Crossover patterning by the beam-film model: analysis and implications.
Crossing-over is a central feature of meiosis. Meiotic crossover (CO) sites are spatially patterned along chromosomes. CO-designation at one position disfavors subsequent CO-designation(s) nearby, as described by the classical phenomenon of CO interference. If multiple designations occur, COs tend t...
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doaj-0e1ba47b67014841b915fc9c40dd01bd2020-11-25T02:12:46ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042014-01-01101e100404210.1371/journal.pgen.1004042Crossover patterning by the beam-film model: analysis and implications.Liangran ZhangZhangyi LiangJohn HutchinsonNancy KlecknerCrossing-over is a central feature of meiosis. Meiotic crossover (CO) sites are spatially patterned along chromosomes. CO-designation at one position disfavors subsequent CO-designation(s) nearby, as described by the classical phenomenon of CO interference. If multiple designations occur, COs tend to be evenly spaced. We have previously proposed a mechanical model by which CO patterning could occur. The central feature of a mechanical mechanism is that communication along the chromosomes, as required for CO interference, can occur by redistribution of mechanical stress. Here we further explore the nature of the beam-film model, its ability to quantitatively explain CO patterns in detail in several organisms, and its implications for three important patterning-related phenomena: CO homeostasis, the fact that the level of zero-CO bivalents can be low (the "obligatory CO"), and the occurrence of non-interfering COs. Relationships to other models are discussed.http://europepmc.org/articles/PMC3907302?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Liangran Zhang Zhangyi Liang John Hutchinson Nancy Kleckner |
spellingShingle |
Liangran Zhang Zhangyi Liang John Hutchinson Nancy Kleckner Crossover patterning by the beam-film model: analysis and implications. PLoS Genetics |
author_facet |
Liangran Zhang Zhangyi Liang John Hutchinson Nancy Kleckner |
author_sort |
Liangran Zhang |
title |
Crossover patterning by the beam-film model: analysis and implications. |
title_short |
Crossover patterning by the beam-film model: analysis and implications. |
title_full |
Crossover patterning by the beam-film model: analysis and implications. |
title_fullStr |
Crossover patterning by the beam-film model: analysis and implications. |
title_full_unstemmed |
Crossover patterning by the beam-film model: analysis and implications. |
title_sort |
crossover patterning by the beam-film model: analysis and implications. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Genetics |
issn |
1553-7390 1553-7404 |
publishDate |
2014-01-01 |
description |
Crossing-over is a central feature of meiosis. Meiotic crossover (CO) sites are spatially patterned along chromosomes. CO-designation at one position disfavors subsequent CO-designation(s) nearby, as described by the classical phenomenon of CO interference. If multiple designations occur, COs tend to be evenly spaced. We have previously proposed a mechanical model by which CO patterning could occur. The central feature of a mechanical mechanism is that communication along the chromosomes, as required for CO interference, can occur by redistribution of mechanical stress. Here we further explore the nature of the beam-film model, its ability to quantitatively explain CO patterns in detail in several organisms, and its implications for three important patterning-related phenomena: CO homeostasis, the fact that the level of zero-CO bivalents can be low (the "obligatory CO"), and the occurrence of non-interfering COs. Relationships to other models are discussed. |
url |
http://europepmc.org/articles/PMC3907302?pdf=render |
work_keys_str_mv |
AT liangranzhang crossoverpatterningbythebeamfilmmodelanalysisandimplications AT zhangyiliang crossoverpatterningbythebeamfilmmodelanalysisandimplications AT johnhutchinson crossoverpatterningbythebeamfilmmodelanalysisandimplications AT nancykleckner crossoverpatterningbythebeamfilmmodelanalysisandimplications |
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1724908376354193408 |