Effect of remote ischemic postconditioning in inflammatory changes of the lung parenchyma of rats submitted to ischemia and reperfusion

• Main Authors: Rafael Cantero Dorsa, José Carlos Dorsa Vieira Pontes, Andréia Conceição Brochado Antoniolli, Guilherme Viotto Rodrigues da Silva, Ricardo Adala Benfatti, Carlos Henrique Marques dos Santos, Elenir Rose Cury Pontes, José Anderson Souza Goldiano
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Cirurgia Cardiovascular 2015-09-01
• Series: Brazilian Journal of Cardiovascular Surgery
• Subjects: Isquemia; Reperfusão; Pós-Condicionamento Isquêmico; Lesão Pulmonar
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382015000300011&lng=en&tlng=en
• ISSN: 1678-9741

AbstractObjective:To assess the effects of postconditioning remote in ischemia-reperfusion injury in rat lungs.Methods:Wistar rats (n=24) divided into 3 groups: GA (I/R) n=8, GB (R-Po) n=8, CG (control) n=8, underwent ischemia for 30 minutes artery occlusion abdominal aorta, followed by reperfusion for 60 minutes. Resected lungs and performed histological analysis and classification of morphological findings in accordance with the degree of tissue injury. Statistical analysis of the mean rating of the degree of tissue injury.Results:GA (3.6), GB (1.3) and CG (1.0). (GA GB X P<0.05).Conclusion:The remote postconditioning was able to minimize the inflammatory lesion of the lung parenchyma of rats undergoing ischemia and reperfusion process.