Neoadjuvant combination therapy with trastuzumab in a breast cancer patient with synchronous rectal carcinoma: a case report and biomarker study
We report a patient who presented with synchronous second primary human epidermal growth factor receptor (HER)-2-positive breast cancer and rectal cancer that both required simultaneous neoadjuvant therapy. A modified regimen combining anti-HER-2 monoclonal antibody trastuzumab with chemotherapy and...
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doaj-0e9bfb0b26e946608fdd6f4bb8f4082f2021-09-05T13:59:57ZengDe GruyterPteridines0933-48072195-47202017-12-01283-423324110.1515/pterid-2017-0017Neoadjuvant combination therapy with trastuzumab in a breast cancer patient with synchronous rectal carcinoma: a case report and biomarker studyVitásková Denisa0Melichar Bohuslav1Bartoušková Marie2Vlachová Zuzana3Vrána David4Janková Jana5Adam Tomáš6Juráňová Jarmila7Zlámalová Nora8Kujovská Krčmová Lenka9Javorská Lenka10Klos Dušan11Študentová Hana12Department of Oncology, Palacký University Medical School and Teaching Hospital, I.P. Pavlova 6, 779 00 Olomouc, Czech RepublicDepartment of Oncology, Palacký University Medical School and Teaching Hospital, I.P. Pavlova 6, 779 00 Olomouc, Czech RepublicDepartment of Oncology, Palacký University Medical School and Teaching Hospital, I.P. Pavlova 6, 779 00 Olomouc, Czech RepublicDepartment of Oncology, Palacký University Medical School and Teaching Hospital, I.P. Pavlova 6, 779 00 Olomouc, Czech RepublicDepartment of Oncology, Palacký University Medical School and Teaching Hospital, I.P. Pavlova 6, 779 00 Olomouc, Czech RepublicInstitute of Molecular and Clinical Pathology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech RepublicInstitute of Molecular and Translational Medicine, Palacký University Medical School and Teaching Hospital, Olomouc, Czech RepublicDepartment of Hemato-Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech RepublicFirst Department of Surgery, Palacký University Medical School and Teaching Hospital, I.P. Pavlova 6, 779 00 Olomouc, Czech RepublicThird Department of Medicine (Gerontology and Metabolic Care), Charles University Teaching Hospital, Hradec Králové, Czech RepublicThird Department of Medicine (Gerontology and Metabolic Care), Charles University Teaching Hospital, Hradec Králové, Czech RepublicFirst Department of Surgery, Palacký University Medical School and Teaching Hospital, I.P. Pavlova 6, 779 00 Olomouc, Czech RepublicDepartment of Oncology, Palacký University Medical School and Teaching Hospital, I.P. Pavlova 6, 779 00 Olomouc, Czech RepublicWe report a patient who presented with synchronous second primary human epidermal growth factor receptor (HER)-2-positive breast cancer and rectal cancer that both required simultaneous neoadjuvant therapy. A modified regimen combining anti-HER-2 monoclonal antibody trastuzumab with chemotherapy and external beam radiation was selected. An organ-preserving surgical procedure was possible both in the breast and the rectum. Citrulline decreased rapidly after the start of the treatment, and then gradually returned to pre-treatment levels after the completion of chemoradiation. Urinary neopterin concentrations exhibited a fluctuating course. Both serum neopterin and C-reactive protein concentrations were more or less stable during the initial administration of trastuzumab, paclitaxel and carboplatin and then increased steeply during chemoradiation and subsequently declined to pre-treatment levels during the weekly trastuzumab administration. Changes were observed in the serum retinol concentrations. A decline in lymphocyte counts was accompanied by marked changes in peripheral blood cell count-derived ratios. The present case report demonstrates a successful combination of two neoadjuvant regimens in a patient with two synchronous different second primary tumors. Data from this case also illustrate the use of biomarkers for monitoring of intensive therapeutic regimens in medical and radiation oncology.https://doi.org/10.1515/pterid-2017-0017breast cancerchemoradiationneoadjuvant therapyneopterintrastuzumab |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vitásková Denisa Melichar Bohuslav Bartoušková Marie Vlachová Zuzana Vrána David Janková Jana Adam Tomáš Juráňová Jarmila Zlámalová Nora Kujovská Krčmová Lenka Javorská Lenka Klos Dušan Študentová Hana |
spellingShingle |
Vitásková Denisa Melichar Bohuslav Bartoušková Marie Vlachová Zuzana Vrána David Janková Jana Adam Tomáš Juráňová Jarmila Zlámalová Nora Kujovská Krčmová Lenka Javorská Lenka Klos Dušan Študentová Hana Neoadjuvant combination therapy with trastuzumab in a breast cancer patient with synchronous rectal carcinoma: a case report and biomarker study Pteridines breast cancer chemoradiation neoadjuvant therapy neopterin trastuzumab |
author_facet |
Vitásková Denisa Melichar Bohuslav Bartoušková Marie Vlachová Zuzana Vrána David Janková Jana Adam Tomáš Juráňová Jarmila Zlámalová Nora Kujovská Krčmová Lenka Javorská Lenka Klos Dušan Študentová Hana |
author_sort |
Vitásková Denisa |
title |
Neoadjuvant combination therapy with trastuzumab in a breast cancer patient with synchronous rectal carcinoma: a case report and biomarker study |
title_short |
Neoadjuvant combination therapy with trastuzumab in a breast cancer patient with synchronous rectal carcinoma: a case report and biomarker study |
title_full |
Neoadjuvant combination therapy with trastuzumab in a breast cancer patient with synchronous rectal carcinoma: a case report and biomarker study |
title_fullStr |
Neoadjuvant combination therapy with trastuzumab in a breast cancer patient with synchronous rectal carcinoma: a case report and biomarker study |
title_full_unstemmed |
Neoadjuvant combination therapy with trastuzumab in a breast cancer patient with synchronous rectal carcinoma: a case report and biomarker study |
title_sort |
neoadjuvant combination therapy with trastuzumab in a breast cancer patient with synchronous rectal carcinoma: a case report and biomarker study |
publisher |
De Gruyter |
series |
Pteridines |
issn |
0933-4807 2195-4720 |
publishDate |
2017-12-01 |
description |
We report a patient who presented with synchronous second primary human epidermal growth factor receptor (HER)-2-positive breast cancer and rectal cancer that both required simultaneous neoadjuvant therapy. A modified regimen combining anti-HER-2 monoclonal antibody trastuzumab with chemotherapy and external beam radiation was selected. An organ-preserving surgical procedure was possible both in the breast and the rectum. Citrulline decreased rapidly after the start of the treatment, and then gradually returned to pre-treatment levels after the completion of chemoradiation. Urinary neopterin concentrations exhibited a fluctuating course. Both serum neopterin and C-reactive protein concentrations were more or less stable during the initial administration of trastuzumab, paclitaxel and carboplatin and then increased steeply during chemoradiation and subsequently declined to pre-treatment levels during the weekly trastuzumab administration. Changes were observed in the serum retinol concentrations. A decline in lymphocyte counts was accompanied by marked changes in peripheral blood cell count-derived ratios. The present case report demonstrates a successful combination of two neoadjuvant regimens in a patient with two synchronous different second primary tumors. Data from this case also illustrate the use of biomarkers for monitoring of intensive therapeutic regimens in medical and radiation oncology. |
topic |
breast cancer chemoradiation neoadjuvant therapy neopterin trastuzumab |
url |
https://doi.org/10.1515/pterid-2017-0017 |
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