Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells.
The accuracy of replicating the genetic code is fundamental. DNA repair mechanisms protect the fidelity of the genome ensuring a low error rate between generations. This sustains the similarity of individuals whilst providing a repertoire of variants for evolution. The mutation rate in the human gen...
Main Authors: | Foad J Rouhani, Serena Nik-Zainal, Arthur Wuster, Yilong Li, Nathalie Conte, Hiroko Koike-Yusa, Natsuhiko Kumasaka, Ludovic Vallier, Kosuke Yusa, Allan Bradley |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-04-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC4824386?pdf=render |
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