Intra-arterial chemotherapy for retinoblastoma: First Indian report
Aim: To describe treatment outcomes and complications of selective intra-arterial chemotherapy (IAC) for retinoblastoma (RB) in Indian eyes. Materials and Methods: Single center, retrospective interventional case series of 6 eyes with RB who underwent IAC using Melphalan (3 mg/5 mg/7.5 mg) and topet...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2015-01-01
|
Series: | Indian Journal of Ophthalmology |
Subjects: | |
Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2015;volume=63;issue=4;spage=331;epage=334;aulast=Rishi |
id |
doaj-0eb6188827f8428796ccd26590c8c9c4 |
---|---|
record_format |
Article |
spelling |
doaj-0eb6188827f8428796ccd26590c8c9c42020-11-24T22:27:11ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892015-01-0163433133410.4103/0301-4738.158076Intra-arterial chemotherapy for retinoblastoma: First Indian reportPukhraj RishiTarun SharmaVikram KoundanyaNishat BansalM SaravananR RavikumarSatheesh RamamurthyAim: To describe treatment outcomes and complications of selective intra-arterial chemotherapy (IAC) for retinoblastoma (RB) in Indian eyes. Materials and Methods: Single center, retrospective interventional case series of 6 eyes with RB who underwent IAC using Melphalan (3 mg/5 mg/7.5 mg) and topetecan (1 mg) (n = 4) or melphalan (3 mg/5 mg/7.5 mg) alone (n = 2) between December 2013 and June 2014. In all, 17 IAC procedures were performed using selective ophthalmic artery cannulation. Treatment outcomes were evaluated in terms of tumor control, vitreous and subretinal seeds control and globe salvage rates. Results: IAC was employed as primary (n = 1) or secondary (n = 5) modality of treatment. Each eye received mean 3 IAC sessions (median: 3; range: 1-4 sessions). Eyes were classified according to international classification of RB as Group B (n = 1), C (n = 1), D (n = 2) and E (n = 2). Following IAC, complete regression of the main tumor was seen in 3 cases (50%), partial regression in 2 (33%), while 1 case (15%) showed no response. Of 4 eyes with subretinal seeds, 1 (25%) eye had complete regression while 3 (75%) eyes had partial regression. Of 5 eyes with vitreous seeds, 2 (40%) eyes had complete regression while 3 (60%) eyes had a partial response. Globe salvage was achieved in 5 of 6 eyes (83%). Diffuse choroidal atrophy and vitreous hemorrhage were observed in 1 (17%) eye, each. No hematologic toxicity or cerebro-vascular events were observed. Mean follow-up period was 5.5 months (median: 6 months, range: 1-6 months). Conclusion: IAC is an effective therapy for globe preservation in eyes with RB. Larger studies with longer follow-up are required to validate these results.http://www.ijo.in/article.asp?issn=0301-4738;year=2015;volume=63;issue=4;spage=331;epage=334;aulast=RishiAdvanced glaucomaoptical coherence tomographyreproducibilityretinal nerve fiber layer thicknessspectral domainOphthalmologyresidentssurgical trainingsurveyCytokinediabetic macular edemaoptical coherence tomographyMacular GHPCpulse cyclophosphamideserpiginous choroidopathyContact lensCorvis STintraocular pressure Confocal microscopymeibomian glandmeibomian gland microenvironmentpapillary formationvernal keratoconjunctivitisEyeintra-arterial chemotherapyretinoblastomatumor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pukhraj Rishi Tarun Sharma Vikram Koundanya Nishat Bansal M Saravanan R Ravikumar Satheesh Ramamurthy |
spellingShingle |
Pukhraj Rishi Tarun Sharma Vikram Koundanya Nishat Bansal M Saravanan R Ravikumar Satheesh Ramamurthy Intra-arterial chemotherapy for retinoblastoma: First Indian report Indian Journal of Ophthalmology Advanced glaucoma optical coherence tomography reproducibility retinal nerve fiber layer thickness spectral domain Ophthalmology residents surgical training survey Cytokine diabetic macular edema optical coherence tomography Macular GHPC pulse cyclophosphamide serpiginous choroidopathy Contact lens Corvis ST intraocular pressure Confocal microscopy meibomian gland meibomian gland microenvironment papillary formation vernal keratoconjunctivitis Eye intra-arterial chemotherapy retinoblastoma tumor |
author_facet |
Pukhraj Rishi Tarun Sharma Vikram Koundanya Nishat Bansal M Saravanan R Ravikumar Satheesh Ramamurthy |
author_sort |
Pukhraj Rishi |
title |
Intra-arterial chemotherapy for retinoblastoma: First Indian report |
title_short |
Intra-arterial chemotherapy for retinoblastoma: First Indian report |
title_full |
Intra-arterial chemotherapy for retinoblastoma: First Indian report |
title_fullStr |
Intra-arterial chemotherapy for retinoblastoma: First Indian report |
title_full_unstemmed |
Intra-arterial chemotherapy for retinoblastoma: First Indian report |
title_sort |
intra-arterial chemotherapy for retinoblastoma: first indian report |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Ophthalmology |
issn |
0301-4738 1998-3689 |
publishDate |
2015-01-01 |
description |
Aim: To describe treatment outcomes and complications of selective intra-arterial chemotherapy (IAC) for retinoblastoma (RB) in Indian eyes. Materials and Methods: Single center, retrospective interventional case series of 6 eyes with RB who underwent IAC using Melphalan (3 mg/5 mg/7.5 mg) and topetecan (1 mg) (n = 4) or melphalan (3 mg/5 mg/7.5 mg) alone (n = 2) between December 2013 and June 2014. In all, 17 IAC procedures were performed using selective ophthalmic artery cannulation. Treatment outcomes were evaluated in terms of tumor control, vitreous and subretinal seeds control and globe salvage rates. Results: IAC was employed as primary (n = 1) or secondary (n = 5) modality of treatment. Each eye received mean 3 IAC sessions (median: 3; range: 1-4 sessions). Eyes were classified according to international classification of RB as Group B (n = 1), C (n = 1), D (n = 2) and E (n = 2). Following IAC, complete regression of the main tumor was seen in 3 cases (50%), partial regression in 2 (33%), while 1 case (15%) showed no response. Of 4 eyes with subretinal seeds, 1 (25%) eye had complete regression while 3 (75%) eyes had partial regression. Of 5 eyes with vitreous seeds, 2 (40%) eyes had complete regression while 3 (60%) eyes had a partial response. Globe salvage was achieved in 5 of 6 eyes (83%). Diffuse choroidal atrophy and vitreous hemorrhage were observed in 1 (17%) eye, each. No hematologic toxicity or cerebro-vascular events were observed. Mean follow-up period was 5.5 months (median: 6 months, range: 1-6 months). Conclusion: IAC is an effective therapy for globe preservation in eyes with RB. Larger studies with longer follow-up are required to validate these results. |
topic |
Advanced glaucoma optical coherence tomography reproducibility retinal nerve fiber layer thickness spectral domain Ophthalmology residents surgical training survey Cytokine diabetic macular edema optical coherence tomography Macular GHPC pulse cyclophosphamide serpiginous choroidopathy Contact lens Corvis ST intraocular pressure Confocal microscopy meibomian gland meibomian gland microenvironment papillary formation vernal keratoconjunctivitis Eye intra-arterial chemotherapy retinoblastoma tumor |
url |
http://www.ijo.in/article.asp?issn=0301-4738;year=2015;volume=63;issue=4;spage=331;epage=334;aulast=Rishi |
work_keys_str_mv |
AT pukhrajrishi intraarterialchemotherapyforretinoblastomafirstindianreport AT tarunsharma intraarterialchemotherapyforretinoblastomafirstindianreport AT vikramkoundanya intraarterialchemotherapyforretinoblastomafirstindianreport AT nishatbansal intraarterialchemotherapyforretinoblastomafirstindianreport AT msaravanan intraarterialchemotherapyforretinoblastomafirstindianreport AT rravikumar intraarterialchemotherapyforretinoblastomafirstindianreport AT satheeshramamurthy intraarterialchemotherapyforretinoblastomafirstindianreport |
_version_ |
1725750986353410048 |