A single NaK channel conformation is not enough for non-selective ion conduction
NaK is a non-selective cation channel that conducts sodium (Na+) and potassium (K+) equally well. Here authors use ssNMR and MD simulations to show that the selectivity filter of NaK adopts two conformations in the absence of ions, one of which is preferred by Na+ and the other by K+.
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2018-02-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-03179-y |
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doaj-0e20ab2b76714568a57a0701df6d99022021-05-11T09:21:06ZengNature Publishing GroupNature Communications2041-17232018-02-01911810.1038/s41467-018-03179-yA single NaK channel conformation is not enough for non-selective ion conductionChaowei Shi0Yao He1Kitty Hendriks2Bert L. de Groot3Xiaoying Cai4Changlin Tian5Adam Lange6Han Sun7Department of Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare PharmakologieHefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of ChinaDepartment of Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare PharmakologieBiomolecular Dynamics Group, Max Planck Institute for Biophysical ChemistryHefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of ChinaDepartment of Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare PharmakologieSection Structural Biology, Leibniz-Forschungsinstitut für Molekulare PharmakologieNaK is a non-selective cation channel that conducts sodium (Na+) and potassium (K+) equally well. Here authors use ssNMR and MD simulations to show that the selectivity filter of NaK adopts two conformations in the absence of ions, one of which is preferred by Na+ and the other by K+.https://doi.org/10.1038/s41467-018-03179-y |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chaowei Shi Yao He Kitty Hendriks Bert L. de Groot Xiaoying Cai Changlin Tian Adam Lange Han Sun |
spellingShingle |
Chaowei Shi Yao He Kitty Hendriks Bert L. de Groot Xiaoying Cai Changlin Tian Adam Lange Han Sun A single NaK channel conformation is not enough for non-selective ion conduction Nature Communications |
author_facet |
Chaowei Shi Yao He Kitty Hendriks Bert L. de Groot Xiaoying Cai Changlin Tian Adam Lange Han Sun |
author_sort |
Chaowei Shi |
title |
A single NaK channel conformation is not enough for non-selective ion conduction |
title_short |
A single NaK channel conformation is not enough for non-selective ion conduction |
title_full |
A single NaK channel conformation is not enough for non-selective ion conduction |
title_fullStr |
A single NaK channel conformation is not enough for non-selective ion conduction |
title_full_unstemmed |
A single NaK channel conformation is not enough for non-selective ion conduction |
title_sort |
single nak channel conformation is not enough for non-selective ion conduction |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2018-02-01 |
description |
NaK is a non-selective cation channel that conducts sodium (Na+) and potassium (K+) equally well. Here authors use ssNMR and MD simulations to show that the selectivity filter of NaK adopts two conformations in the absence of ions, one of which is preferred by Na+ and the other by K+. |
url |
https://doi.org/10.1038/s41467-018-03179-y |
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