FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis
The cytokine like protein FAM3D (Fam3D in mice) is highly expressed in the digestive tract with unknown role in colon pathophysiology. Here, by using gene deficient mice, the authors show that Fam3D is critically involved in colon homeostasis, host defense against colitis-associated carcinogenesis,...
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Nature Publishing Group
2020-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19691-z |
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doaj-0ea1abe3c3234932b77c2016848d7dc02021-05-11T08:53:33ZengNature Publishing GroupNature Communications2041-17232020-11-0111111610.1038/s41467-020-19691-zFAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesisWeiwei Liang0Xinjian Peng1Qingqing Li2Pingzhang Wang3Ping Lv4Quansheng Song5Shaoping She6Shiyang Huang7Keqiang Chen8Wanghua Gong9Wuxing Yuan10Vishal Thovarai11Teizo Yoshimura12Colm O’huigin13Giorgio Trinchieri14Jiaqiang Huang15Shuye Lin16Xiaohong Yao17Xiuwu Bian18Wei Kong19Jianzhong Xi20Ji Ming Wang21Ying Wang22Department of Immunology, School of Basic Medical Sciences and NHC Key Laboratory of Medical Immunology, Peking UniversityDepartment of Immunology, School of Basic Medical Sciences and NHC Key Laboratory of Medical Immunology, Peking UniversityDepartment of Immunology, School of Basic Medical Sciences and NHC Key Laboratory of Medical Immunology, Peking UniversityDepartment of Immunology, School of Basic Medical Sciences and NHC Key Laboratory of Medical Immunology, Peking UniversityDepartment of Immunology, School of Basic Medical Sciences and NHC Key Laboratory of Medical Immunology, Peking UniversityDepartment of Immunology, School of Basic Medical Sciences and NHC Key Laboratory of Medical Immunology, Peking UniversityDepartment of Immunology, School of Basic Medical Sciences and NHC Key Laboratory of Medical Immunology, Peking UniversityDepartment of Immunology, School of Basic Medical Sciences and NHC Key Laboratory of Medical Immunology, Peking UniversityCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at FrederickBasic Research Program, Leidos Biomedical Research, IncMicrobiome Sequencing Core, Leidos Biomedical Research, IncBasic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer ResearchDepartment of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama UniversityCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at FrederickCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at FrederickCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at FrederickCancer Research Center, Beijing Chest Hospital affiliated to Capital Medical University, Beijing Tuberculosis & Thoracic Tumor Research InstituteInstitute of Pathology, South-west Hospital and Cancer CenterInstitute of Pathology, South-west Hospital and Cancer CenterDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking UniversityDepartment of Biomedicine, College of Engineering, Peking UniversityCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at FrederickDepartment of Immunology, School of Basic Medical Sciences and NHC Key Laboratory of Medical Immunology, Peking UniversityThe cytokine like protein FAM3D (Fam3D in mice) is highly expressed in the digestive tract with unknown role in colon pathophysiology. Here, by using gene deficient mice, the authors show that Fam3D is critically involved in colon homeostasis, host defense against colitis-associated carcinogenesis, and the balance of microbiota.https://doi.org/10.1038/s41467-020-19691-z |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Weiwei Liang Xinjian Peng Qingqing Li Pingzhang Wang Ping Lv Quansheng Song Shaoping She Shiyang Huang Keqiang Chen Wanghua Gong Wuxing Yuan Vishal Thovarai Teizo Yoshimura Colm O’huigin Giorgio Trinchieri Jiaqiang Huang Shuye Lin Xiaohong Yao Xiuwu Bian Wei Kong Jianzhong Xi Ji Ming Wang Ying Wang |
| spellingShingle |
Weiwei Liang Xinjian Peng Qingqing Li Pingzhang Wang Ping Lv Quansheng Song Shaoping She Shiyang Huang Keqiang Chen Wanghua Gong Wuxing Yuan Vishal Thovarai Teizo Yoshimura Colm O’huigin Giorgio Trinchieri Jiaqiang Huang Shuye Lin Xiaohong Yao Xiuwu Bian Wei Kong Jianzhong Xi Ji Ming Wang Ying Wang FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis Nature Communications |
| author_facet |
Weiwei Liang Xinjian Peng Qingqing Li Pingzhang Wang Ping Lv Quansheng Song Shaoping She Shiyang Huang Keqiang Chen Wanghua Gong Wuxing Yuan Vishal Thovarai Teizo Yoshimura Colm O’huigin Giorgio Trinchieri Jiaqiang Huang Shuye Lin Xiaohong Yao Xiuwu Bian Wei Kong Jianzhong Xi Ji Ming Wang Ying Wang |
| author_sort |
Weiwei Liang |
| title |
FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis |
| title_short |
FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis |
| title_full |
FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis |
| title_fullStr |
FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis |
| title_full_unstemmed |
FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis |
| title_sort |
fam3d is essential for colon homeostasis and host defense against inflammation associated carcinogenesis |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-11-01 |
| description |
The cytokine like protein FAM3D (Fam3D in mice) is highly expressed in the digestive tract with unknown role in colon pathophysiology. Here, by using gene deficient mice, the authors show that Fam3D is critically involved in colon homeostasis, host defense against colitis-associated carcinogenesis, and the balance of microbiota. |
| url |
https://doi.org/10.1038/s41467-020-19691-z |
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