Systemic muscle wasting and coordinated tumour response drive tumourigenesis

Cancer is a systemic disease that associates with host metabolic changes. Here, the authors show using Drosophila, that tumours exploit extracellular proline in response to muscle wasting, indicating that tumours induce muscle wasting as a nutrient-scavenging programme to drive tumourigenesis.

Bibliographic Details
Main Authors:	Holly Newton, Yi-Fang Wang, Laura Camplese, Joao B. Mokochinski, Holger B. Kramer, André E. X. Brown, Louise Fets, Susumu Hirabayashi
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18502-9

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spelling	doaj-0e28b218bcbf4e1a9a38907a77d327a92021-09-19T11:50:45ZengNature Publishing GroupNature Communications2041-17232020-09-0111111310.1038/s41467-020-18502-9Systemic muscle wasting and coordinated tumour response drive tumourigenesisHolly Newton0Yi-Fang Wang1Laura Camplese2Joao B. Mokochinski3Holger B. Kramer4André E. X. Brown5Louise Fets6Susumu Hirabayashi7Medical Research Council London Institute of Medical SciencesMedical Research Council London Institute of Medical SciencesMedical Research Council London Institute of Medical SciencesMedical Research Council London Institute of Medical SciencesMedical Research Council London Institute of Medical SciencesMedical Research Council London Institute of Medical SciencesMedical Research Council London Institute of Medical SciencesMedical Research Council London Institute of Medical SciencesCancer is a systemic disease that associates with host metabolic changes. Here, the authors show using Drosophila, that tumours exploit extracellular proline in response to muscle wasting, indicating that tumours induce muscle wasting as a nutrient-scavenging programme to drive tumourigenesis.https://doi.org/10.1038/s41467-020-18502-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Holly Newton Yi-Fang Wang Laura Camplese Joao B. Mokochinski Holger B. Kramer André E. X. Brown Louise Fets Susumu Hirabayashi
spellingShingle	Holly Newton Yi-Fang Wang Laura Camplese Joao B. Mokochinski Holger B. Kramer André E. X. Brown Louise Fets Susumu Hirabayashi Systemic muscle wasting and coordinated tumour response drive tumourigenesis Nature Communications
author_facet	Holly Newton Yi-Fang Wang Laura Camplese Joao B. Mokochinski Holger B. Kramer André E. X. Brown Louise Fets Susumu Hirabayashi
author_sort	Holly Newton
title	Systemic muscle wasting and coordinated tumour response drive tumourigenesis
title_short	Systemic muscle wasting and coordinated tumour response drive tumourigenesis
title_full	Systemic muscle wasting and coordinated tumour response drive tumourigenesis
title_fullStr	Systemic muscle wasting and coordinated tumour response drive tumourigenesis
title_full_unstemmed	Systemic muscle wasting and coordinated tumour response drive tumourigenesis
title_sort	systemic muscle wasting and coordinated tumour response drive tumourigenesis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-09-01
description	Cancer is a systemic disease that associates with host metabolic changes. Here, the authors show using Drosophila, that tumours exploit extracellular proline in response to muscle wasting, indicating that tumours induce muscle wasting as a nutrient-scavenging programme to drive tumourigenesis.
url	https://doi.org/10.1038/s41467-020-18502-9
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Systemic muscle wasting and coordinated tumour response drive tumourigenesis

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