Effects of Urate-Lowering Therapy on Risk of Hyperlipidemia in Gout by a Population-Based Cohort Study and on In Vitro Hepatic Lipogenesis-Related Gene Expression
Patients with gout are at a higher risk of cardiovascular disease, which is associated with hyperlipidemia. Management of gout in Taiwan is poor, and the association between urate-lowering therapy (ULT) among gout patients and hyperlipidemia is unclear. We conducted a retrospective cohort study usin...
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doaj-0e13b308b0e14117b812ab0f4fd83e472020-11-30T09:11:28ZengHindawi LimitedMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/88903008890300Effects of Urate-Lowering Therapy on Risk of Hyperlipidemia in Gout by a Population-Based Cohort Study and on In Vitro Hepatic Lipogenesis-Related Gene ExpressionYi-Jen Fang0Tien-Yuan Wu1Cheng-Li Lin2Chih-Yang Su3Jia-Rong Li4Yun-Lung Chung5Ni Tien6Yun-Ping Lim7Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Pharmacy, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, TaiwanManagement Office for Health Data, China Medical University Hospital, Taichung, TaiwanMaster Program for Pharmaceutical Manufacture, College of Pharmacy, China Medical University, Taichung, TaiwanMaster Program for Pharmaceutical Manufacture, College of Pharmacy, China Medical University, Taichung, TaiwanResearch Assistant Center, Show Chwan Health Care System, Changhua, TaiwanDepartment of Laboratory Medicine, China Medical University Hospital, Taichung, TaiwanDepartment of Pharmacy, College of Pharmacy, China Medical University, Taichung, TaiwanPatients with gout are at a higher risk of cardiovascular disease, which is associated with hyperlipidemia. Management of gout in Taiwan is poor, and the association between urate-lowering therapy (ULT) among gout patients and hyperlipidemia is unclear. We conducted a retrospective cohort study using data from the Longitudinal Health Insurance Database (LHID) of Taiwan on new-onset gout patients and a comparison cohort without gout. A Cox proportional hazards model was used to analyze differences in the risk of hyperlipidemia between patients with and without gout after considering related comorbidities. We also examined the ULT medications on the hepatic expression of lipogenesis-related genes. After adjusting for potential confounders, the case group (44,413 patients) was found to have a higher risk of hyperlipidemia than the control cohort (177,652 patients) [adjusted hazards ratio aHR=2.55]. Gout patients without antigout treatment had significantly higher risk of hyperlipidemia than the control cohort (aHR=3.10). Among gout patients receiving ULT, except those receiving probenecid (aHR=0.80), all had significantly lower risk of hyperlipidemia than gout patients without ULT (all aHR<0.90). Using real-time polymerase chain reaction, we found that most of the antigout drugs decreased the expression of hepatic genes related to lipogenesis in differentiated HepaRG cells. These data indicate that these antigout drugs reduce hyperlipidemia in gout patients, partly via the reduction in expression of lipogenesis-related genes, leading to improved blood lipid profiles. We provide evidence of the strong association between gout and hyperlipidemia and highlight the need for appropriate treatment guidelines.http://dx.doi.org/10.1155/2020/8890300 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yi-Jen Fang Tien-Yuan Wu Cheng-Li Lin Chih-Yang Su Jia-Rong Li Yun-Lung Chung Ni Tien Yun-Ping Lim |
spellingShingle |
Yi-Jen Fang Tien-Yuan Wu Cheng-Li Lin Chih-Yang Su Jia-Rong Li Yun-Lung Chung Ni Tien Yun-Ping Lim Effects of Urate-Lowering Therapy on Risk of Hyperlipidemia in Gout by a Population-Based Cohort Study and on In Vitro Hepatic Lipogenesis-Related Gene Expression Mediators of Inflammation |
author_facet |
Yi-Jen Fang Tien-Yuan Wu Cheng-Li Lin Chih-Yang Su Jia-Rong Li Yun-Lung Chung Ni Tien Yun-Ping Lim |
author_sort |
Yi-Jen Fang |
title |
Effects of Urate-Lowering Therapy on Risk of Hyperlipidemia in Gout by a Population-Based Cohort Study and on In Vitro Hepatic Lipogenesis-Related Gene Expression |
title_short |
Effects of Urate-Lowering Therapy on Risk of Hyperlipidemia in Gout by a Population-Based Cohort Study and on In Vitro Hepatic Lipogenesis-Related Gene Expression |
title_full |
Effects of Urate-Lowering Therapy on Risk of Hyperlipidemia in Gout by a Population-Based Cohort Study and on In Vitro Hepatic Lipogenesis-Related Gene Expression |
title_fullStr |
Effects of Urate-Lowering Therapy on Risk of Hyperlipidemia in Gout by a Population-Based Cohort Study and on In Vitro Hepatic Lipogenesis-Related Gene Expression |
title_full_unstemmed |
Effects of Urate-Lowering Therapy on Risk of Hyperlipidemia in Gout by a Population-Based Cohort Study and on In Vitro Hepatic Lipogenesis-Related Gene Expression |
title_sort |
effects of urate-lowering therapy on risk of hyperlipidemia in gout by a population-based cohort study and on in vitro hepatic lipogenesis-related gene expression |
publisher |
Hindawi Limited |
series |
Mediators of Inflammation |
issn |
0962-9351 1466-1861 |
publishDate |
2020-01-01 |
description |
Patients with gout are at a higher risk of cardiovascular disease, which is associated with hyperlipidemia. Management of gout in Taiwan is poor, and the association between urate-lowering therapy (ULT) among gout patients and hyperlipidemia is unclear. We conducted a retrospective cohort study using data from the Longitudinal Health Insurance Database (LHID) of Taiwan on new-onset gout patients and a comparison cohort without gout. A Cox proportional hazards model was used to analyze differences in the risk of hyperlipidemia between patients with and without gout after considering related comorbidities. We also examined the ULT medications on the hepatic expression of lipogenesis-related genes. After adjusting for potential confounders, the case group (44,413 patients) was found to have a higher risk of hyperlipidemia than the control cohort (177,652 patients) [adjusted hazards ratio aHR=2.55]. Gout patients without antigout treatment had significantly higher risk of hyperlipidemia than the control cohort (aHR=3.10). Among gout patients receiving ULT, except those receiving probenecid (aHR=0.80), all had significantly lower risk of hyperlipidemia than gout patients without ULT (all aHR<0.90). Using real-time polymerase chain reaction, we found that most of the antigout drugs decreased the expression of hepatic genes related to lipogenesis in differentiated HepaRG cells. These data indicate that these antigout drugs reduce hyperlipidemia in gout patients, partly via the reduction in expression of lipogenesis-related genes, leading to improved blood lipid profiles. We provide evidence of the strong association between gout and hyperlipidemia and highlight the need for appropriate treatment guidelines. |
url |
http://dx.doi.org/10.1155/2020/8890300 |
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