryonic stem cells: preclinical perspectivesSarda KanchanDeb Kaushik<p>Abstract</p> <p>Human embryonic stem cells (hESCs) have been extensively discussed in public and scientific communities for their potential in treating diseases and injuries. However, not much has been achieved in turning them into safe therapeutic agents. The hurdles in transforming hESCs to therapies start right with the way these cells are derived and maintained in the laboratory, and goes up-to clinical complications related to need for patient specific cell lines, gender specific aspects, age of the cells, and several post transplantation uncertainties. The different types of cells derived through directed differentiation of hESC and used successfully in animal disease and injury models are described briefly. This review gives a brief outlook on the present and the future of hESC based therapies, and talks about the technological advances required for a safe transition from laboratory to clinic.</p> http://www.translational-medicine.com/content/6/1/7 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sarda Kanchan Deb Kaushik |
spellingShingle |
Sarda Kanchan Deb Kaushik Human embryonic stem cells: preclinical perspectives Journal of Translational Medicine |
author_facet |
Sarda Kanchan Deb Kaushik |
author_sort |
Sarda Kanchan |
title |
Human embryonic stem cells: preclinical perspectives |
title_short |
Human embryonic stem cells: preclinical perspectives |
title_full |
Human embryonic stem cells: preclinical perspectives |
title_fullStr |
Human embryonic stem cells: preclinical perspectives |
title_full_unstemmed |
Human embryonic stem cells: preclinical perspectives |
title_sort |
human embryonic stem cells: preclinical perspectives |
publisher |
BMC |
series |
Journal of Translational Medicine |
issn |
1479-5876 |
publishDate |
2008-01-01 |
description |
<p>Abstract</p> <p>Human embryonic stem cells (hESCs) have been extensively discussed in public and scientific communities for their potential in treating diseases and injuries. However, not much has been achieved in turning them into safe therapeutic agents. The hurdles in transforming hESCs to therapies start right with the way these cells are derived and maintained in the laboratory, and goes up-to clinical complications related to need for patient specific cell lines, gender specific aspects, age of the cells, and several post transplantation uncertainties. The different types of cells derived through directed differentiation of hESC and used successfully in animal disease and injury models are described briefly. This review gives a brief outlook on the present and the future of hESC based therapies, and talks about the technological advances required for a safe transition from laboratory to clinic.</p> |
url |
http://www.translational-medicine.com/content/6/1/7 |
work_keys_str_mv |
AT sardakanchan humanembryonicstemcellspreclinicalperspectives AT debkaushik humanembryonicstemcellspreclinicalperspectives |
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