Circular RNA screening from EIF3a in lung cancer
Abstract Eukaryotic initiation factor 3 (EIF3) is one of the largest and most complex translation initiation factors, which consists of 13 subunits named eukaryotic translation initiation factor 3 subunit A (EIF3a) to EIF3m. EIF3a is the largest subunit of EIF3. Previous studies suggested that EIF3a...
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doaj-0ecdc7e8e6684f839cd21198fbc0913b2020-11-24T22:07:39ZengWileyCancer Medicine2045-76342019-08-01894159416810.1002/cam4.2338Circular RNA screening from EIF3a in lung cancerMa‐Sha Huang0Fu‐Qiang Yuan1Yang Gao2Jun‐Yan Liu3Yi‐Xin Chen4Chen‐Jing Wang5Bai‐Mei He6Hong‐Hao Zhou7Zhao‐Qian Liu8Department of Clinical Pharmacology Xiangya Hospital, Central South University Changsha P. R. ChinaDepartment of Clinical Pharmacology Xiangya Hospital, Central South University Changsha P. R. ChinaDepartment of Clinical Pharmacology Xiangya Hospital, Central South University Changsha P. R. ChinaDepartment of Clinical Pharmacology Xiangya Hospital, Central South University Changsha P. R. ChinaDepartment of Clinical Pharmacology Xiangya Hospital, Central South University Changsha P. R. ChinaDepartment of Clinical Pharmacology Xiangya Hospital, Central South University Changsha P. R. ChinaDepartment of Clinical Pharmacology Xiangya Hospital, Central South University Changsha P. R. ChinaDepartment of Clinical Pharmacology Xiangya Hospital, Central South University Changsha P. R. ChinaDepartment of Clinical Pharmacology Xiangya Hospital, Central South University Changsha P. R. ChinaAbstract Eukaryotic initiation factor 3 (EIF3) is one of the largest and most complex translation initiation factors, which consists of 13 subunits named eukaryotic translation initiation factor 3 subunit A (EIF3a) to EIF3m. EIF3a is the largest subunit of EIF3. Previous studies suggested that EIF3a is a housekeeping gene, recent results have found that EIF3a is closely related to the tumorigenesis and drug resistance. Circular RNAs (circRNAs) derived from biologically important gene can play an important role in gene regulation. However, the mechanism underlying circRNAs’ biological functions is not well understood yet. In this work, we screened 31 EIF3a‐derived circRNAs, in which two circEIF3as were identified to be correlated with cisplatin drug sensitivity in lung cancer. Two circEIF3as were found involved in RNA‐binding proteins‐mediated biological processes and may be related to translational regulation according to bioinformatics analyses. CircEIF3as, the transcriptional initiation factor EIF3a transcribed circRNAs, are associated with both drug sensitivity and translation regulation. These findings mean that they may have a functional synergy effect with EIF3a or be valuable therapeutic targets for treatment like EIF3a. This is the first study that exploits circRNAs screening from EIF3a in lung cancer, our findings provide a novel perspective on the function of EIF3a and circEIF3as in lung cancer.https://doi.org/10.1002/cam4.2338bioinformaticscircular RNAEIF3alung cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ma‐Sha Huang Fu‐Qiang Yuan Yang Gao Jun‐Yan Liu Yi‐Xin Chen Chen‐Jing Wang Bai‐Mei He Hong‐Hao Zhou Zhao‐Qian Liu |
spellingShingle |
Ma‐Sha Huang Fu‐Qiang Yuan Yang Gao Jun‐Yan Liu Yi‐Xin Chen Chen‐Jing Wang Bai‐Mei He Hong‐Hao Zhou Zhao‐Qian Liu Circular RNA screening from EIF3a in lung cancer Cancer Medicine bioinformatics circular RNA EIF3a lung cancer |
author_facet |
Ma‐Sha Huang Fu‐Qiang Yuan Yang Gao Jun‐Yan Liu Yi‐Xin Chen Chen‐Jing Wang Bai‐Mei He Hong‐Hao Zhou Zhao‐Qian Liu |
author_sort |
Ma‐Sha Huang |
title |
Circular RNA screening from EIF3a in lung cancer |
title_short |
Circular RNA screening from EIF3a in lung cancer |
title_full |
Circular RNA screening from EIF3a in lung cancer |
title_fullStr |
Circular RNA screening from EIF3a in lung cancer |
title_full_unstemmed |
Circular RNA screening from EIF3a in lung cancer |
title_sort |
circular rna screening from eif3a in lung cancer |
publisher |
Wiley |
series |
Cancer Medicine |
issn |
2045-7634 |
publishDate |
2019-08-01 |
description |
Abstract Eukaryotic initiation factor 3 (EIF3) is one of the largest and most complex translation initiation factors, which consists of 13 subunits named eukaryotic translation initiation factor 3 subunit A (EIF3a) to EIF3m. EIF3a is the largest subunit of EIF3. Previous studies suggested that EIF3a is a housekeeping gene, recent results have found that EIF3a is closely related to the tumorigenesis and drug resistance. Circular RNAs (circRNAs) derived from biologically important gene can play an important role in gene regulation. However, the mechanism underlying circRNAs’ biological functions is not well understood yet. In this work, we screened 31 EIF3a‐derived circRNAs, in which two circEIF3as were identified to be correlated with cisplatin drug sensitivity in lung cancer. Two circEIF3as were found involved in RNA‐binding proteins‐mediated biological processes and may be related to translational regulation according to bioinformatics analyses. CircEIF3as, the transcriptional initiation factor EIF3a transcribed circRNAs, are associated with both drug sensitivity and translation regulation. These findings mean that they may have a functional synergy effect with EIF3a or be valuable therapeutic targets for treatment like EIF3a. This is the first study that exploits circRNAs screening from EIF3a in lung cancer, our findings provide a novel perspective on the function of EIF3a and circEIF3as in lung cancer. |
topic |
bioinformatics circular RNA EIF3a lung cancer |
url |
https://doi.org/10.1002/cam4.2338 |
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