SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells

SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells

Tight regulation of retrotransposons such as endogenous retroviruses (ERVs) is essential for genome and transcriptome integrity. Here, the authors show that the ATPase function of the chromatin remodeler SMARCAD1 facilitates the binding of KAP1 to ERVs and is required for their repression in embryon...

Full description

Bibliographic Details
Main Authors: Parysatis Sachs, Dong Ding, Philipp Bergmaier, Boris Lamp, Christina Schlagheck, Florian Finkernagel, Andrea Nist, Thorsten Stiewe, Jacqueline E. Mermoud
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09078-0
id doaj-0e710344df08499391e740770a34e858
record_format Article
spelling doaj-0e710344df08499391e740770a34e8582021-05-11T12:20:37ZengNature Publishing GroupNature Communications2041-17232019-03-0110111610.1038/s41467-019-09078-0SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cellsParysatis Sachs0Dong Ding1Philipp Bergmaier2Boris Lamp3Christina Schlagheck4Florian Finkernagel5Andrea Nist6Thorsten Stiewe7Jacqueline E. Mermoud8Institute of Molecular Biology and Tumour Research, Philipps University MarburgInstitute of Molecular Biology and Tumour Research, Philipps University MarburgInstitute of Molecular Biology and Tumour Research, Philipps University MarburgInstitute of Molecular Oncology, Genomics Core Facility, Philipps University MarburgInstitute of Molecular Biology and Tumour Research, Philipps University MarburgInstitute of Molecular Biology and Tumour Research, Center for Tumor Biology and Immunology, Philipps University MarburgInstitute of Molecular Oncology, Genomics Core Facility, Philipps University MarburgInstitute of Molecular Oncology, Genomics Core Facility, Philipps University MarburgInstitute of Molecular Biology and Tumour Research, Philipps University MarburgTight regulation of retrotransposons such as endogenous retroviruses (ERVs) is essential for genome and transcriptome integrity. Here, the authors show that the ATPase function of the chromatin remodeler SMARCAD1 facilitates the binding of KAP1 to ERVs and is required for their repression in embryonic stem cells.https://doi.org/10.1038/s41467-019-09078-0
collection DOAJ
language English
format Article
sources DOAJ
author Parysatis Sachs
Dong Ding
Philipp Bergmaier
Boris Lamp
Christina Schlagheck
Florian Finkernagel
Andrea Nist
Thorsten Stiewe
Jacqueline E. Mermoud
spellingShingle Parysatis Sachs
Dong Ding
Philipp Bergmaier
Boris Lamp
Christina Schlagheck
Florian Finkernagel
Andrea Nist
Thorsten Stiewe
Jacqueline E. Mermoud
SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells
Nature Communications
author_facet Parysatis Sachs
Dong Ding
Philipp Bergmaier
Boris Lamp
Christina Schlagheck
Florian Finkernagel
Andrea Nist
Thorsten Stiewe
Jacqueline E. Mermoud
author_sort Parysatis Sachs
title SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells
title_short SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells
title_full SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells
title_fullStr SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells
title_full_unstemmed SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells
title_sort smarcad1 atpase activity is required to silence endogenous retroviruses in embryonic stem cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-03-01
description Tight regulation of retrotransposons such as endogenous retroviruses (ERVs) is essential for genome and transcriptome integrity. Here, the authors show that the ATPase function of the chromatin remodeler SMARCAD1 facilitates the binding of KAP1 to ERVs and is required for their repression in embryonic stem cells.
url https://doi.org/10.1038/s41467-019-09078-0
work_keys_str_mv AT parysatissachs smarcad1atpaseactivityisrequiredtosilenceendogenousretrovirusesinembryonicstemcells
AT dongding smarcad1atpaseactivityisrequiredtosilenceendogenousretrovirusesinembryonicstemcells
AT philippbergmaier smarcad1atpaseactivityisrequiredtosilenceendogenousretrovirusesinembryonicstemcells
AT borislamp smarcad1atpaseactivityisrequiredtosilenceendogenousretrovirusesinembryonicstemcells
AT christinaschlagheck smarcad1atpaseactivityisrequiredtosilenceendogenousretrovirusesinembryonicstemcells
AT florianfinkernagel smarcad1atpaseactivityisrequiredtosilenceendogenousretrovirusesinembryonicstemcells
AT andreanist smarcad1atpaseactivityisrequiredtosilenceendogenousretrovirusesinembryonicstemcells
AT thorstenstiewe smarcad1atpaseactivityisrequiredtosilenceendogenousretrovirusesinembryonicstemcells
AT jacquelineemermoud smarcad1atpaseactivityisrequiredtosilenceendogenousretrovirusesinembryonicstemcells
_version_ 1721445003806375936

Similar Items