Effects of propofol combined with different types of opioids on inflammatory stress response in painless gastroscopy
Objective: To study the effects of propofol combined with different types of opioids on inflammatory stress response in painless gastroscopy. Methods: Patients who underwent painless gastroscopy in our hospital between August 2014 and January 2018 were retrospectively analyzed, divided into those...
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doaj-0e40d7f8ae024bbbbc1abad506aa228e2020-11-24T20:44:37ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372018-06-0124063741Effects of propofol combined with different types of opioids on inflammatory stress response in painless gastroscopyTangnuer·Arken0Anesthesiology Department, Kashgar Prefecture First People’s Hospital in Xinjiang, Kashgar, Xinjiang, 844000Objective: To study the effects of propofol combined with different types of opioids on inflammatory stress response in painless gastroscopy. Methods: Patients who underwent painless gastroscopy in our hospital between August 2014 and January 2018 were retrospectively analyzed, divided into those with nalbuphine hydrochloride, dezocine and sufentanil according to different choice of opioids and included in group A, group B and group C of the study respectively. The contents of inflammatory cytokines and oxidative stress products in serum as well as the expression levels of inflammatory pathway molecules and antioxidant pathway molecules in peripheral blood were measured before and 6 h after gastroscopy. Results: HMGB-1, TNF-α, IFN-γ, CRP, MDA, OH- and O2- contents in serum as well as RhoA, ROCK, Wnt3a, β-catenin, JNK, ERK1/2, Nrf2, ARE, HO-1, γ-GCS and Prx1 expression in peripheral blood of three groups of patients after gastroscopy were higher than those before gastroscopy, and HMGB-1, TNF-α, IFN-γ, CRP, MDA, OH- and O2- contents in serum as well as RhoA, ROCK, Wnt3a, β-catenin, JNK and ERK1/2 expression in peripheral blood of group A after gastroscopy were lower than those of group B and group C whereas Nrf2, ARE, HO-1, γ-GCS and Prx1 expression in peripheral blood were higher than those of group B and group C. Conclusion: Propofol combined with nalbuphine hydrochloride can be more effective than dezocine and sufentanil to reduce the inflammatory stress response in painless gastroscopy.http://www.hnykdxxb.com/PDF/201806/10.pdf Painless gastroscopyPropofolOpioidsInflammatory responseStress response |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tangnuer·Arken |
spellingShingle |
Tangnuer·Arken Effects of propofol combined with different types of opioids on inflammatory stress response in painless gastroscopy Journal of Hainan Medical University Painless gastroscopy Propofol Opioids Inflammatory response Stress response |
author_facet |
Tangnuer·Arken |
author_sort |
Tangnuer·Arken |
title |
Effects of propofol combined with different types of opioids on inflammatory stress response in painless gastroscopy |
title_short |
Effects of propofol combined with different types of opioids on inflammatory stress response in painless gastroscopy |
title_full |
Effects of propofol combined with different types of opioids on inflammatory stress response in painless gastroscopy |
title_fullStr |
Effects of propofol combined with different types of opioids on inflammatory stress response in painless gastroscopy |
title_full_unstemmed |
Effects of propofol combined with different types of opioids on inflammatory stress response in painless gastroscopy |
title_sort |
effects of propofol combined with different types of opioids on inflammatory stress response in painless gastroscopy |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2018-06-01 |
description |
Objective: To study the effects of propofol combined with different types of opioids on
inflammatory stress response in painless gastroscopy. Methods: Patients who underwent
painless gastroscopy in our hospital between August 2014 and January 2018 were
retrospectively analyzed, divided into those with nalbuphine hydrochloride, dezocine and
sufentanil according to different choice of opioids and included in group A, group B and
group C of the study respectively. The contents of inflammatory cytokines and oxidative
stress products in serum as well as the expression levels of inflammatory pathway molecules
and antioxidant pathway molecules in peripheral blood were measured before and 6 h after
gastroscopy. Results: HMGB-1, TNF-α, IFN-γ, CRP, MDA, OH- and O2- contents in
serum as well as RhoA, ROCK, Wnt3a, β-catenin, JNK, ERK1/2, Nrf2, ARE, HO-1, γ-GCS
and Prx1 expression in peripheral blood of three groups of patients after gastroscopy were
higher than those before gastroscopy, and HMGB-1, TNF-α, IFN-γ, CRP, MDA, OH-
and O2- contents in serum as well as RhoA, ROCK, Wnt3a, β-catenin, JNK and ERK1/2
expression in peripheral blood of group A after gastroscopy were lower than those of group B
and group C whereas Nrf2, ARE, HO-1, γ-GCS and Prx1 expression in peripheral blood were
higher than those of group B and group C. Conclusion: Propofol combined with nalbuphine
hydrochloride can be more effective than dezocine and sufentanil to reduce the inflammatory
stress response in painless gastroscopy. |
topic |
Painless gastroscopy Propofol Opioids Inflammatory response Stress response |
url |
http://www.hnykdxxb.com/PDF/201806/10.pdf |
work_keys_str_mv |
AT tangnuerarken effectsofpropofolcombinedwithdifferenttypesofopioidsoninflammatorystressresponseinpainlessgastroscopy |
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1716816818560040960 |