Liver Development, Regeneration, and Carcinogenesis
The identification of putative liver stem cells has brought closer the previously separate fields of liver development, regeneration, and carcinogenesis. Significant overlaps in the regulation of these processes are now being described. For example, studies in embryonic liver development have alread...
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doaj-0e8a84e910fd486391af5502bded95fa2020-11-25T01:33:16ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512010-01-01201010.1155/2010/984248984248Liver Development, Regeneration, and CarcinogenesisJanet W. C. Kung0Ian S. Currie1Stuart J. Forbes2James A. Ross3Tissue Injury and Repair Group, Medical Research Council Centre for Regenerative Medicine, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UKTissue Injury and Repair Group, Medical Research Council Centre for Regenerative Medicine, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UKMedical Research Council/University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UKTissue Injury and Repair Group, Medical Research Council Centre for Regenerative Medicine, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UKThe identification of putative liver stem cells has brought closer the previously separate fields of liver development, regeneration, and carcinogenesis. Significant overlaps in the regulation of these processes are now being described. For example, studies in embryonic liver development have already provided the basis for directed differentiation of human embryonic stem cells and induced pluripotent stem cells into hepatocyte-like cells. As a result, the understanding of the cell biology of proliferation and differentiation in the liver has been improved. This knowledge can be used to improve the function of hepatocyte-like cells for drug testing, bioartificial livers, and transplantation. In parallel, the mechanisms regulating cancer cell biology are now clearer, providing fertile soil for novel therapeutic approaches. Recognition of the relationships between development, regeneration, and carcinogenesis, and the increasing evidence for the role of stem cells in all of these areas, has sparked fresh enthusiasm in understanding the underlying molecular mechanisms and has led to new targeted therapies for liver cirrhosis and primary liver cancers.http://dx.doi.org/10.1155/2010/984248 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Janet W. C. Kung Ian S. Currie Stuart J. Forbes James A. Ross |
spellingShingle |
Janet W. C. Kung Ian S. Currie Stuart J. Forbes James A. Ross Liver Development, Regeneration, and Carcinogenesis Journal of Biomedicine and Biotechnology |
author_facet |
Janet W. C. Kung Ian S. Currie Stuart J. Forbes James A. Ross |
author_sort |
Janet W. C. Kung |
title |
Liver Development, Regeneration, and Carcinogenesis |
title_short |
Liver Development, Regeneration, and Carcinogenesis |
title_full |
Liver Development, Regeneration, and Carcinogenesis |
title_fullStr |
Liver Development, Regeneration, and Carcinogenesis |
title_full_unstemmed |
Liver Development, Regeneration, and Carcinogenesis |
title_sort |
liver development, regeneration, and carcinogenesis |
publisher |
Hindawi Limited |
series |
Journal of Biomedicine and Biotechnology |
issn |
1110-7243 1110-7251 |
publishDate |
2010-01-01 |
description |
The identification of putative liver stem cells has brought closer the previously separate fields of liver development, regeneration, and carcinogenesis. Significant overlaps in the regulation of these processes are now being described. For example, studies in embryonic liver development have already provided the basis for directed differentiation of human embryonic stem cells and induced pluripotent stem cells into hepatocyte-like cells. As a result, the understanding of the cell biology of proliferation and differentiation in the liver has been improved. This knowledge can be used to improve the function of hepatocyte-like cells for drug testing, bioartificial livers, and transplantation. In parallel, the mechanisms regulating cancer cell biology are now clearer, providing fertile soil for novel therapeutic approaches. Recognition of the relationships between development, regeneration, and carcinogenesis, and the increasing evidence for the role of stem cells in all of these areas, has sparked fresh enthusiasm in understanding the underlying molecular mechanisms and has led to new targeted therapies for liver cirrhosis and primary liver cancers. |
url |
http://dx.doi.org/10.1155/2010/984248 |
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AT janetwckung liverdevelopmentregenerationandcarcinogenesis AT ianscurrie liverdevelopmentregenerationandcarcinogenesis AT stuartjforbes liverdevelopmentregenerationandcarcinogenesis AT jamesaross liverdevelopmentregenerationandcarcinogenesis |
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