Diffusivity and quantitative T1 profile of human visual white matter tracts after retinal ganglion cell damage
In patients with retinal ganglion cell diseases, recent diffusion tensor imaging (DTI) studies have revealed structural abnormalities in visual white matter tracts such as the optic tract, and optic radiation. However, the microstructural origin of these diffusivity changes is unknown as DTI metrics...
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doaj-0e446bdafb2649d68311be75a4638e662020-11-25T01:51:04ZengElsevierNeuroImage: Clinical2213-15822019-01-0123Diffusivity and quantitative T1 profile of human visual white matter tracts after retinal ganglion cell damageHiromasa Takemura0Shumpei Ogawa1Aviv A. Mezer2Hiroshi Horiguchi3Atsushi Miyazaki4Kenji Matsumoto5Keigo Shikishima6Tadashi Nakano7Yoichiro Masuda8Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology, and Osaka University, Suita, Japan; Graduate School of Frontier Biosciences, Osaka University, Suita, Japan; Correspondence to: H. Takemura, Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology, and Osaka University, 1-4 Yamadaoka, Suita-shi, Osaka 565-0871, Japan.Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan; Department of Ophthalmology, Atsugi city hospital, Atsugi, Japan; Correspondence to: S. Ogawa, Department of Ophthalmology, The Jikei University School of Medicine, 3-19-18 Nishi-shinbashi, Minato-ku, Tokyo 105-8471, Japan.The Edmond and Lily Safra Center for Brain Science, The Hebrew University of Jerusalem, IsraelDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, JapanBrain Science Institute, Tamagawa University, Machida, JapanBrain Science Institute, Tamagawa University, Machida, JapanDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, JapanDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, JapanDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, JapanIn patients with retinal ganglion cell diseases, recent diffusion tensor imaging (DTI) studies have revealed structural abnormalities in visual white matter tracts such as the optic tract, and optic radiation. However, the microstructural origin of these diffusivity changes is unknown as DTI metrics involve multiple biological factors and do not correlate directly with specific microstructural properties. In contrast, recent quantitative T1 (qT1) mapping methods provide tissue property measurements relatively specific to myelin volume fractions in white matter. This study aims to improve our understanding of microstructural changes in visual white matter tracts following retinal ganglion cell damage in Leber's hereditary optic neuropathy (LHON) patients by combining DTI and qT1 measurements. We collected these measurements from seven LHON patients and twenty age-matched control subjects. For all individuals, we identified the optic tract and the optic radiation using probabilistic tractography, and evaluated diffusivity and qT1 profiles along them. Both diffusivity and qT1 measurements in the optic tract differed significantly between LHON patients and controls. In the optic radiation, these changes were observed in diffusivity but were not evident in qT1 measurements. This suggests that myelin loss may not explain trans-synaptic diffusivity changes in the optic radiation as a consequence of retinal ganglion cell disease. Keywords: Leber's hereditary optic neuropathy, Optic radiation, Optic tract, White matter, Myelin, MRIhttp://www.sciencedirect.com/science/article/pii/S2213158219301767 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hiromasa Takemura Shumpei Ogawa Aviv A. Mezer Hiroshi Horiguchi Atsushi Miyazaki Kenji Matsumoto Keigo Shikishima Tadashi Nakano Yoichiro Masuda |
spellingShingle |
Hiromasa Takemura Shumpei Ogawa Aviv A. Mezer Hiroshi Horiguchi Atsushi Miyazaki Kenji Matsumoto Keigo Shikishima Tadashi Nakano Yoichiro Masuda Diffusivity and quantitative T1 profile of human visual white matter tracts after retinal ganglion cell damage NeuroImage: Clinical |
author_facet |
Hiromasa Takemura Shumpei Ogawa Aviv A. Mezer Hiroshi Horiguchi Atsushi Miyazaki Kenji Matsumoto Keigo Shikishima Tadashi Nakano Yoichiro Masuda |
author_sort |
Hiromasa Takemura |
title |
Diffusivity and quantitative T1 profile of human visual white matter tracts after retinal ganglion cell damage |
title_short |
Diffusivity and quantitative T1 profile of human visual white matter tracts after retinal ganglion cell damage |
title_full |
Diffusivity and quantitative T1 profile of human visual white matter tracts after retinal ganglion cell damage |
title_fullStr |
Diffusivity and quantitative T1 profile of human visual white matter tracts after retinal ganglion cell damage |
title_full_unstemmed |
Diffusivity and quantitative T1 profile of human visual white matter tracts after retinal ganglion cell damage |
title_sort |
diffusivity and quantitative t1 profile of human visual white matter tracts after retinal ganglion cell damage |
publisher |
Elsevier |
series |
NeuroImage: Clinical |
issn |
2213-1582 |
publishDate |
2019-01-01 |
description |
In patients with retinal ganglion cell diseases, recent diffusion tensor imaging (DTI) studies have revealed structural abnormalities in visual white matter tracts such as the optic tract, and optic radiation. However, the microstructural origin of these diffusivity changes is unknown as DTI metrics involve multiple biological factors and do not correlate directly with specific microstructural properties. In contrast, recent quantitative T1 (qT1) mapping methods provide tissue property measurements relatively specific to myelin volume fractions in white matter. This study aims to improve our understanding of microstructural changes in visual white matter tracts following retinal ganglion cell damage in Leber's hereditary optic neuropathy (LHON) patients by combining DTI and qT1 measurements. We collected these measurements from seven LHON patients and twenty age-matched control subjects. For all individuals, we identified the optic tract and the optic radiation using probabilistic tractography, and evaluated diffusivity and qT1 profiles along them. Both diffusivity and qT1 measurements in the optic tract differed significantly between LHON patients and controls. In the optic radiation, these changes were observed in diffusivity but were not evident in qT1 measurements. This suggests that myelin loss may not explain trans-synaptic diffusivity changes in the optic radiation as a consequence of retinal ganglion cell disease. Keywords: Leber's hereditary optic neuropathy, Optic radiation, Optic tract, White matter, Myelin, MRI |
url |
http://www.sciencedirect.com/science/article/pii/S2213158219301767 |
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