Application of Bioactive Quercetin in Oncotherapy: From Nutrition to Nanomedicine
Phytochemicals as dietary constituents are being explored for their cancer preventive properties. Quercetin is a major constituent of various dietary products and recently its anti-cancer potential has been extensively explored, revealing its anti-proliferative effect on different cancer cell lines,...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2016-01-01
|
Series: | Molecules |
Subjects: | |
Online Access: | http://www.mdpi.com/1420-3049/21/1/108 |
id |
doaj-0e8b0ff5bab4452590f3950eb04d2b9f |
---|---|
record_format |
Article |
spelling |
doaj-0e8b0ff5bab4452590f3950eb04d2b9f2020-11-25T00:02:13ZengMDPI AGMolecules1420-30492016-01-0121110810.3390/molecules21010108molecules21010108Application of Bioactive Quercetin in Oncotherapy: From Nutrition to NanomedicineJu-Suk Nam0Ashish Ranjan Sharma1Lich Thi Nguyen2Chiranjib Chakraborty3Garima Sharma4Sang-Soo Lee5Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 200704, KoreaInstitute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 200704, KoreaInstitute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 200704, KoreaDepartment of Bio-informatics, School of Computer and Information Sciences, Galgotias University, Greater Noida 203201, IndiaInstitute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 200704, KoreaInstitute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 200704, KoreaPhytochemicals as dietary constituents are being explored for their cancer preventive properties. Quercetin is a major constituent of various dietary products and recently its anti-cancer potential has been extensively explored, revealing its anti-proliferative effect on different cancer cell lines, both in vitro and in vivo. Quercetin is known to have modulatory effects on cell apoptosis, migration and growth via various signaling pathways. Though, quercetin possesses great medicinal value, its applications as a therapeutic drug are limited. Problems like low oral bioavailability and poor aqueous solubility make quercetin an unreliable candidate for therapeutic purposes. Additionally, the rapid gastrointestinal digestion of quercetin is also a major barrier for its clinical translation. Hence, to overcome these disadvantages quercetin-based nanoformulations are being considered in recent times. Nanoformulations of quercetin have shown promising results in its uptake by the epithelial system as well as enhanced delivery to the target site. Herein we have tried to summarize various methods utilized for nanofabrication of quercetin formulations and for stable and sustained delivery of quercetin. We have also highlighted the various desirable measures for its use as a promising onco-therapeutic agent.http://www.mdpi.com/1420-3049/21/1/108quercetinanticanceroncotherapybioavailabilitynanoformulationphytochemical |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ju-Suk Nam Ashish Ranjan Sharma Lich Thi Nguyen Chiranjib Chakraborty Garima Sharma Sang-Soo Lee |
spellingShingle |
Ju-Suk Nam Ashish Ranjan Sharma Lich Thi Nguyen Chiranjib Chakraborty Garima Sharma Sang-Soo Lee Application of Bioactive Quercetin in Oncotherapy: From Nutrition to Nanomedicine Molecules quercetin anticancer oncotherapy bioavailability nanoformulation phytochemical |
author_facet |
Ju-Suk Nam Ashish Ranjan Sharma Lich Thi Nguyen Chiranjib Chakraborty Garima Sharma Sang-Soo Lee |
author_sort |
Ju-Suk Nam |
title |
Application of Bioactive Quercetin in Oncotherapy: From Nutrition to Nanomedicine |
title_short |
Application of Bioactive Quercetin in Oncotherapy: From Nutrition to Nanomedicine |
title_full |
Application of Bioactive Quercetin in Oncotherapy: From Nutrition to Nanomedicine |
title_fullStr |
Application of Bioactive Quercetin in Oncotherapy: From Nutrition to Nanomedicine |
title_full_unstemmed |
Application of Bioactive Quercetin in Oncotherapy: From Nutrition to Nanomedicine |
title_sort |
application of bioactive quercetin in oncotherapy: from nutrition to nanomedicine |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2016-01-01 |
description |
Phytochemicals as dietary constituents are being explored for their cancer preventive properties. Quercetin is a major constituent of various dietary products and recently its anti-cancer potential has been extensively explored, revealing its anti-proliferative effect on different cancer cell lines, both in vitro and in vivo. Quercetin is known to have modulatory effects on cell apoptosis, migration and growth via various signaling pathways. Though, quercetin possesses great medicinal value, its applications as a therapeutic drug are limited. Problems like low oral bioavailability and poor aqueous solubility make quercetin an unreliable candidate for therapeutic purposes. Additionally, the rapid gastrointestinal digestion of quercetin is also a major barrier for its clinical translation. Hence, to overcome these disadvantages quercetin-based nanoformulations are being considered in recent times. Nanoformulations of quercetin have shown promising results in its uptake by the epithelial system as well as enhanced delivery to the target site. Herein we have tried to summarize various methods utilized for nanofabrication of quercetin formulations and for stable and sustained delivery of quercetin. We have also highlighted the various desirable measures for its use as a promising onco-therapeutic agent. |
topic |
quercetin anticancer oncotherapy bioavailability nanoformulation phytochemical |
url |
http://www.mdpi.com/1420-3049/21/1/108 |
work_keys_str_mv |
AT jusuknam applicationofbioactivequercetininoncotherapyfromnutritiontonanomedicine AT ashishranjansharma applicationofbioactivequercetininoncotherapyfromnutritiontonanomedicine AT lichthinguyen applicationofbioactivequercetininoncotherapyfromnutritiontonanomedicine AT chiranjibchakraborty applicationofbioactivequercetininoncotherapyfromnutritiontonanomedicine AT garimasharma applicationofbioactivequercetininoncotherapyfromnutritiontonanomedicine AT sangsoolee applicationofbioactivequercetininoncotherapyfromnutritiontonanomedicine |
_version_ |
1725438882570305536 |