Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes
Pathogen triggered N-terminal degradation of NLRP1 and CARD8 by the proteasome releases their C-terminal UPA-CARD fragments (CT) to form the inflammasome, which in turn activates caspase-1. Here, the authors present the cryo-EM structures of the NLRP1-CT and CARD8-CT helical filaments as well as the...
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Bibliographic Details
Main Authors: |
L. Robert Hollingsworth,
Liron David,
Yang Li,
Andrew R. Griswold,
Jianbin Ruan,
Humayun Sharif,
Pietro Fontana,
Elizabeth L. Orth-He,
Tian-Min Fu,
Daniel A. Bachovchin,
Hao Wu |
Format: | Article
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Language: | English |
Published: |
Nature Publishing Group
2021-01-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-020-20320-y
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