Autoimmune Progesterone Anaphylaxis
Progesterone induced dermatitis is a rare disorder. It typically occurs in females due to an autoimmune phenomenon to endogenous progesterone production, but can also be caused by exogenous intake of a synthetic progestin. Here in, we present a case of autoimmune progesterone anaphylaxis (AIPA) obse...
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Tehran University of Medical Sciences
2007-06-01
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doaj-0edeba7b75e346dcb1dd4be7798d287d2020-11-25T04:11:59ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492007-06-0162172Autoimmune Progesterone Anaphylaxis Mohammad Hassan Bemanian0 Mohammad Gharagozlu1 Mohammad Hossein Farashahi2 Mohammad Nabavi3 Zahra Shirkhoda4 Progesterone induced dermatitis is a rare disorder. It typically occurs in females due to an autoimmune phenomenon to endogenous progesterone production, but can also be caused by exogenous intake of a synthetic progestin. Here in, we present a case of autoimmune progesterone anaphylaxis (AIPA) observed in an adolescent female. The patient is an 18-year-old Caucasian female with no significant past medical history and no prior exogenous hormone use, who presented to her primary care physician complaining of cyclic skin eruptions with dyspnea, cough and respiratory distress. She noted that her symptoms occurred monthly, just prior to her menses. An intradermal skin test using 0.1 cml of progesterone was performed. The patient developed a 15mm wheal after 15 minutes, confirming the diagnosis of AIPA. The patient was started on a continuous regimen of an oral conjugated estrogen (0.625mg). The skin eruptions and respiratory symptoms have not returned since the initiation of this therapy. Autoimmune progesterone dermatitis manifests via the occurrence of cyclic skin eruptions. Women with the disorder commonly present with dermatologic lesions in the luteal phase of the menstrual cycle, if there are any other organ involvement in addition to skin (e.g. lung, GI) the reaction should be called as autoimmune progesterone anaphylaxis. Diagnosis of AIPA is confirmed by performing a skin allergen test using progesterone.https://ijaai.tums.ac.ir/index.php/ijaai/article/view/172AnaphylaxisAutoimmune |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohammad Hassan Bemanian Mohammad Gharagozlu Mohammad Hossein Farashahi Mohammad Nabavi Zahra Shirkhoda |
spellingShingle |
Mohammad Hassan Bemanian Mohammad Gharagozlu Mohammad Hossein Farashahi Mohammad Nabavi Zahra Shirkhoda Autoimmune Progesterone Anaphylaxis Iranian Journal of Allergy, Asthma and Immunology Anaphylaxis Autoimmune |
author_facet |
Mohammad Hassan Bemanian Mohammad Gharagozlu Mohammad Hossein Farashahi Mohammad Nabavi Zahra Shirkhoda |
author_sort |
Mohammad Hassan Bemanian |
title |
Autoimmune Progesterone Anaphylaxis |
title_short |
Autoimmune Progesterone Anaphylaxis |
title_full |
Autoimmune Progesterone Anaphylaxis |
title_fullStr |
Autoimmune Progesterone Anaphylaxis |
title_full_unstemmed |
Autoimmune Progesterone Anaphylaxis |
title_sort |
autoimmune progesterone anaphylaxis |
publisher |
Tehran University of Medical Sciences |
series |
Iranian Journal of Allergy, Asthma and Immunology |
issn |
1735-1502 1735-5249 |
publishDate |
2007-06-01 |
description |
Progesterone induced dermatitis is a rare disorder. It typically occurs in females due to an
autoimmune phenomenon to endogenous progesterone production, but can also be caused by
exogenous intake of a synthetic progestin. Here in, we present a case of autoimmune progesterone anaphylaxis (AIPA) observed in an adolescent female.
The patient is an 18-year-old Caucasian female with no significant past medical history and no
prior exogenous hormone use, who presented to her primary care physician complaining of cyclic skin eruptions with dyspnea, cough and respiratory distress. She noted that her symptoms occurred monthly, just prior to her menses. An intradermal skin test using 0.1 cml of progesterone was performed. The patient developed a 15mm wheal after 15 minutes, confirming the diagnosis of AIPA.
The patient was started on a continuous regimen of an oral conjugated estrogen (0.625mg). The skin eruptions and respiratory symptoms have not returned since the initiation of this therapy.
Autoimmune progesterone dermatitis manifests via the occurrence of cyclic skin eruptions.
Women with the disorder commonly present with dermatologic lesions in the luteal phase of the
menstrual cycle, if there are any other organ involvement in addition to skin (e.g. lung, GI) the
reaction should be called as autoimmune progesterone anaphylaxis. Diagnosis of AIPA is confirmed by performing a skin allergen test using progesterone. |
topic |
Anaphylaxis Autoimmune |
url |
https://ijaai.tums.ac.ir/index.php/ijaai/article/view/172 |
work_keys_str_mv |
AT mohammadhassanbemanian autoimmuneprogesteroneanaphylaxis AT mohammadgharagozlu autoimmuneprogesteroneanaphylaxis AT mohammadhosseinfarashahi autoimmuneprogesteroneanaphylaxis AT mohammadnabavi autoimmuneprogesteroneanaphylaxis AT zahrashirkhoda autoimmuneprogesteroneanaphylaxis |
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