Intra-Tumoral Genomic Heterogeneity in Rectal Cancer: Mutational Status Is Dependent on Preoperative Biopsy Depth and Location

Intra-Tumoral Genomic Heterogeneity in Rectal Cancer: Mutational Status Is Dependent on Preoperative Biopsy Depth and Location

Neoadjuvant therapy before surgical resection is indicated for patients with locally advanced rectal cancer. However, a significant number of patients show minimal or no response to neoadjuvant therapy. Unfortunately, we are currently unable to predict response and identify non-responding patients b...

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Bibliographic Details
Main Authors: Floris A. Vuijk, Carlijn van de Water, Shannon Lent-van Vliet, Maxime J. M. van der Valk, Femke Simmer, Cornelis J. H. van de Velde, Alexander L. Vahrmeijer, Iris D. Nagtegaal, Denise E. Hilling
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
rectal cancer
intra-tumor heterogeneity
next generation sequencing
Online Access:https://www.mdpi.com/2072-6694/13/9/2271

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