Haemoglobin C and S role in acquired immunity against Plasmodium falciparum malaria.
A recently proposed mechanism of protection for haemoglobin C (HbC; beta6Glu-->Lys) links an abnormal display of PfEMP1, an antigen involved in malaria pathogenesis, on the surface of HbC infected erythrocytes together with the observation of reduced cytoadhesion of parasitized erythrocytes and i...
Main Authors: | Federica Verra, Jacques Simpore, George M Warimwe, Kevin K Tetteh, Tevis Howard, Faith H A Osier, Germana Bancone, Pamela Avellino, Isa Blot, Greg Fegan, Peter C Bull, Thomas N Williams, David J Conway, Kevin Marsh, David Modiano |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2007-10-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC1991593?pdf=render |
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