The limit of tolerable micromotion for implant osseointegration: a systematic review
Abstract Much research effort is being invested into the development of porous biomaterials that enhance implant osseointegration. Large micromotions at the bone-implant interface impair this osseointegration process, resulting in fibrous capsule formation and implant loosening. This systematic revi...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-05-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-021-90142-5 |
id |
doaj-0df24780b5124cc4a52b7616fc197545 |
---|---|
record_format |
Article |
spelling |
doaj-0df24780b5124cc4a52b7616fc1975452021-05-30T11:35:48ZengNature Publishing GroupScientific Reports2045-23222021-05-0111111110.1038/s41598-021-90142-5The limit of tolerable micromotion for implant osseointegration: a systematic reviewNupur Kohli0Jennifer C. Stoddart1Richard J. van Arkel2Department of Mechanical Engineering, Imperial College LondonDepartment of Mechanical Engineering, Imperial College LondonDepartment of Mechanical Engineering, Imperial College LondonAbstract Much research effort is being invested into the development of porous biomaterials that enhance implant osseointegration. Large micromotions at the bone-implant interface impair this osseointegration process, resulting in fibrous capsule formation and implant loosening. This systematic review compiled all the in vivo evidence available to establish if there is a universal limit of tolerable micromotion for implant osseointegration. The protocol was registered with the International Prospective Register for Systematic Reviews (ID: CRD42020196686). Pubmed, Scopus and Web of Knowledge databases were searched for studies containing terms relating to micromotion and osseointegration. The mean value of micromotion for implants that osseointegrated was 32% of the mean value for those that did not (112 ± 176 µm versus 349 ± 231 µm, p < 0.001). However, there was a large overlap in the data ranges with no universal limit apparent. Rather, many factors were found to combine to affect the overall outcome including loading time, the type of implant and the material being used. The tables provided in this review summarise these factors and will aid investigators in identifying the most relevant micromotion values for their biomaterial and implant development research.https://doi.org/10.1038/s41598-021-90142-5 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nupur Kohli Jennifer C. Stoddart Richard J. van Arkel |
spellingShingle |
Nupur Kohli Jennifer C. Stoddart Richard J. van Arkel The limit of tolerable micromotion for implant osseointegration: a systematic review Scientific Reports |
author_facet |
Nupur Kohli Jennifer C. Stoddart Richard J. van Arkel |
author_sort |
Nupur Kohli |
title |
The limit of tolerable micromotion for implant osseointegration: a systematic review |
title_short |
The limit of tolerable micromotion for implant osseointegration: a systematic review |
title_full |
The limit of tolerable micromotion for implant osseointegration: a systematic review |
title_fullStr |
The limit of tolerable micromotion for implant osseointegration: a systematic review |
title_full_unstemmed |
The limit of tolerable micromotion for implant osseointegration: a systematic review |
title_sort |
limit of tolerable micromotion for implant osseointegration: a systematic review |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-05-01 |
description |
Abstract Much research effort is being invested into the development of porous biomaterials that enhance implant osseointegration. Large micromotions at the bone-implant interface impair this osseointegration process, resulting in fibrous capsule formation and implant loosening. This systematic review compiled all the in vivo evidence available to establish if there is a universal limit of tolerable micromotion for implant osseointegration. The protocol was registered with the International Prospective Register for Systematic Reviews (ID: CRD42020196686). Pubmed, Scopus and Web of Knowledge databases were searched for studies containing terms relating to micromotion and osseointegration. The mean value of micromotion for implants that osseointegrated was 32% of the mean value for those that did not (112 ± 176 µm versus 349 ± 231 µm, p < 0.001). However, there was a large overlap in the data ranges with no universal limit apparent. Rather, many factors were found to combine to affect the overall outcome including loading time, the type of implant and the material being used. The tables provided in this review summarise these factors and will aid investigators in identifying the most relevant micromotion values for their biomaterial and implant development research. |
url |
https://doi.org/10.1038/s41598-021-90142-5 |
work_keys_str_mv |
AT nupurkohli thelimitoftolerablemicromotionforimplantosseointegrationasystematicreview AT jennifercstoddart thelimitoftolerablemicromotionforimplantosseointegrationasystematicreview AT richardjvanarkel thelimitoftolerablemicromotionforimplantosseointegrationasystematicreview AT nupurkohli limitoftolerablemicromotionforimplantosseointegrationasystematicreview AT jennifercstoddart limitoftolerablemicromotionforimplantosseointegrationasystematicreview AT richardjvanarkel limitoftolerablemicromotionforimplantosseointegrationasystematicreview |
_version_ |
1721420124169175040 |