Utility of induction agents in living donor kidney transplantation
Aim: The outcome and long-term adverse events associated with induction agent use for living donor (LD) kidney transplantation (KT) in India were studied. Materials and Methods: Consecutive LD kidney transplant recipients (KTRs) from 2005 to 2013 were studied. They were divided based on induction ag...
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Wolters Kluwer Medknow Publications
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doaj-0e07d78430944a54ada2fb97b7d5a2222020-11-25T02:13:27ZengWolters Kluwer Medknow PublicationsIndian Journal of Transplantation2212-00172212-00252019-01-0113320220910.4103/ijot.ijot_17_19Utility of induction agents in living donor kidney transplantationRadhika Chemmangattu RadhakrishnanGopal BasuAnjali MohapatraSuceena AlexanderAnna T ValsonShibu JacobVinoi George DavidSantosh VarugheseTamilarasi VeerasamiAim: The outcome and long-term adverse events associated with induction agent use for living donor (LD) kidney transplantation (KT) in India were studied. Materials and Methods: Consecutive LD kidney transplant recipients (KTRs) from 2005 to 2013 were studied. They were divided based on induction agent use, into induction group and no induction group. The induction group was further subdivided into those receiving antithymocyte globulin (ATG group) and those receiving basiliximab (IL-2RB group). Study subjects were also classified into high and low immunological risk groups. Outcomes evaluated were patient and graft survival, acute rejections, infections, leucopenia, malignancy, new-onset diabetes mellitus, antibody-mediated rejections, and 1-year serum creatinine. Results: Of 605 LD-KTRs, 445 (73.6%) received induction. 403 (90.6%) received basiliximab induction. There was significant improvement in patient and graft survival in induction group (log rank P = 0.041 and 0.024, respectively), but this benefit disappeared when adjusting for immunosuppressive regimen as well as when only patients on tacrolimus-mycophenolate (Tac-MPA) were considered. There was significant reduction in acute rejections, tuberculosis (TB), and BK viremia in the induction group even in patients receiving Tac-MPA. There was no significant difference between basiliximab and ATG except for increased risk of BK viremia with ATG. Conclusions: The use of induction agents is associated with reduced incidence of acute rejections and serious infections (TB and BK viremia). The survival benefit of induction agent use is lost with the Tac-MPA-based immunosuppression. Thus, induction agent use is not essential for better survival if using Tac-MPA-based regimen.http://www.ijtonline.in/article.asp?issn=2212-0017;year=2019;volume=13;issue=3;spage=202;epage=209;aulast=RadhakrishnanAntithymocyte globulinbasiliximabinductioninterleukin-2 receptor blockerkidney transplantation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Radhika Chemmangattu Radhakrishnan Gopal Basu Anjali Mohapatra Suceena Alexander Anna T Valson Shibu Jacob Vinoi George David Santosh Varughese Tamilarasi Veerasami |
spellingShingle |
Radhika Chemmangattu Radhakrishnan Gopal Basu Anjali Mohapatra Suceena Alexander Anna T Valson Shibu Jacob Vinoi George David Santosh Varughese Tamilarasi Veerasami Utility of induction agents in living donor kidney transplantation Indian Journal of Transplantation Antithymocyte globulin basiliximab induction interleukin-2 receptor blocker kidney transplantation |
author_facet |
Radhika Chemmangattu Radhakrishnan Gopal Basu Anjali Mohapatra Suceena Alexander Anna T Valson Shibu Jacob Vinoi George David Santosh Varughese Tamilarasi Veerasami |
author_sort |
Radhika Chemmangattu Radhakrishnan |
title |
Utility of induction agents in living donor kidney transplantation |
title_short |
Utility of induction agents in living donor kidney transplantation |
title_full |
Utility of induction agents in living donor kidney transplantation |
title_fullStr |
Utility of induction agents in living donor kidney transplantation |
title_full_unstemmed |
Utility of induction agents in living donor kidney transplantation |
title_sort |
utility of induction agents in living donor kidney transplantation |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Transplantation |
issn |
2212-0017 2212-0025 |
publishDate |
2019-01-01 |
description |
Aim: The outcome and long-term adverse events associated with induction agent use for living donor (LD) kidney transplantation (KT) in India were studied. Materials and Methods: Consecutive LD kidney transplant recipients (KTRs) from 2005 to 2013 were studied. They were divided based on induction agent use, into induction group and no induction group. The induction group was further subdivided into those receiving antithymocyte globulin (ATG group) and those receiving basiliximab (IL-2RB group). Study subjects were also classified into high and low immunological risk groups. Outcomes evaluated were patient and graft survival, acute rejections, infections, leucopenia, malignancy, new-onset diabetes mellitus, antibody-mediated rejections, and 1-year serum creatinine. Results: Of 605 LD-KTRs, 445 (73.6%) received induction. 403 (90.6%) received basiliximab induction. There was significant improvement in patient and graft survival in induction group (log rank P = 0.041 and 0.024, respectively), but this benefit disappeared when adjusting for immunosuppressive regimen as well as when only patients on tacrolimus-mycophenolate (Tac-MPA) were considered. There was significant reduction in acute rejections, tuberculosis (TB), and BK viremia in the induction group even in patients receiving Tac-MPA. There was no significant difference between basiliximab and ATG except for increased risk of BK viremia with ATG. Conclusions: The use of induction agents is associated with reduced incidence of acute rejections and serious infections (TB and BK viremia). The survival benefit of induction agent use is lost with the Tac-MPA-based immunosuppression. Thus, induction agent use is not essential for better survival if using Tac-MPA-based regimen. |
topic |
Antithymocyte globulin basiliximab induction interleukin-2 receptor blocker kidney transplantation |
url |
http://www.ijtonline.in/article.asp?issn=2212-0017;year=2019;volume=13;issue=3;spage=202;epage=209;aulast=Radhakrishnan |
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