Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview
Influenza A viruses (IAVs) possess a great zoonotic potential as they are able to infect different avian and mammalian animal hosts, from which they can be transmitted to humans. This is based on the ability of IAV to gradually change their genome by mutation or even reassemble their genome segments...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2018-09-01
|
Series: | Viruses |
Subjects: | |
Online Access: | http://www.mdpi.com/1999-4915/10/9/497 |
id |
doaj-0e05d9569e814cbb8d195184f1daa981 |
---|---|
record_format |
Article |
spelling |
doaj-0e05d9569e814cbb8d195184f1daa9812020-11-24T21:46:37ZengMDPI AGViruses1999-49152018-09-0110949710.3390/v10090497v10090497Zoonotic Potential of Influenza A Viruses: A Comprehensive OverviewAhmed Mostafa0Elsayed M. Abdelwhab1Thomas C. Mettenleiter2Stephan Pleschka3Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392 Giessen, GermanyInstitute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Südufer 10, 17493 Greifswald-Insel Riems, GermanyInstitute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Südufer 10, 17493 Greifswald-Insel Riems, GermanyInstitute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392 Giessen, GermanyInfluenza A viruses (IAVs) possess a great zoonotic potential as they are able to infect different avian and mammalian animal hosts, from which they can be transmitted to humans. This is based on the ability of IAV to gradually change their genome by mutation or even reassemble their genome segments during co-infection of the host cell with different IAV strains, resulting in a high genetic diversity. Variants of circulating or newly emerging IAVs continue to trigger global health threats annually for both humans and animals. Here, we provide an introduction on IAVs, highlighting the mechanisms of viral evolution, the host spectrum, and the animal/human interface. Pathogenicity determinants of IAVs in mammals, with special emphasis on newly emerging IAVs with pandemic potential, are discussed. Finally, an overview is provided on various approaches for the prevention of human IAV infections.http://www.mdpi.com/1999-4915/10/9/497Influenza A viruszoonosispathogenicityevolutionpandemic |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ahmed Mostafa Elsayed M. Abdelwhab Thomas C. Mettenleiter Stephan Pleschka |
spellingShingle |
Ahmed Mostafa Elsayed M. Abdelwhab Thomas C. Mettenleiter Stephan Pleschka Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview Viruses Influenza A virus zoonosis pathogenicity evolution pandemic |
author_facet |
Ahmed Mostafa Elsayed M. Abdelwhab Thomas C. Mettenleiter Stephan Pleschka |
author_sort |
Ahmed Mostafa |
title |
Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview |
title_short |
Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview |
title_full |
Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview |
title_fullStr |
Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview |
title_full_unstemmed |
Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview |
title_sort |
zoonotic potential of influenza a viruses: a comprehensive overview |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2018-09-01 |
description |
Influenza A viruses (IAVs) possess a great zoonotic potential as they are able to infect different avian and mammalian animal hosts, from which they can be transmitted to humans. This is based on the ability of IAV to gradually change their genome by mutation or even reassemble their genome segments during co-infection of the host cell with different IAV strains, resulting in a high genetic diversity. Variants of circulating or newly emerging IAVs continue to trigger global health threats annually for both humans and animals. Here, we provide an introduction on IAVs, highlighting the mechanisms of viral evolution, the host spectrum, and the animal/human interface. Pathogenicity determinants of IAVs in mammals, with special emphasis on newly emerging IAVs with pandemic potential, are discussed. Finally, an overview is provided on various approaches for the prevention of human IAV infections. |
topic |
Influenza A virus zoonosis pathogenicity evolution pandemic |
url |
http://www.mdpi.com/1999-4915/10/9/497 |
work_keys_str_mv |
AT ahmedmostafa zoonoticpotentialofinfluenzaavirusesacomprehensiveoverview AT elsayedmabdelwhab zoonoticpotentialofinfluenzaavirusesacomprehensiveoverview AT thomascmettenleiter zoonoticpotentialofinfluenzaavirusesacomprehensiveoverview AT stephanpleschka zoonoticpotentialofinfluenzaavirusesacomprehensiveoverview |
_version_ |
1725901030072254464 |