A Cholera Conjugate Vaccine Containing O-specific Polysaccharide (OSP) of V. cholerae O1 Inaba and Recombinant Fragment of Tetanus Toxin Heavy Chain (OSP:rTTHc) Induces Serum, Memory and Lamina Proprial Responses against OSP and Is Protective in Mice.

A Cholera Conjugate Vaccine Containing O-specific Polysaccharide (OSP) of V. cholerae O1 Inaba and Recombinant Fragment of Tetanus Toxin Heavy Chain (OSP:rTTHc) Induces Serum, Memory and Lamina Proprial Responses against OSP and Is Protective in Mice.

BACKGROUND:Vibrio cholerae is the cause of cholera, a severe watery diarrhea. Protection against cholera is serogroup specific. Serogroup specificity is defined by the O-specific polysaccharide (OSP) component of lipopolysaccharide (LPS). METHODOLOGY:Here we describe a conjugate vaccine for cholera...

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Bibliographic Details
Main Authors: Md Abu Sayeed, Meagan Kelly Bufano, Peng Xu, Grace Eckhoff, Richelle C Charles, Mohammad Murshid Alam, Tania Sultana, Md Rasheduzzaman Rashu, Amanda Berger, Geoffrey Gonzalez-Escobedo, Anjali Mandlik, Taufiqur Rahman Bhuiyan, Daniel T Leung, Regina C LaRocque, Jason B Harris, Stephen B Calderwood, Firdausi Qadri, W F Vann, Pavol Kováč, Edward T Ryan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4495926?pdf=render

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http://europepmc.org/articles/PMC4495926?pdf=render

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