A single NaK channel conformation is not enough for non-selective ion conduction

NaK is a non-selective cation channel that conducts sodium (Na+) and potassium (K+) equally well. Here authors use ssNMR and MD simulations to show that the selectivity filter of NaK adopts two conformations in the absence of ions, one of which is preferred by Na+ and the other by K+.

Bibliographic Details
Main Authors:	Chaowei Shi, Yao He, Kitty Hendriks, Bert L. de Groot, Xiaoying Cai, Changlin Tian, Adam Lange, Han Sun
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-03179-y

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spelling	doaj-0e20ab2b76714568a57a0701df6d99022021-05-11T09:21:06ZengNature Publishing GroupNature Communications2041-17232018-02-01911810.1038/s41467-018-03179-yA single NaK channel conformation is not enough for non-selective ion conductionChaowei Shi0Yao He1Kitty Hendriks2Bert L. de Groot3Xiaoying Cai4Changlin Tian5Adam Lange6Han Sun7Department of Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare PharmakologieHefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of ChinaDepartment of Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare PharmakologieBiomolecular Dynamics Group, Max Planck Institute for Biophysical ChemistryHefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of ChinaDepartment of Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare PharmakologieSection Structural Biology, Leibniz-Forschungsinstitut für Molekulare PharmakologieNaK is a non-selective cation channel that conducts sodium (Na+) and potassium (K+) equally well. Here authors use ssNMR and MD simulations to show that the selectivity filter of NaK adopts two conformations in the absence of ions, one of which is preferred by Na+ and the other by K+.https://doi.org/10.1038/s41467-018-03179-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Chaowei Shi Yao He Kitty Hendriks Bert L. de Groot Xiaoying Cai Changlin Tian Adam Lange Han Sun
spellingShingle	Chaowei Shi Yao He Kitty Hendriks Bert L. de Groot Xiaoying Cai Changlin Tian Adam Lange Han Sun A single NaK channel conformation is not enough for non-selective ion conduction Nature Communications
author_facet	Chaowei Shi Yao He Kitty Hendriks Bert L. de Groot Xiaoying Cai Changlin Tian Adam Lange Han Sun
author_sort	Chaowei Shi
title	A single NaK channel conformation is not enough for non-selective ion conduction
title_short	A single NaK channel conformation is not enough for non-selective ion conduction
title_full	A single NaK channel conformation is not enough for non-selective ion conduction
title_fullStr	A single NaK channel conformation is not enough for non-selective ion conduction
title_full_unstemmed	A single NaK channel conformation is not enough for non-selective ion conduction
title_sort	single nak channel conformation is not enough for non-selective ion conduction
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-02-01
description	NaK is a non-selective cation channel that conducts sodium (Na+) and potassium (K+) equally well. Here authors use ssNMR and MD simulations to show that the selectivity filter of NaK adopts two conformations in the absence of ions, one of which is preferred by Na+ and the other by K+.
url	https://doi.org/10.1038/s41467-018-03179-y
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A single NaK channel conformation is not enough for non-selective ion conduction

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