Food Consumption as a Modifier of the Association between LEPR Gene Variants and Excess Body Weight in Children and Adolescents: A Study of the SCAALA Cohort
No studies showing that food consumption is a modifier of the association of variants of the leptin receptor gene (LEPR) with body weight have involved a Brazilian population. The aim of this study was to evaluate the modifying effect of dietary intake on the association between the LEPR gene and ex...
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doaj-0e12c1755efc4539a491f1ef75032ade2020-11-24T20:43:52ZengMDPI AGNutrients2072-66432018-08-01108111710.3390/nu10081117nu10081117Food Consumption as a Modifier of the Association between LEPR Gene Variants and Excess Body Weight in Children and Adolescents: A Study of the SCAALA CohortAline dos Santos Rocha0Rita de Cássia Ribeiro-Silva1Gustavo Nunes de Oliveira Costa2Camila Alexandrina Figueiredo3Laura Cunha Rodrigues4Sheila Maria Alvim Matos5Rosemeire Leovigildo Fiaccone6Pablo Rafael Oliveira7Nadya Helena Alves-Santos8Ronald E. Blanton9Maurício Lima Barreto10Departamento Ciência da Nutrição, Escola de Nutrição, Universidade Federal da Bahia, Av. Araújo Pinho, 32, Canela, CEP: 40.110-150, Salvador, BA BrasilDepartamento Ciência da Nutrição, Escola de Nutrição, Universidade Federal da Bahia, Av. Araújo Pinho, 32, Canela, CEP: 40.110-150, Salvador, BA BrasilInstituto Gonçalo Moniz (IGM), Fundação Osvaldo Cruz—FIOCRUZ-Bahia, Av. Waldemar Falcão, 121, Candeal-Salvador/BA, CEP: 40296-710, Salvador, BA, BrasilDepartamento de Ciências da Biorregulação, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Av. Reitor Miguel Calmon. s/n, Vale do Canela, CEP: 40110-100, Salvador, BA, BrasilDepartment of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine (LSHTM), Keppel Street, London, WC1E 7HT UKInstituto de Saúde Coletiva, Universidade Federal da Bahia, Rua Basílio da Gama, s/n, Canela, CEP:40.110-040, Salvador, BA, BrasilInstituto de Saúde Coletiva, Universidade Federal da Bahia, Rua Basílio da Gama, s/n, Canela, CEP:40.110-040, Salvador, BA, BrasilInstituto Gonçalo Moniz (IGM), Fundação Osvaldo Cruz—FIOCRUZ-Bahia, Av. Waldemar Falcão, 121, Candeal-Salvador/BA, CEP: 40296-710, Salvador, BA, BrasilObservatório de Epidemiologia Nutricional, Departamento de Nutrição Aplicada e Social, Instituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro-UERJ. CEP: 21941-590, Rio de Janeiro, RJ, BrasilCenter for Global Health & Diseases, Biomedical Research Building (BRB), Room 425, Case Western Reserve University, 2109 Adelbert Rd, Cleveland, OH 44106, USAInstituto Gonçalo Moniz (IGM), Fundação Osvaldo Cruz—FIOCRUZ-Bahia, Av. Waldemar Falcão, 121, Candeal-Salvador/BA, CEP: 40296-710, Salvador, BA, BrasilNo studies showing that food consumption is a modifier of the association of variants of the leptin receptor gene (LEPR) with body weight have involved a Brazilian population. The aim of this study was to evaluate the modifying effect of dietary intake on the association between the LEPR gene and excess weight. In this study, 1211 children and adolescents aged 4–11 years were assessed. Participants were genotyped for 112 single-nucleotide variants of the LEPR gene. Anthropometric measurements were performed, and dietary data were obtained. Logistic regressions were used to study the associations of interest. Of the participants, 13.4% were overweight/obese. The risk allele (G) of the rs1137100 variant was associated with excess weight in individuals with fat consumption below the median (odds ratio OR = 1.92; 95% confidence interval CI = 1.18–3.14), with daily frequency of consumption of drink/artificial juice (OR = 2.15; 95% CI = 1.26–3.68) and refined cereals (OR = 2.17; 95% CI = 1.31–3.62) above the median. The risk allele (G) of variant rs1177681 was also associated with excess weight (OR = 2.74; 95% CI = 1.65–4.57) in subjects with a daily frequency of refined cereal consumption above the median. The association between LEPR and excess weight can be modulated by the type and distribution of dietary fatty acids, sugary drinks, and refined cereals.http://www.mdpi.com/2072-6643/10/8/1117overweightobesityleptin receptor genechildren and adolescentsfood consumption |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aline dos Santos Rocha Rita de Cássia Ribeiro-Silva Gustavo Nunes de Oliveira Costa Camila Alexandrina Figueiredo Laura Cunha Rodrigues Sheila Maria Alvim Matos Rosemeire Leovigildo Fiaccone Pablo Rafael Oliveira Nadya Helena Alves-Santos Ronald E. Blanton Maurício Lima Barreto |
spellingShingle |
Aline dos Santos Rocha Rita de Cássia Ribeiro-Silva Gustavo Nunes de Oliveira Costa Camila Alexandrina Figueiredo Laura Cunha Rodrigues Sheila Maria Alvim Matos Rosemeire Leovigildo Fiaccone Pablo Rafael Oliveira Nadya Helena Alves-Santos Ronald E. Blanton Maurício Lima Barreto Food Consumption as a Modifier of the Association between LEPR Gene Variants and Excess Body Weight in Children and Adolescents: A Study of the SCAALA Cohort Nutrients overweight obesity leptin receptor gene children and adolescents food consumption |
author_facet |
Aline dos Santos Rocha Rita de Cássia Ribeiro-Silva Gustavo Nunes de Oliveira Costa Camila Alexandrina Figueiredo Laura Cunha Rodrigues Sheila Maria Alvim Matos Rosemeire Leovigildo Fiaccone Pablo Rafael Oliveira Nadya Helena Alves-Santos Ronald E. Blanton Maurício Lima Barreto |
author_sort |
Aline dos Santos Rocha |
title |
Food Consumption as a Modifier of the Association between LEPR Gene Variants and Excess Body Weight in Children and Adolescents: A Study of the SCAALA Cohort |
title_short |
Food Consumption as a Modifier of the Association between LEPR Gene Variants and Excess Body Weight in Children and Adolescents: A Study of the SCAALA Cohort |
title_full |
Food Consumption as a Modifier of the Association between LEPR Gene Variants and Excess Body Weight in Children and Adolescents: A Study of the SCAALA Cohort |
title_fullStr |
Food Consumption as a Modifier of the Association between LEPR Gene Variants and Excess Body Weight in Children and Adolescents: A Study of the SCAALA Cohort |
title_full_unstemmed |
Food Consumption as a Modifier of the Association between LEPR Gene Variants and Excess Body Weight in Children and Adolescents: A Study of the SCAALA Cohort |
title_sort |
food consumption as a modifier of the association between lepr gene variants and excess body weight in children and adolescents: a study of the scaala cohort |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2018-08-01 |
description |
No studies showing that food consumption is a modifier of the association of variants of the leptin receptor gene (LEPR) with body weight have involved a Brazilian population. The aim of this study was to evaluate the modifying effect of dietary intake on the association between the LEPR gene and excess weight. In this study, 1211 children and adolescents aged 4–11 years were assessed. Participants were genotyped for 112 single-nucleotide variants of the LEPR gene. Anthropometric measurements were performed, and dietary data were obtained. Logistic regressions were used to study the associations of interest. Of the participants, 13.4% were overweight/obese. The risk allele (G) of the rs1137100 variant was associated with excess weight in individuals with fat consumption below the median (odds ratio OR = 1.92; 95% confidence interval CI = 1.18–3.14), with daily frequency of consumption of drink/artificial juice (OR = 2.15; 95% CI = 1.26–3.68) and refined cereals (OR = 2.17; 95% CI = 1.31–3.62) above the median. The risk allele (G) of variant rs1177681 was also associated with excess weight (OR = 2.74; 95% CI = 1.65–4.57) in subjects with a daily frequency of refined cereal consumption above the median. The association between LEPR and excess weight can be modulated by the type and distribution of dietary fatty acids, sugary drinks, and refined cereals. |
topic |
overweight obesity leptin receptor gene children and adolescents food consumption |
url |
http://www.mdpi.com/2072-6643/10/8/1117 |
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