Serum vitamin D levels and ovarian reserve markers in secondary amenorrhea patients: Is there a link?
Objective To investigate whether serum 25-hydroxyvitamin D [25(OH)D] level is associated with ovarian reserve markers in secondary amenorrhea (SA) patients. Methods Sixty-three women diagnosed with SA were recruited during 12 months from the initiation of this prospective observational study. Serum...
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Korean Society of Obstetrics and Gynecology
2020-07-01
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doaj-0e605483fea64c5b9a0c84f746c2f6ee2020-11-25T02:36:56ZengKorean Society of Obstetrics and GynecologyObstetrics & Gynecology Science2287-85722287-85802020-07-0163452152810.5468/ogs.200718556Serum vitamin D levels and ovarian reserve markers in secondary amenorrhea patients: Is there a link?Gyung-Mee Kim0Gyun-Ho Jeon1 Department of Psychiatry, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea Department of Obstetrics and Gynecology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, KoreaObjective To investigate whether serum 25-hydroxyvitamin D [25(OH)D] level is associated with ovarian reserve markers in secondary amenorrhea (SA) patients. Methods Sixty-three women diagnosed with SA were recruited during 12 months from the initiation of this prospective observational study. Serum 25(OH)D levels, serum anti-Müllerian hormone (AMH) levels and antral follicle count (AFC) were estimated in study participants and ovarian reserve markers were compared between participants with vitamin D deficiency and those with normal vitamin D levels. Results Of the 63 participants, 27 (42.9%) were vitamin D deficient (<20 ng/mL) and 36 (57.1%) had normal vitamin D levels. The mean AMH levels and AFC were 10.86±8.94 µ/L and 15.23±7.65 in the vitamin D deficient group, and 7.24±5.62 µ/L and 12.30±6.95 in the normal vitamin D group. Univariate and multivariate linear regression analysis of log10 transformed AMH and AFC with serum 25(OH)D adjusted for age and body mass index confirmed no association between vitamin D levels and AMH levels or AFC. There was also no correlation between serum 25(OH)D and AMH levels or AFC in all participants. However, participants with vitamin D deficiency had an increased chance of having polycystic ovarian syndrome (PCOS) as cause of SA than those with normal vitamin D levels (adjusted odds ratio, 7.559; 95% confidence interval, 1.28–44.65; P=0.026) after adjustment for clinical factors by logistic regression model. Conclusion There was no correlation between serum 25(OH)D levels and ovarian reserve markers in SA patients, but vitamin D deficiency may be linked to PCOS patients.http://www.ogscience.org/upload/pdf/ogs-20071.pdfanti-mullerian hormoneamenorrheaovarian reserve25-hydroxyvitamin dpolycystic ovarian syndrome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gyung-Mee Kim Gyun-Ho Jeon |
spellingShingle |
Gyung-Mee Kim Gyun-Ho Jeon Serum vitamin D levels and ovarian reserve markers in secondary amenorrhea patients: Is there a link? Obstetrics & Gynecology Science anti-mullerian hormone amenorrhea ovarian reserve 25-hydroxyvitamin d polycystic ovarian syndrome |
author_facet |
Gyung-Mee Kim Gyun-Ho Jeon |
author_sort |
Gyung-Mee Kim |
title |
Serum vitamin D levels and ovarian reserve markers in secondary amenorrhea patients: Is there a link? |
title_short |
Serum vitamin D levels and ovarian reserve markers in secondary amenorrhea patients: Is there a link? |
title_full |
Serum vitamin D levels and ovarian reserve markers in secondary amenorrhea patients: Is there a link? |
title_fullStr |
Serum vitamin D levels and ovarian reserve markers in secondary amenorrhea patients: Is there a link? |
title_full_unstemmed |
Serum vitamin D levels and ovarian reserve markers in secondary amenorrhea patients: Is there a link? |
title_sort |
serum vitamin d levels and ovarian reserve markers in secondary amenorrhea patients: is there a link? |
publisher |
Korean Society of Obstetrics and Gynecology |
series |
Obstetrics & Gynecology Science |
issn |
2287-8572 2287-8580 |
publishDate |
2020-07-01 |
description |
Objective To investigate whether serum 25-hydroxyvitamin D [25(OH)D] level is associated with ovarian reserve markers in secondary amenorrhea (SA) patients. Methods Sixty-three women diagnosed with SA were recruited during 12 months from the initiation of this prospective observational study. Serum 25(OH)D levels, serum anti-Müllerian hormone (AMH) levels and antral follicle count (AFC) were estimated in study participants and ovarian reserve markers were compared between participants with vitamin D deficiency and those with normal vitamin D levels. Results Of the 63 participants, 27 (42.9%) were vitamin D deficient (<20 ng/mL) and 36 (57.1%) had normal vitamin D levels. The mean AMH levels and AFC were 10.86±8.94 µ/L and 15.23±7.65 in the vitamin D deficient group, and 7.24±5.62 µ/L and 12.30±6.95 in the normal vitamin D group. Univariate and multivariate linear regression analysis of log10 transformed AMH and AFC with serum 25(OH)D adjusted for age and body mass index confirmed no association between vitamin D levels and AMH levels or AFC. There was also no correlation between serum 25(OH)D and AMH levels or AFC in all participants. However, participants with vitamin D deficiency had an increased chance of having polycystic ovarian syndrome (PCOS) as cause of SA than those with normal vitamin D levels (adjusted odds ratio, 7.559; 95% confidence interval, 1.28–44.65; P=0.026) after adjustment for clinical factors by logistic regression model. Conclusion There was no correlation between serum 25(OH)D levels and ovarian reserve markers in SA patients, but vitamin D deficiency may be linked to PCOS patients. |
topic |
anti-mullerian hormone amenorrhea ovarian reserve 25-hydroxyvitamin d polycystic ovarian syndrome |
url |
http://www.ogscience.org/upload/pdf/ogs-20071.pdf |
work_keys_str_mv |
AT gyungmeekim serumvitamindlevelsandovarianreservemarkersinsecondaryamenorrheapatientsistherealink AT gyunhojeon serumvitamindlevelsandovarianreservemarkersinsecondaryamenorrheapatientsistherealink |
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