Pathogen-induced proapoptotic phenotype and high CD95 (Fas) expression accompany a suboptimal CD8+ T-cell response: reversal by adenoviral vaccine.

Pathogen-induced proapoptotic phenotype and high CD95 (Fas) expression accompany a suboptimal CD8+ T-cell response: reversal by adenoviral vaccine.

MHC class Ia-restricted CD8(+) T cells are important mediators of the adaptive immune response against infections caused by intracellular microorganisms. Whereas antigen-specific effector CD8(+) T cells can clear infection caused by intracellular pathogens, in some circumstances, the immune response...

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Bibliographic Details
Main Authors: José Ronnie Vasconcelos, Oscar Bruña-Romero, Adriano F Araújo, Mariana R Dominguez, Jonatan Ersching, Bruna C G de Alencar, Alexandre V Machado, Ricardo T Gazzinelli, Karina R Bortoluci, Gustavo P Amarante-Mendes, Marcela F Lopes, Mauricio M Rodrigues
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3355083?pdf=render

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