Metabolic syndrome in patients with psoriasis: A hospital-based case–control study
Background: Psoriasis is a chronic inflammatory skin disease with an increased risk of cardiovascular disease. Metabolic syndrome (MS) increases the risk of cardiovascular diseases and type 2 diabetes mellitus. Previous studies indicate a higher prevalence of MS in psoriatic patients. Objectives: Th...
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Wolters Kluwer Medknow Publications
2018-01-01
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doaj-0e93b7703554492bb3aa1cbe70779af52021-08-09T09:51:23ZengWolters Kluwer Medknow PublicationsClinical Dermatology Review2542-551X2542-55282018-01-0122646810.4103/CDR.CDR_41_17Metabolic syndrome in patients with psoriasis: A hospital-based case–control studyNarendra GangaiahN S Aysha RoshinVeena ThimmappaRagunatha ShivannaBackground: Psoriasis is a chronic inflammatory skin disease with an increased risk of cardiovascular disease. Metabolic syndrome (MS) increases the risk of cardiovascular diseases and type 2 diabetes mellitus. Previous studies indicate a higher prevalence of MS in psoriatic patients. Objectives: The objective of the study was to determine the frequency of occurrence of MS and its individual components in patients with psoriasis. Methodology: This study was a hospital-based, case–control study involving fifty adult patients with psoriasis and fifty age- and gender-matched controls. Blood pressure, body mass index, waist circumference, fasting lipid profile, and blood sugar were assessed in all subjects. MS was diagnosed by the presence of three or more of the South Asian Modified National Cholesterol Education Program's Adult Treatment Panel III criteria. Results: MS was significantly more common in psoriatic patients than in controls (38% vs. 22%, P = 0.043). Psoriatic patients had higher prevalence of raised fasting blood sugar (32% vs. 16%, P = 0.0334), hypertriglyceridemia (34% vs. 18%, P = 0.037), low high-density lipoprotein (50% vs. 20%, P = 0.00093), and hypertension (38% vs. 20%, P = 0.025). Raised values of waist circumference as a measure of central obesity though not statistically significant (P = 0.08) were found higher in psoriatic cases. The mean age of the psoriatic patients in years was 48 ± 17.1. Mean duration of the disease was 9.2 ± 8 years. There was no correlation between the severity and duration of psoriasis with MS. Conclusion: MS is frequent in patients with psoriasis. This highlights the need for screening of all psoriatic patients for early diagnosis and treatment of associated MS.http://www.cdriadvlkn.org/article.asp?issn=2542-551X;year=2018;volume=2;issue=2;spage=64;epage=68;aulast=Gangaiahbody mass indexdiabetes mellitushypertensionmetabolic syndrome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Narendra Gangaiah N S Aysha Roshin Veena Thimmappa Ragunatha Shivanna |
spellingShingle |
Narendra Gangaiah N S Aysha Roshin Veena Thimmappa Ragunatha Shivanna Metabolic syndrome in patients with psoriasis: A hospital-based case–control study Clinical Dermatology Review body mass index diabetes mellitus hypertension metabolic syndrome |
author_facet |
Narendra Gangaiah N S Aysha Roshin Veena Thimmappa Ragunatha Shivanna |
author_sort |
Narendra Gangaiah |
title |
Metabolic syndrome in patients with psoriasis: A hospital-based case–control study |
title_short |
Metabolic syndrome in patients with psoriasis: A hospital-based case–control study |
title_full |
Metabolic syndrome in patients with psoriasis: A hospital-based case–control study |
title_fullStr |
Metabolic syndrome in patients with psoriasis: A hospital-based case–control study |
title_full_unstemmed |
Metabolic syndrome in patients with psoriasis: A hospital-based case–control study |
title_sort |
metabolic syndrome in patients with psoriasis: a hospital-based case–control study |
publisher |
Wolters Kluwer Medknow Publications |
series |
Clinical Dermatology Review |
issn |
2542-551X 2542-5528 |
publishDate |
2018-01-01 |
description |
Background: Psoriasis is a chronic inflammatory skin disease with an increased risk of cardiovascular disease. Metabolic syndrome (MS) increases the risk of cardiovascular diseases and type 2 diabetes mellitus. Previous studies indicate a higher prevalence of MS in psoriatic patients. Objectives: The objective of the study was to determine the frequency of occurrence of MS and its individual components in patients with psoriasis. Methodology: This study was a hospital-based, case–control study involving fifty adult patients with psoriasis and fifty age- and gender-matched controls. Blood pressure, body mass index, waist circumference, fasting lipid profile, and blood sugar were assessed in all subjects. MS was diagnosed by the presence of three or more of the South Asian Modified National Cholesterol Education Program's Adult Treatment Panel III criteria. Results: MS was significantly more common in psoriatic patients than in controls (38% vs. 22%, P = 0.043). Psoriatic patients had higher prevalence of raised fasting blood sugar (32% vs. 16%, P = 0.0334), hypertriglyceridemia (34% vs. 18%, P = 0.037), low high-density lipoprotein (50% vs. 20%, P = 0.00093), and hypertension (38% vs. 20%, P = 0.025). Raised values of waist circumference as a measure of central obesity though not statistically significant (P = 0.08) were found higher in psoriatic cases. The mean age of the psoriatic patients in years was 48 ± 17.1. Mean duration of the disease was 9.2 ± 8 years. There was no correlation between the severity and duration of psoriasis with MS. Conclusion: MS is frequent in patients with psoriasis. This highlights the need for screening of all psoriatic patients for early diagnosis and treatment of associated MS. |
topic |
body mass index diabetes mellitus hypertension metabolic syndrome |
url |
http://www.cdriadvlkn.org/article.asp?issn=2542-551X;year=2018;volume=2;issue=2;spage=64;epage=68;aulast=Gangaiah |
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