Protein disulfide-isomerase interacts with a substrate protein at all stages along its folding pathway.

Protein disulfide-isomerase interacts with a substrate protein at all stages along its folding pathway.

In contrast to molecular chaperones that couple protein folding to ATP hydrolysis, protein disulfide-isomerase (PDI) catalyzes protein folding coupled to formation of disulfide bonds (oxidative folding). However, we do not know how PDI distinguishes folded, partly-folded and unfolded protein substra...

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Bibliographic Details
Main Authors: Alistair G Irvine, A Katrine Wallis, Narinder Sanghera, Michelle L Rowe, Lloyd W Ruddock, Mark J Howard, Richard A Williamson, Claudia A Blindauer, Robert B Freedman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3896340?pdf=render

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