Blocking ERK1/2 signaling impairs TGF-β1 tumor promoting function but enhances its tumor suppressing role in intrahepatic cholangiocarcinoma cells

Blocking ERK1/2 signaling impairs TGF-β1 tumor promoting function but enhances its tumor suppressing role in intrahepatic cholangiocarcinoma cells

Abstract Background Transforming growth factor-β (TGF-β) plays a paradoxical role in cancer: it suppresses proliferation at early stages but promotes metastasis at late stages. This cytokine is upregulated in cholangiocarcinoma and is implicated in cholangiocarcinoma invasion and metastasis. Here we...

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Bibliographic Details
Main Authors: Phaijit Sritananuwat, Natthaporn Sueangoen, Parichut Thummarati, Kittiya Islam, Tuangporn Suthiphongchai
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Cancer Cell International
Subjects:
Cholangiocarcinoma
ERK1/2
Invasion
Slug
Smad2/3
TGF-β1
Online Access:http://link.springer.com/article/10.1186/s12935-017-0454-2

Internet

http://link.springer.com/article/10.1186/s12935-017-0454-2

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