Indirubin derivatives are potent and selective anti-Trypanosoma cruzi agents

Indirubin derivatives are potent and selective anti-Trypanosoma cruzi agents

Current treatment for combatting Chagas disease, a life-threatening illness caused by the kinetoplastid protozoan parasite Trypanosoma cruzi is inadequate, and thus the discovery of new antiparasitic compounds is of prime importance. Previous studies identified the indirubins, a class of ATP kinase...

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Bibliographic Details
Main Authors: Antonia Efstathiou, Cássio Santana Meira, Nicolas Gaboriaud-Kolar, Tanira Matutino Bastos, Vinícius Pinto Costa Rocha, Konstantina Vougogiannopoulou, Alexios-Leandros Skaltsounis, Despina Smirlis, Milena Botelho Pereira Soares
Format: Article
Language:English
Published: Taylor & Francis Group 2018-12-01
Series:Virulence
Subjects:
Indirubins
T. cruzi
antiparasitic
in vivo efficacy
Online Access:http://dx.doi.org/10.1080/21505594.2018.1532242

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