Hepatitis B vaccination coverage in Germany: systematic review
Abstract Background Despite being considered as a low prevalence country for hepatitis B (HBV), some populations in Germany are at higher risk of infection. In the context of the World Health Organization’s (WHO) viral hepatitis elimination goals, a valid epidemiological data base is needed to plan...
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doaj-0e6ecf358a374028a2a932fed3661f982021-08-15T11:47:09ZengBMCBMC Infectious Diseases1471-23342021-08-0121111710.1186/s12879-021-06400-4Hepatitis B vaccination coverage in Germany: systematic reviewGyde Steffen0Ida Sperle1Thomas Harder2Navina Sarma3Sandra Beermann4Roma Thamm5Viviane Bremer6Ruth Zimmermann7Sandra Dudareva8Department of Infectious Disease Epidemiology, Unit for HIV/AIDS, STI and Blood-borne Infections, Robert Koch InstituteDepartment of Infectious Disease Epidemiology, Unit for Gastrointestinal Infections, Zoonoses and Tropical Infections, Robert Koch InstituteDepartment of Infectious Disease Epidemiology, Immunisation Unit, Robert Koch InstituteDepartment of Infectious Disease Epidemiology, Unit for Crisis Management, Outbreak Investigations and Training Programmes, Focal Point for the Public Health Service, Robert Koch InstituteCentre for International Health Protection, Robert Koch InstituteDepartment of Epidemiology and Health Monitoring, Unit for Physical Health, Robert Koch InstituteDepartment of Infectious Disease Epidemiology, Unit for HIV/AIDS, STI and Blood-borne Infections, Robert Koch InstituteDepartment of Infectious Disease Epidemiology, Unit for HIV/AIDS, STI and Blood-borne Infections, Robert Koch InstituteDepartment of Infectious Disease Epidemiology, Unit for HIV/AIDS, STI and Blood-borne Infections, Robert Koch InstituteAbstract Background Despite being considered as a low prevalence country for hepatitis B (HBV), some populations in Germany are at higher risk of infection. In the context of the World Health Organization’s (WHO) viral hepatitis elimination goals, a valid epidemiological data base is needed to plan and monitor the national response. Prevention strategies include general and targeted HBV vaccination programmes. Objective The aim of this work was to estimate the HBV vaccination coverage (VC) in the general population (GP) and different population groups in Germany from available evidence and to identify current evidence gaps for future research. Methods We conducted a systematic review on HBV VC in the general population and populations at high risk of HBV exposure or severe infection in Germany. We included eligible publications (01/01/2017 to 06/06/2020) from databases Embase, Pubmed and Livivo, from a previous scoping review (including data published 01/01/2005–17/03/2017), from the national surveillance system and screened the reference lists of all publications at full text level. Risk of bias was assessed using the Hoy et al. tool. Results We included 68 publications of 67 studies and assigned them to one or more suitable population groups. Twenty-one studies contained data among children/adolescents and three among adults from the GP (VC 65.8–90.5% and 22.9–52.1%, respectively), one among travelers (VC 89.0%), 13 among immunocompromised populations (VC 7.8–89.0%), 16 among populations with occupational risk and 16 with non-occupational risk of HBV exposure (VC 63.6–96.5% and 4.4–84.5%, respectively). Conclusion Comprehensive evidence at low risk of bias was identified for children/adolescents. However, 25 years after including HBV in the national immunisation schedule, VC in Germany is still below the 95%-goal defined by WHO. For people at occupational risk of HBV exposure, VC was mostly reported to be over the WHO goal of 80%, but quality of evidence was heterogenous and should be improved. For people at non-occupational risk of HBV exposure, evidence was sparse and of low quality. The low VC highlights the need for future research to plan vaccination programmes targeting these populations.https://doi.org/10.1186/s12879-021-06400-4Hepatitis BVaccination coverageGermanyPopulations at riskSystematic review |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gyde Steffen Ida Sperle Thomas Harder Navina Sarma Sandra Beermann Roma Thamm Viviane Bremer Ruth Zimmermann Sandra Dudareva |
spellingShingle |
Gyde Steffen Ida Sperle Thomas Harder Navina Sarma Sandra Beermann Roma Thamm Viviane Bremer Ruth Zimmermann Sandra Dudareva Hepatitis B vaccination coverage in Germany: systematic review BMC Infectious Diseases Hepatitis B Vaccination coverage Germany Populations at risk Systematic review |
author_facet |
Gyde Steffen Ida Sperle Thomas Harder Navina Sarma Sandra Beermann Roma Thamm Viviane Bremer Ruth Zimmermann Sandra Dudareva |
author_sort |
Gyde Steffen |
title |
Hepatitis B vaccination coverage in Germany: systematic review |
title_short |
Hepatitis B vaccination coverage in Germany: systematic review |
title_full |
Hepatitis B vaccination coverage in Germany: systematic review |
title_fullStr |
Hepatitis B vaccination coverage in Germany: systematic review |
title_full_unstemmed |
Hepatitis B vaccination coverage in Germany: systematic review |
title_sort |
hepatitis b vaccination coverage in germany: systematic review |
publisher |
BMC |
series |
BMC Infectious Diseases |
issn |
1471-2334 |
publishDate |
2021-08-01 |
description |
Abstract Background Despite being considered as a low prevalence country for hepatitis B (HBV), some populations in Germany are at higher risk of infection. In the context of the World Health Organization’s (WHO) viral hepatitis elimination goals, a valid epidemiological data base is needed to plan and monitor the national response. Prevention strategies include general and targeted HBV vaccination programmes. Objective The aim of this work was to estimate the HBV vaccination coverage (VC) in the general population (GP) and different population groups in Germany from available evidence and to identify current evidence gaps for future research. Methods We conducted a systematic review on HBV VC in the general population and populations at high risk of HBV exposure or severe infection in Germany. We included eligible publications (01/01/2017 to 06/06/2020) from databases Embase, Pubmed and Livivo, from a previous scoping review (including data published 01/01/2005–17/03/2017), from the national surveillance system and screened the reference lists of all publications at full text level. Risk of bias was assessed using the Hoy et al. tool. Results We included 68 publications of 67 studies and assigned them to one or more suitable population groups. Twenty-one studies contained data among children/adolescents and three among adults from the GP (VC 65.8–90.5% and 22.9–52.1%, respectively), one among travelers (VC 89.0%), 13 among immunocompromised populations (VC 7.8–89.0%), 16 among populations with occupational risk and 16 with non-occupational risk of HBV exposure (VC 63.6–96.5% and 4.4–84.5%, respectively). Conclusion Comprehensive evidence at low risk of bias was identified for children/adolescents. However, 25 years after including HBV in the national immunisation schedule, VC in Germany is still below the 95%-goal defined by WHO. For people at occupational risk of HBV exposure, VC was mostly reported to be over the WHO goal of 80%, but quality of evidence was heterogenous and should be improved. For people at non-occupational risk of HBV exposure, evidence was sparse and of low quality. The low VC highlights the need for future research to plan vaccination programmes targeting these populations. |
topic |
Hepatitis B Vaccination coverage Germany Populations at risk Systematic review |
url |
https://doi.org/10.1186/s12879-021-06400-4 |
work_keys_str_mv |
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