Endogenous modulators of neurotrophin signaling: Landscape of the transient ATP-NGF interactions

Endogenous modulators of neurotrophin signaling: Landscape of the transient ATP-NGF interactions

The Nerve Growth Factor (NGF) neurotrophin acts in the maintenance and growth of neuronal populations. Despite the detailed knowledge of NGF’s role in neuron physiology, the structural and mechanistic determinants of NGF bioactivity modulated by essential endogenous ligands are still lacking. We pre...

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Bibliographic Details
Main Authors: Francesca Paoletti, Franci Merzel, Alberto Cassetta, Iza Ogris, Sonia Covaceuszach, Jože Grdadolnik, Doriano Lamba, Simona Golič Grdadolnik
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Neurotrophins
Endogenous ligands
ATP modulation
TrkA, p75NTR receptors
NGF interactions
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021001902

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