Magnetic targeting with superparamagnetic iron oxide nanoparticles for in vivo glioma
The purpose of this study was to review the use of the magnetic targeting technique, characterized by magnetic driving compounds based on superparamagnetic iron oxide nanoparticles (SPIONs), as drug delivery for a specific brain locus in gliomas. We reviewed a process mediated by the application of...
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doaj-0e7f0a831b024d6ca1822dbc020097d22021-09-06T19:21:11ZengDe GruyterNanotechnology Reviews2191-90892191-90972017-10-016544947210.1515/ntrev-2016-0101Magnetic targeting with superparamagnetic iron oxide nanoparticles for in vivo gliomaFontes de Paula Aguiar Marina0Bustamante Mamani Javier1Klei Felix Taylla2Ferreira dos Reis Rafael3Rodrigues da Silva Helio4Nucci Leopoldo Penteado5Nucci-da-Silva Mariana Penteado6Gamarra Lionel Fernel7Hospital Israelita Albert Einstein, São Paulo, BrazilHospital Israelita Albert Einstein, São Paulo, BrazilHospital Israelita Albert Einstein, São Paulo, BrazilHospital Israelita Albert Einstein, São Paulo, BrazilHospital Israelita Albert Einstein, São Paulo, BrazilUniversidade Federal de São Paulo, Unifesp, São Paulo, BrazilLIM44, Departamento de Radiologia, USP, São Paulo, BrazilHospital Israelita Albert Einstein, São Paulo, BrazilThe purpose of this study was to review the use of the magnetic targeting technique, characterized by magnetic driving compounds based on superparamagnetic iron oxide nanoparticles (SPIONs), as drug delivery for a specific brain locus in gliomas. We reviewed a process mediated by the application of an external static magnetic field for targeting SPIONs in gliomas. A search of PubMed, Cochrane Library, Scopus, and Web of Science databases identified 228 studies, 23 of which were selected based on inclusion criteria and predetermined exclusion criteria. The articles were analyzed by physicochemical characteristics of SPIONs used, cell types used for tumor induction, characteristics of experimental glioma models, magnetic targeting technical parameters, and analysis method of process efficiency. The study shows the highlights and importance of magnetic targeting to optimize the magnetic targeting process as a therapeutic strategy for gliomas. Regardless of the intensity of the patterned magnetic field, the time of application of the field, and nanoparticle used (commercial or synthesized), all studies showed a vast advantage in the use of magnetic targeting, either alone or in combination with other techniques, for optimized glioma therapy. Therefore, this review elucidates the preclinical and therapeutic applications of magnetic targeting in glioma, an innovative nanobiotechnological method.https://doi.org/10.1515/ntrev-2016-0101external magnetic fieldgliomairon oxidemagnetic targetingtumor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fontes de Paula Aguiar Marina Bustamante Mamani Javier Klei Felix Taylla Ferreira dos Reis Rafael Rodrigues da Silva Helio Nucci Leopoldo Penteado Nucci-da-Silva Mariana Penteado Gamarra Lionel Fernel |
spellingShingle |
Fontes de Paula Aguiar Marina Bustamante Mamani Javier Klei Felix Taylla Ferreira dos Reis Rafael Rodrigues da Silva Helio Nucci Leopoldo Penteado Nucci-da-Silva Mariana Penteado Gamarra Lionel Fernel Magnetic targeting with superparamagnetic iron oxide nanoparticles for in vivo glioma Nanotechnology Reviews external magnetic field glioma iron oxide magnetic targeting tumor |
author_facet |
Fontes de Paula Aguiar Marina Bustamante Mamani Javier Klei Felix Taylla Ferreira dos Reis Rafael Rodrigues da Silva Helio Nucci Leopoldo Penteado Nucci-da-Silva Mariana Penteado Gamarra Lionel Fernel |
author_sort |
Fontes de Paula Aguiar Marina |
title |
Magnetic targeting with superparamagnetic iron oxide nanoparticles for in vivo glioma |
title_short |
Magnetic targeting with superparamagnetic iron oxide nanoparticles for in vivo glioma |
title_full |
Magnetic targeting with superparamagnetic iron oxide nanoparticles for in vivo glioma |
title_fullStr |
Magnetic targeting with superparamagnetic iron oxide nanoparticles for in vivo glioma |
title_full_unstemmed |
Magnetic targeting with superparamagnetic iron oxide nanoparticles for in vivo glioma |
title_sort |
magnetic targeting with superparamagnetic iron oxide nanoparticles for in vivo glioma |
publisher |
De Gruyter |
series |
Nanotechnology Reviews |
issn |
2191-9089 2191-9097 |
publishDate |
2017-10-01 |
description |
The purpose of this study was to review the use of the magnetic targeting technique, characterized by magnetic driving compounds based on superparamagnetic iron oxide nanoparticles (SPIONs), as drug delivery for a specific brain locus in gliomas. We reviewed a process mediated by the application of an external static magnetic field for targeting SPIONs in gliomas. A search of PubMed, Cochrane Library, Scopus, and Web of Science databases identified 228 studies, 23 of which were selected based on inclusion criteria and predetermined exclusion criteria. The articles were analyzed by physicochemical characteristics of SPIONs used, cell types used for tumor induction, characteristics of experimental glioma models, magnetic targeting technical parameters, and analysis method of process efficiency. The study shows the highlights and importance of magnetic targeting to optimize the magnetic targeting process as a therapeutic strategy for gliomas. Regardless of the intensity of the patterned magnetic field, the time of application of the field, and nanoparticle used (commercial or synthesized), all studies showed a vast advantage in the use of magnetic targeting, either alone or in combination with other techniques, for optimized glioma therapy. Therefore, this review elucidates the preclinical and therapeutic applications of magnetic targeting in glioma, an innovative nanobiotechnological method. |
topic |
external magnetic field glioma iron oxide magnetic targeting tumor |
url |
https://doi.org/10.1515/ntrev-2016-0101 |
work_keys_str_mv |
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