Epidemiological and clinical differences of coronavirus disease 2019 patients with distinct viral exposure history
Since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread from the early epicenter, Wuhan, to the rest of China, the virulence of SARS-CoV-2 might have evolved at different phases of the pandemic. We therefore compared the unique features among 62 coronavirus disease 2019 (COVID-19)...
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doaj-0dea6c10186f428eb2dce132e79338202021-01-15T14:09:07ZengTaylor & Francis GroupVirulence2150-55942150-56082020-01-011111015102310.1080/21505594.2020.18028701802870Epidemiological and clinical differences of coronavirus disease 2019 patients with distinct viral exposure historyYinjie Gao0Xuemei Ma1Jingfeng Bi2Jindong Chu3Bo Liu4Chunsheng Chi5Jianguo Yan6Xiaoli Yu7Fangming Liu8Xiaohong Deng9Hongbing Zhang10Bo Jin11Research Centre for Clinical and Translational Medicine, the Fifth Medical Center, Chinese PLA General Hospital and National Clinical Research Center for Infectious DiseasesResearch Centre for Clinical and Translational Medicine, the Fifth Medical Center, Chinese PLA General Hospital and National Clinical Research Center for Infectious DiseasesResearch Centre for Clinical and Translational Medicine, the Fifth Medical Center, Chinese PLA General Hospital and National Clinical Research Center for Infectious DiseasesResearch Centre for Clinical and Translational Medicine, the Fifth Medical Center, Chinese PLA General Hospital and National Clinical Research Center for Infectious DiseasesResearch Centre for Clinical and Translational Medicine, the Fifth Medical Center, Chinese PLA General Hospital and National Clinical Research Center for Infectious DiseasesResearch Centre for Clinical and Translational Medicine, the Fifth Medical Center, Chinese PLA General Hospital and National Clinical Research Center for Infectious DiseasesResearch Centre for Clinical and Translational Medicine, the Fifth Medical Center, Chinese PLA General Hospital and National Clinical Research Center for Infectious DiseasesResearch Centre for Clinical and Translational Medicine, the Fifth Medical Center, Chinese PLA General Hospital and National Clinical Research Center for Infectious DiseasesInstitute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing MenlobiotechInstitute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical CollegeResearch Centre for Clinical and Translational Medicine, the Fifth Medical Center, Chinese PLA General Hospital and National Clinical Research Center for Infectious DiseasesSince severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread from the early epicenter, Wuhan, to the rest of China, the virulence of SARS-CoV-2 might have evolved at different phases of the pandemic. We therefore compared the unique features among 62 coronavirus disease 2019 (COVID-19) inpatients who contracted SARS-CoV-2 in Wuhan (15 cases), exposed to the patients from Wuhan (26 cases), or acquired the disease without exposure to Wuhan patients (21 cases). Median incubation periods are 4.5 days (3–5) for Wuhan patients, 8 days (3–11) for those infected by Wuhan patients, and 12 days (7–13) for those without aforementioned experience. The disease onset dates are earliest for Wuhan patients and latest for those without exposure to Wuhan patients. Blood lymphocytes were lowest in Wuhan patients, lower in those affected by Wuhan patients, and modest reduced in remaining ones. Disease severity is worst for Wuhan patients, and modest for those without contact with Wuhan patients. Wuhan patients had longest (27 days, 18–28), those transmitted by Wuhan patients had intermediate (16 days, 8–23), and the rest of the patients had shortest (13 days, 8.5–22.5) hospital stay. Early viral exposure, older age, lymphocytopenia, and underlying conditions are risk factors which warrant aggressive intervention. Even though the virulence of SARS-CoV-2 appears decline over the course of serial transmissions, viral testing, contact tracing, social distancing, and face masking should be imposed on general public to contain viral dissemination from both symptomatic and asymptomatic patients with this highly contagious disease.http://dx.doi.org/10.1080/21505594.2020.1802870coronavirussars-cov-2covid-19incubation periodpandemicvirulence |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yinjie Gao Xuemei Ma Jingfeng Bi Jindong Chu Bo Liu Chunsheng Chi Jianguo Yan Xiaoli Yu Fangming Liu Xiaohong Deng Hongbing Zhang Bo Jin |
spellingShingle |
Yinjie Gao Xuemei Ma Jingfeng Bi Jindong Chu Bo Liu Chunsheng Chi Jianguo Yan Xiaoli Yu Fangming Liu Xiaohong Deng Hongbing Zhang Bo Jin Epidemiological and clinical differences of coronavirus disease 2019 patients with distinct viral exposure history Virulence coronavirus sars-cov-2 covid-19 incubation period pandemic virulence |
author_facet |
Yinjie Gao Xuemei Ma Jingfeng Bi Jindong Chu Bo Liu Chunsheng Chi Jianguo Yan Xiaoli Yu Fangming Liu Xiaohong Deng Hongbing Zhang Bo Jin |
author_sort |
Yinjie Gao |
title |
Epidemiological and clinical differences of coronavirus disease 2019 patients with distinct viral exposure history |
title_short |
Epidemiological and clinical differences of coronavirus disease 2019 patients with distinct viral exposure history |
title_full |
Epidemiological and clinical differences of coronavirus disease 2019 patients with distinct viral exposure history |
title_fullStr |
Epidemiological and clinical differences of coronavirus disease 2019 patients with distinct viral exposure history |
title_full_unstemmed |
Epidemiological and clinical differences of coronavirus disease 2019 patients with distinct viral exposure history |
title_sort |
epidemiological and clinical differences of coronavirus disease 2019 patients with distinct viral exposure history |
publisher |
Taylor & Francis Group |
series |
Virulence |
issn |
2150-5594 2150-5608 |
publishDate |
2020-01-01 |
description |
Since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread from the early epicenter, Wuhan, to the rest of China, the virulence of SARS-CoV-2 might have evolved at different phases of the pandemic. We therefore compared the unique features among 62 coronavirus disease 2019 (COVID-19) inpatients who contracted SARS-CoV-2 in Wuhan (15 cases), exposed to the patients from Wuhan (26 cases), or acquired the disease without exposure to Wuhan patients (21 cases). Median incubation periods are 4.5 days (3–5) for Wuhan patients, 8 days (3–11) for those infected by Wuhan patients, and 12 days (7–13) for those without aforementioned experience. The disease onset dates are earliest for Wuhan patients and latest for those without exposure to Wuhan patients. Blood lymphocytes were lowest in Wuhan patients, lower in those affected by Wuhan patients, and modest reduced in remaining ones. Disease severity is worst for Wuhan patients, and modest for those without contact with Wuhan patients. Wuhan patients had longest (27 days, 18–28), those transmitted by Wuhan patients had intermediate (16 days, 8–23), and the rest of the patients had shortest (13 days, 8.5–22.5) hospital stay. Early viral exposure, older age, lymphocytopenia, and underlying conditions are risk factors which warrant aggressive intervention. Even though the virulence of SARS-CoV-2 appears decline over the course of serial transmissions, viral testing, contact tracing, social distancing, and face masking should be imposed on general public to contain viral dissemination from both symptomatic and asymptomatic patients with this highly contagious disease. |
topic |
coronavirus sars-cov-2 covid-19 incubation period pandemic virulence |
url |
http://dx.doi.org/10.1080/21505594.2020.1802870 |
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