Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability
Introduction: Colorectal medullary carcinoma (MC) is a rare subtype of poorly differentiated adenocarcinoma (PDA) with unclear prognostic significance. Microsatellite instable (MSI) colorectal carcinomas have demonstrated better prognosis in clinical stage II. Aim: To analyze the survival and...
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doaj-0dee7cfcdb254c1ba1207985035ac5ef2020-11-25T01:09:37ZengTermedia Publishing HouseGastroenterology Review1895-57701897-43172016-12-0112320821410.5114/pg.2016.6474028944Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instabilityMiguel A. Gómez-ÁlvarezLeonardo S. Lino-SilvaRosa A. Salcedo-HernándezAlejandro Padilla-RoscianoErika B. Ruiz-GarcíaHoracio N. López-BasaveGerman Calderillo-RuizJosé M. Aguilar-RomeroJorge A. Domínguez-RodríguezÁngel Herrera-GómezAbelardo Meneses-GarcíaIntroduction: Colorectal medullary carcinoma (MC) is a rare subtype of poorly differentiated adenocarcinoma (PDA) with unclear prognostic significance. Microsatellite instable (MSI) colorectal carcinomas have demonstrated better prognosis in clinical stage II. Aim: To analyze the survival and clinicopathological characteristics of MCs versus PDAs with MSI in clinical stage III. Material and methods: We studied 22 cases of PDAs with MSI versus 10 MCs. Results : Of the 10 MCs, 7 patients were men; the mean age was 57.8 ±5.6 years. The mean tumor size was 9.6 ±4.1 cm, and the primary site was the right colon in 9; 7 patients showed lymph node metastases (LNM) and lymphovascular invasion (LVI). Of the 22 PDA cases, 12 (54.5%) were women with a mean age of 75 ±16.1 years. The mean tumor size was 6.4 ±3.2 cm. Twelve (54.5%) presented in the right colon, 21 (95.5%) showed LNM and 7 (31.8%) LVI. Follow-up was 32 ±8 months, with a 5-year overall survival of 42.9% for MCs and 76.6% for PDAs (p = 0.048). Univariate analysis found local recurrence (p = 0.001) and medullary subtype (p = 0.043) associated with lower survival. Conclusions : Medullary carcinomas were of greater tumor size and associated with more LVI and worse survival versus PDAs with MSI in stage III.https://www.termedia.pl/Medullary-colonic-carcinoma-with-microsatellite-instability-has-lower-survival-compared-with-conventional-colonic-adenocarcinoma-with-microsatellite-instability,41,28944,1,1.htmlcolorectal cancer microsatellite instability medullary carcinoma survival |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Miguel A. Gómez-Álvarez Leonardo S. Lino-Silva Rosa A. Salcedo-Hernández Alejandro Padilla-Rosciano Erika B. Ruiz-García Horacio N. López-Basave German Calderillo-Ruiz José M. Aguilar-Romero Jorge A. Domínguez-Rodríguez Ángel Herrera-Gómez Abelardo Meneses-García |
spellingShingle |
Miguel A. Gómez-Álvarez Leonardo S. Lino-Silva Rosa A. Salcedo-Hernández Alejandro Padilla-Rosciano Erika B. Ruiz-García Horacio N. López-Basave German Calderillo-Ruiz José M. Aguilar-Romero Jorge A. Domínguez-Rodríguez Ángel Herrera-Gómez Abelardo Meneses-García Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability Gastroenterology Review colorectal cancer microsatellite instability medullary carcinoma survival |
author_facet |
Miguel A. Gómez-Álvarez Leonardo S. Lino-Silva Rosa A. Salcedo-Hernández Alejandro Padilla-Rosciano Erika B. Ruiz-García Horacio N. López-Basave German Calderillo-Ruiz José M. Aguilar-Romero Jorge A. Domínguez-Rodríguez Ángel Herrera-Gómez Abelardo Meneses-García |
author_sort |
Miguel A. Gómez-Álvarez |
title |
Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability |
title_short |
Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability |
title_full |
Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability |
title_fullStr |
Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability |
title_full_unstemmed |
Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability |
title_sort |
medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability |
publisher |
Termedia Publishing House |
series |
Gastroenterology Review |
issn |
1895-5770 1897-4317 |
publishDate |
2016-12-01 |
description |
Introduction: Colorectal medullary carcinoma (MC) is a rare subtype of poorly differentiated adenocarcinoma (PDA) with unclear prognostic significance. Microsatellite instable (MSI) colorectal carcinomas have demonstrated better prognosis in clinical stage II.
Aim: To analyze the survival and clinicopathological characteristics of MCs versus PDAs with MSI in clinical stage III.
Material and methods: We studied 22 cases of PDAs with MSI versus 10 MCs.
Results : Of the 10 MCs, 7 patients were men; the mean age was 57.8 ±5.6 years. The mean tumor size was 9.6 ±4.1 cm, and the primary site was the right colon in 9; 7 patients showed lymph node metastases (LNM) and lymphovascular invasion (LVI). Of the 22 PDA cases, 12 (54.5%) were women with a mean age of 75 ±16.1 years. The mean tumor size was 6.4 ±3.2 cm. Twelve (54.5%) presented in the right colon, 21 (95.5%) showed LNM and 7 (31.8%) LVI. Follow-up was 32 ±8 months, with a 5-year overall survival of 42.9% for MCs and 76.6% for PDAs (p = 0.048). Univariate analysis found local recurrence (p = 0.001) and medullary subtype (p = 0.043) associated with lower survival.
Conclusions : Medullary carcinomas were of greater tumor size and associated with more LVI and worse survival versus PDAs with MSI in stage III. |
topic |
colorectal cancer microsatellite instability medullary carcinoma survival |
url |
https://www.termedia.pl/Medullary-colonic-carcinoma-with-microsatellite-instability-has-lower-survival-compared-with-conventional-colonic-adenocarcinoma-with-microsatellite-instability,41,28944,1,1.html |
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