Cholinergic Enhancement of Brain Activation in Mild Cognitive Impairment (MCI) during Episodic Memory Encoding

Cholinergic Enhancement of Brain Activation in Mild Cognitive Impairment (MCI) during Episodic Memory Encoding

Objective: To determine the physiological impact of treatment with donepezil (Aricept) on neural circuitry supporting episodic memory encoding in patients with amnestic mild cognitive impairment (MCI) using functional MRI (fMRI). Methods: 18 patients with MCI and 20 age-matched healthy controls (HC)...

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Bibliographic Details
Main Authors: Shannon L Risacher, Yang eWang, Heather A Wishart, Laura A Rabin, Laura A Flashman, Brenna C McDonald, John D West, Robert B Santulli, Andrew J Saykin
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Psychiatry
Subjects:
Mild Cognitive Impairment
functional magnetic resonance imaging (fMRI)
Alzheimer’s disease (AD)
episodic encoding
donepezil (Aricept)
task-related functional connectivity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00105/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00105/full

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