Cutaneous Squamous Cell Carcinoma Tumour Size is Associated with Sentinel Lymph Node Metastasis in a Cohort of 69 Patients
Ten to fifty percent of high-risk cutaneous squamous cell carcinoma may potentially metastasize. However, the concept of sentinel lymph node biopsy remains controversial for cutaneous squamous cell carcinoma. The aim of this study was to identify prognostic factors associated with sentinel lymph nod...
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Society for Publication of Acta Dermato-Venereologica
2019-10-01
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doaj-0ea3ddc10afe490ab94447b94fa50a812020-11-24T21:52:58ZengSociety for Publication of Acta Dermato-VenereologicaActa Dermato-Venereologica0001-55551651-20572019-10-0199131241124510.2340/00015555-32935559Cutaneous Squamous Cell Carcinoma Tumour Size is Associated with Sentinel Lymph Node Metastasis in a Cohort of 69 PatientsEmilien Chabrillac0Amélie LusqueZoé CavallierRaphaël LopezThomas FilleronJérôme SariniNicolas MeyerSébastien Vergez Department of ENT-Head and Neck Surgery, University Cancer Institute Toulouse and Toulouse University Hospital, Hôpital Larrey, FR-31400 Toulouse, France. chabrillac.e@chu-toulouse.fr. Ten to fifty percent of high-risk cutaneous squamous cell carcinoma may potentially metastasize. However, the concept of sentinel lymph node biopsy remains controversial for cutaneous squamous cell carcinoma. The aim of this study was to identify prognostic factors associated with sentinel lymph node positivity. A bicentric retrospective analysis was conducted between January 2006 and January 2018. All patients undergoing sentinel lymph node biopsy for high-risk cutaneous squamous cell carcinoma were included, based on the criteria of the prognostic classification of the French Society of Dermatology. Seventy-four patients were included. Five (6.8%) procedures failed. Of the 69 patients assessed, the positive sentinel lymph node biopsy rate was 11.6% (n = 8) with a false negative rate of 5.7% (n = 4). The positivity of sentinel lymph node biopsy was associated with tumour size (p = 0.0194). Sentinel lymph node biopsy is an effective staging procedure for clinically N0 high-risk cutaneous squamous cell carcinoma, with an acceptable morbidity. To date, 2 risk factors of sentinel lymph node positivity have been identified with statistical significance: tumour size and poor tumour differentiation. https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3293 high-risk cutaneous squamous cell carcinoma sentinel lymph node biopsy risk factor tumour size |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Emilien Chabrillac Amélie Lusque Zoé Cavallier Raphaël Lopez Thomas Filleron Jérôme Sarini Nicolas Meyer Sébastien Vergez |
spellingShingle |
Emilien Chabrillac Amélie Lusque Zoé Cavallier Raphaël Lopez Thomas Filleron Jérôme Sarini Nicolas Meyer Sébastien Vergez Cutaneous Squamous Cell Carcinoma Tumour Size is Associated with Sentinel Lymph Node Metastasis in a Cohort of 69 Patients Acta Dermato-Venereologica high-risk cutaneous squamous cell carcinoma sentinel lymph node biopsy risk factor tumour size |
author_facet |
Emilien Chabrillac Amélie Lusque Zoé Cavallier Raphaël Lopez Thomas Filleron Jérôme Sarini Nicolas Meyer Sébastien Vergez |
author_sort |
Emilien Chabrillac |
title |
Cutaneous Squamous Cell Carcinoma Tumour Size is Associated with Sentinel Lymph Node Metastasis in a Cohort of 69 Patients |
title_short |
Cutaneous Squamous Cell Carcinoma Tumour Size is Associated with Sentinel Lymph Node Metastasis in a Cohort of 69 Patients |
title_full |
Cutaneous Squamous Cell Carcinoma Tumour Size is Associated with Sentinel Lymph Node Metastasis in a Cohort of 69 Patients |
title_fullStr |
Cutaneous Squamous Cell Carcinoma Tumour Size is Associated with Sentinel Lymph Node Metastasis in a Cohort of 69 Patients |
title_full_unstemmed |
Cutaneous Squamous Cell Carcinoma Tumour Size is Associated with Sentinel Lymph Node Metastasis in a Cohort of 69 Patients |
title_sort |
cutaneous squamous cell carcinoma tumour size is associated with sentinel lymph node metastasis in a cohort of 69 patients |
publisher |
Society for Publication of Acta Dermato-Venereologica |
series |
Acta Dermato-Venereologica |
issn |
0001-5555 1651-2057 |
publishDate |
2019-10-01 |
description |
Ten to fifty percent of high-risk cutaneous squamous cell carcinoma may potentially metastasize. However, the concept of sentinel lymph node biopsy remains controversial for cutaneous squamous cell carcinoma. The aim of this study was to identify prognostic factors associated with sentinel lymph node positivity. A bicentric retrospective analysis was conducted between January 2006 and January 2018. All patients undergoing sentinel lymph node biopsy for high-risk cutaneous squamous cell carcinoma were included, based on the criteria of the prognostic classification of the French Society of Dermatology. Seventy-four patients were included. Five (6.8%) procedures failed. Of the 69 patients assessed, the positive sentinel lymph node biopsy rate was 11.6% (n = 8) with a false negative rate of 5.7% (n = 4). The positivity of sentinel lymph node biopsy was associated with tumour size (p = 0.0194). Sentinel lymph node biopsy is an effective staging procedure for clinically N0 high-risk cutaneous squamous cell carcinoma, with an acceptable morbidity. To date, 2 risk factors of sentinel lymph node positivity have been identified with statistical significance: tumour size and poor tumour differentiation. |
topic |
high-risk cutaneous squamous cell carcinoma sentinel lymph node biopsy risk factor tumour size |
url |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3293
|
work_keys_str_mv |
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