Role of dietary curcumin against waterborne lead toxicity in common carp Cyprinus carpio
Curcumin exhibited numerous key activities including antioxidant, anti-inflammatory, and immunostimulatory effects in fish. This study evaluated the protective effects of curcumin (CUR) against lead (Pb)-induced toxicities in fish. Healthy Cyprinus carpio L. individuals were segregated into control,...
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2021-08-01
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doaj-0e4385e5fec54489b25cf3fad4c746152021-06-03T14:44:43ZengElsevierEcotoxicology and Environmental Safety0147-65132021-08-01219112318Role of dietary curcumin against waterborne lead toxicity in common carp Cyprinus carpioSib Sankar Giri0Min Jung Kim1Sang Guen Kim2Sang Wha Kim3Jeong Woo Kang4Jun Kwon5Sung Bin Lee6Won Joon Jung7Venkatachalam Sukumaran8Se Chang Park9Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, South KoreaDepartment of Research and Development, Mjbiogen corp., Seoul 04788, South KoreaLaboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, South KoreaLaboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, South KoreaLaboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, South KoreaLaboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, South KoreaLaboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, South KoreaLaboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, South KoreaDept. of Zoology, Kundavai Nachiyar Government Arts College for Women (Autonomous), Thanjavur 613007, Tamil Nadu, IndiaLaboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, South Korea; Corresponding author.Curcumin exhibited numerous key activities including antioxidant, anti-inflammatory, and immunostimulatory effects in fish. This study evaluated the protective effects of curcumin (CUR) against lead (Pb)-induced toxicities in fish. Healthy Cyprinus carpio L. individuals were segregated into control, Pb only, Pb+CUR, and CUR only groups. Pb groups were exposed to 1 mg L −1 of Pb, and CUR groups were fed a basal diet supplemented with 15 g kg−1 of CUR. After eight weeks, growth performance, Pb accumulation in tissues, various haemato-biochemical parameters, immune responses, and cytokine gene expression were measured. Dietary CUR effectively decreased Pb accumulation in tissues and increased the survival of Pb-exposed fish. Co-treatment with Pb and CUR reversed alterations in haemato-biochemical parameters, ameliorated Pb-induced oxidative stress, enhanced immune responses, and restored intestinal enzymatic activities. Dietary CUR reversed changes in intestinal microbiota in Pb-exposed fish. Pb-induced upregulation of NF-κBp65 and HSP70 was inhibited by dietary CUR. CUR supplementation upregulated the mRNA levels of SOD, Nrf2, IL-10, and CYP450 1A and attenuated Pb-induced degradation of I κB-α mRNA levels. Overall, CUR antagonizes Pb-induced negative impacts in fish. Thus, dietary CUR had several beneficial effects on immune responses, decreased Pb accumulation in tissues, and reversed Pb-induced oxidative stress in fish. Therefore, CUR plays a protective role in Pb-induced immune toxicity in fish, and, as such, may be suitable as an aqua feed additive for use in carp aquaculture.http://www.sciencedirect.com/science/article/pii/S0147651321004292Heavy metalOxidative stressGene expressionHepatotoxicityAntioxidant enzymesHepatosomatic index |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sib Sankar Giri Min Jung Kim Sang Guen Kim Sang Wha Kim Jeong Woo Kang Jun Kwon Sung Bin Lee Won Joon Jung Venkatachalam Sukumaran Se Chang Park |
spellingShingle |
Sib Sankar Giri Min Jung Kim Sang Guen Kim Sang Wha Kim Jeong Woo Kang Jun Kwon Sung Bin Lee Won Joon Jung Venkatachalam Sukumaran Se Chang Park Role of dietary curcumin against waterborne lead toxicity in common carp Cyprinus carpio Ecotoxicology and Environmental Safety Heavy metal Oxidative stress Gene expression Hepatotoxicity Antioxidant enzymes Hepatosomatic index |
author_facet |
Sib Sankar Giri Min Jung Kim Sang Guen Kim Sang Wha Kim Jeong Woo Kang Jun Kwon Sung Bin Lee Won Joon Jung Venkatachalam Sukumaran Se Chang Park |
author_sort |
Sib Sankar Giri |
title |
Role of dietary curcumin against waterborne lead toxicity in common carp Cyprinus carpio |
title_short |
Role of dietary curcumin against waterborne lead toxicity in common carp Cyprinus carpio |
title_full |
Role of dietary curcumin against waterborne lead toxicity in common carp Cyprinus carpio |
title_fullStr |
Role of dietary curcumin against waterborne lead toxicity in common carp Cyprinus carpio |
title_full_unstemmed |
Role of dietary curcumin against waterborne lead toxicity in common carp Cyprinus carpio |
title_sort |
role of dietary curcumin against waterborne lead toxicity in common carp cyprinus carpio |
publisher |
Elsevier |
series |
Ecotoxicology and Environmental Safety |
issn |
0147-6513 |
publishDate |
2021-08-01 |
description |
Curcumin exhibited numerous key activities including antioxidant, anti-inflammatory, and immunostimulatory effects in fish. This study evaluated the protective effects of curcumin (CUR) against lead (Pb)-induced toxicities in fish. Healthy Cyprinus carpio L. individuals were segregated into control, Pb only, Pb+CUR, and CUR only groups. Pb groups were exposed to 1 mg L −1 of Pb, and CUR groups were fed a basal diet supplemented with 15 g kg−1 of CUR. After eight weeks, growth performance, Pb accumulation in tissues, various haemato-biochemical parameters, immune responses, and cytokine gene expression were measured. Dietary CUR effectively decreased Pb accumulation in tissues and increased the survival of Pb-exposed fish. Co-treatment with Pb and CUR reversed alterations in haemato-biochemical parameters, ameliorated Pb-induced oxidative stress, enhanced immune responses, and restored intestinal enzymatic activities. Dietary CUR reversed changes in intestinal microbiota in Pb-exposed fish. Pb-induced upregulation of NF-κBp65 and HSP70 was inhibited by dietary CUR. CUR supplementation upregulated the mRNA levels of SOD, Nrf2, IL-10, and CYP450 1A and attenuated Pb-induced degradation of I κB-α mRNA levels. Overall, CUR antagonizes Pb-induced negative impacts in fish. Thus, dietary CUR had several beneficial effects on immune responses, decreased Pb accumulation in tissues, and reversed Pb-induced oxidative stress in fish. Therefore, CUR plays a protective role in Pb-induced immune toxicity in fish, and, as such, may be suitable as an aqua feed additive for use in carp aquaculture. |
topic |
Heavy metal Oxidative stress Gene expression Hepatotoxicity Antioxidant enzymes Hepatosomatic index |
url |
http://www.sciencedirect.com/science/article/pii/S0147651321004292 |
work_keys_str_mv |
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