THE EFFECTS OF AEROBIC EXERCISE ON SKELETAL MUSCLE METABOLISM, MORPHOLOGY AND IN SITU ENDURANCE IN DIABETIC RATS
The effects of aerobic exercise training on skeletal muscle endurance capacity were examined in diabetic rats in situ. Moderate diabetes was induced by iv injection of streptozotocin and an exercise training program on a treadmill was carried out for 8 weeks. The animals randomly assigned to one of...
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University of Uludag
2005-12-01
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doaj-0eaef7cf85d645cc9fce2f1cabf443de2020-11-24T22:27:11ZengUniversity of UludagJournal of Sports Science and Medicine1303-29682005-12-0144472481THE EFFECTS OF AEROBIC EXERCISE ON SKELETAL MUSCLE METABOLISM, MORPHOLOGY AND IN SITU ENDURANCE IN DIABETIC RATSNilay ErgenHatice KurdakSeref ErdoganUfuk Ozgü MeteMehmet KayaNurten DikmenAyşe DoğanSanli Sadi KurdakThe effects of aerobic exercise training on skeletal muscle endurance capacity were examined in diabetic rats in situ. Moderate diabetes was induced by iv injection of streptozotocin and an exercise training program on a treadmill was carried out for 8 weeks. The animals randomly assigned to one of the four experimental groups: control-sedentary (CS), control-exercise (CE), diabetic-sedentary (DS) or diabetic-exercise (DE). The changes in the muscle endurance capacity were evaluated through the square wave impulses (supramaximal) of 0.2-ms duration at 1 Hz in the in situ gastrocnemius-soleus muscle complex. Muscle was stimulated continuously until tension development reduced to the half of this maximal value. Time interval between the beginning and the end of stimulation period is defined as contraction duration. Following the training period, blood glucose level reduced significantly in the DE group compared to DS group (p < 0.05). The soles muscle citrate synthase activity was increased significantly in both of the trained groups compared to sedentary animals (p < 0.05). Fatigued muscle lactate values were not significantly different from each other. Ultrastractural abnormality of the skeletal muscle in DS group disappeared with training. Presence of increased lipid droplets, mitochondria clusters and glycogen accumulation was observed in the skeletal muscle of DE group. The contraction duration was longer in the DE group than others (p < 0.001). Fatigue resistance of exercised diabetic animals may be explained by increased intramyocellular lipid droplets, high blood glucose level and muscle citrate synthase activityhttp://www.jssm.org/vol4/n4/14/v4n4-14text.phpTrainingcitrate synthasemuscle enduranceultrastructurediabetes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nilay Ergen Hatice Kurdak Seref Erdogan Ufuk Ozgü Mete Mehmet Kaya Nurten Dikmen Ayşe Doğan Sanli Sadi Kurdak |
spellingShingle |
Nilay Ergen Hatice Kurdak Seref Erdogan Ufuk Ozgü Mete Mehmet Kaya Nurten Dikmen Ayşe Doğan Sanli Sadi Kurdak THE EFFECTS OF AEROBIC EXERCISE ON SKELETAL MUSCLE METABOLISM, MORPHOLOGY AND IN SITU ENDURANCE IN DIABETIC RATS Journal of Sports Science and Medicine Training citrate synthase muscle endurance ultrastructure diabetes |
author_facet |
Nilay Ergen Hatice Kurdak Seref Erdogan Ufuk Ozgü Mete Mehmet Kaya Nurten Dikmen Ayşe Doğan Sanli Sadi Kurdak |
author_sort |
Nilay Ergen |
title |
THE EFFECTS OF AEROBIC EXERCISE ON SKELETAL MUSCLE METABOLISM, MORPHOLOGY AND IN SITU ENDURANCE IN DIABETIC RATS |
title_short |
THE EFFECTS OF AEROBIC EXERCISE ON SKELETAL MUSCLE METABOLISM, MORPHOLOGY AND IN SITU ENDURANCE IN DIABETIC RATS |
title_full |
THE EFFECTS OF AEROBIC EXERCISE ON SKELETAL MUSCLE METABOLISM, MORPHOLOGY AND IN SITU ENDURANCE IN DIABETIC RATS |
title_fullStr |
THE EFFECTS OF AEROBIC EXERCISE ON SKELETAL MUSCLE METABOLISM, MORPHOLOGY AND IN SITU ENDURANCE IN DIABETIC RATS |
title_full_unstemmed |
THE EFFECTS OF AEROBIC EXERCISE ON SKELETAL MUSCLE METABOLISM, MORPHOLOGY AND IN SITU ENDURANCE IN DIABETIC RATS |
title_sort |
effects of aerobic exercise on skeletal muscle metabolism, morphology and in situ endurance in diabetic rats |
publisher |
University of Uludag |
series |
Journal of Sports Science and Medicine |
issn |
1303-2968 |
publishDate |
2005-12-01 |
description |
The effects of aerobic exercise training on skeletal muscle endurance capacity were examined in diabetic rats in situ. Moderate diabetes was induced by iv injection of streptozotocin and an exercise training program on a treadmill was carried out for 8 weeks. The animals randomly assigned to one of the four experimental groups: control-sedentary (CS), control-exercise (CE), diabetic-sedentary (DS) or diabetic-exercise (DE). The changes in the muscle endurance capacity were evaluated through the square wave impulses (supramaximal) of 0.2-ms duration at 1 Hz in the in situ gastrocnemius-soleus muscle complex. Muscle was stimulated continuously until tension development reduced to the half of this maximal value. Time interval between the beginning and the end of stimulation period is defined as contraction duration. Following the training period, blood glucose level reduced significantly in the DE group compared to DS group (p < 0.05). The soles muscle citrate synthase activity was increased significantly in both of the trained groups compared to sedentary animals (p < 0.05). Fatigued muscle lactate values were not significantly different from each other. Ultrastractural abnormality of the skeletal muscle in DS group disappeared with training. Presence of increased lipid droplets, mitochondria clusters and glycogen accumulation was observed in the skeletal muscle of DE group. The contraction duration was longer in the DE group than others (p < 0.001). Fatigue resistance of exercised diabetic animals may be explained by increased intramyocellular lipid droplets, high blood glucose level and muscle citrate synthase activity |
topic |
Training citrate synthase muscle endurance ultrastructure diabetes |
url |
http://www.jssm.org/vol4/n4/14/v4n4-14text.php |
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