Functional Roles and Therapeutic Applications of Exosomes in Hepatocellular Carcinoma

Functional Roles and Therapeutic Applications of Exosomes in Hepatocellular Carcinoma

Exosomes are important in intercellular communication. They assure the horizontal transfer of specific functional contents (i.e., proteins, lipids, RNA molecules, and circulating DNA) from donor to recipient cells. Notably, tumor-derived exosomes (TDEs) appear to be an important vehicle of specific...

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Main Authors: Laura Santangelo, Cecilia Battistelli, Claudia Montaldo, Franca Citarella, Raffaele Strippoli, Carla Cicchini
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2017/2931813
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spelling doaj-0e3eebdc126a48edac3c03cb253049112020-11-24T22:16:59ZengHindawi LimitedBioMed Research International2314-61332314-61412017-01-01201710.1155/2017/29318132931813Functional Roles and Therapeutic Applications of Exosomes in Hepatocellular CarcinomaLaura Santangelo0Cecilia Battistelli1Claudia Montaldo2Franca Citarella3Raffaele Strippoli4Carla Cicchini5National Institute for Infectious Diseases L. Spallanzani, IRCCS, Rome, ItalyIstituto Pasteur-Fondazione Cenci Bolognetti, Department of Cellular Biotechnologies and Haematology, Sapienza University of Rome, Rome, ItalyNational Institute for Infectious Diseases L. Spallanzani, IRCCS, Rome, ItalyIstituto Pasteur-Fondazione Cenci Bolognetti, Department of Cellular Biotechnologies and Haematology, Sapienza University of Rome, Rome, ItalyIstituto Pasteur-Fondazione Cenci Bolognetti, Department of Cellular Biotechnologies and Haematology, Sapienza University of Rome, Rome, ItalyIstituto Pasteur-Fondazione Cenci Bolognetti, Department of Cellular Biotechnologies and Haematology, Sapienza University of Rome, Rome, ItalyExosomes are important in intercellular communication. They assure the horizontal transfer of specific functional contents (i.e., proteins, lipids, RNA molecules, and circulating DNA) from donor to recipient cells. Notably, tumor-derived exosomes (TDEs) appear to be an important vehicle of specific signals in cancer, impacting on tumor growth and metastasis. Recent researches point to the characterization of exosomes in Hepatocellular Carcinoma (HCC), the major adult liver malignancy. In this review, we summarize current findings on HCC exosomes, focusing on the identification of noncoding RNAs as exosome-enriched functional regulators and new potential biomarkers. The great potential of exosomes in future HCC diagnostic and therapeutic approaches is underlined.http://dx.doi.org/10.1155/2017/2931813
collection DOAJ
language English
format Article
sources DOAJ
author Laura Santangelo
Cecilia Battistelli
Claudia Montaldo
Franca Citarella
Raffaele Strippoli
Carla Cicchini
spellingShingle Laura Santangelo
Cecilia Battistelli
Claudia Montaldo
Franca Citarella
Raffaele Strippoli
Carla Cicchini
Functional Roles and Therapeutic Applications of Exosomes in Hepatocellular Carcinoma
BioMed Research International
author_facet Laura Santangelo
Cecilia Battistelli
Claudia Montaldo
Franca Citarella
Raffaele Strippoli
Carla Cicchini
author_sort Laura Santangelo
title Functional Roles and Therapeutic Applications of Exosomes in Hepatocellular Carcinoma
title_short Functional Roles and Therapeutic Applications of Exosomes in Hepatocellular Carcinoma
title_full Functional Roles and Therapeutic Applications of Exosomes in Hepatocellular Carcinoma
title_fullStr Functional Roles and Therapeutic Applications of Exosomes in Hepatocellular Carcinoma
title_full_unstemmed Functional Roles and Therapeutic Applications of Exosomes in Hepatocellular Carcinoma
title_sort functional roles and therapeutic applications of exosomes in hepatocellular carcinoma
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2017-01-01
description Exosomes are important in intercellular communication. They assure the horizontal transfer of specific functional contents (i.e., proteins, lipids, RNA molecules, and circulating DNA) from donor to recipient cells. Notably, tumor-derived exosomes (TDEs) appear to be an important vehicle of specific signals in cancer, impacting on tumor growth and metastasis. Recent researches point to the characterization of exosomes in Hepatocellular Carcinoma (HCC), the major adult liver malignancy. In this review, we summarize current findings on HCC exosomes, focusing on the identification of noncoding RNAs as exosome-enriched functional regulators and new potential biomarkers. The great potential of exosomes in future HCC diagnostic and therapeutic approaches is underlined.
url http://dx.doi.org/10.1155/2017/2931813
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